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Antiretroviral treatment of US children with perinatally acquired HIV infection: temporal changes in therapy between 1991 and 2009 and predictors of immunologic and virologic outcomes


, : Antiretroviral treatment of US children with perinatally acquired HIV infection: temporal changes in therapy between 1991 and 2009 and predictors of immunologic and virologic outcomes. Journal of Acquired Immune Deficiency Syndromes 57(2): 165-173

Advances in therapy have allowed children with perinatal HIV infection in the United States to survive into adolescence. We sought to describe the disease status of a large cohort of such children and identify predictors of their current CD4 count and HIV viral load (VL). The Pediatric HIV/AIDS Cohort Study AMP Protocol is an ongoing prospective study conducted at 15 sites in the United States. Between 2007 and 2009, we enrolled a population-based sample of 451 children with perinatal HIV who were 7-16 years of age at entry. The median age of subjects at entry was 12.2 years, 53% were female, 70% were African-American, and 24% Hispanic. Their median entry CD4% was 33%, and 78% had a CD4% ≥25%; 68% had a suppressed VL. The more recent birth cohorts (1994-2002) had a significantly higher CD4% over time than the earliest birth cohort (1991-1993). The significant independent predictors of a higher CD4% at entry were a suppressed entry VL, a higher nadir CD4%, and starting antiretroviral therapy at a younger age. The mean CD4% at entry for children with a nadir CD4% ≥25% was 9.5% higher than for those with a nadir CD4% <15% (P < 0.001). Independent predictors of a suppressed entry VL were membership in a recent birth cohort, male gender, highly active combination antiretroviral therapy use at entry, and fewer prior antiretroviral therapy regimens. Most children with perinatal HIV maintain virologic suppression and good CD4 values. Earlier treatment results in better immune outcome.

US$19.90

PMID: 21407086

DOI: 10.1097/QAI.0b013e318215c7b1


Other references

Hornberg, C.; Maciuleviciute, L.; Seemayer, N.H.; Kainka, E., 1998: Induction of sister chromatid exchanges in human tracheal epithelial cells by the fractions PM-10 and PM-25 of airborne particulates. Recent epidemiological studies in the United States and in Europe indicate, that the coarse fraction (PM-10) of airborne particulates, smaller than 10 mum and particularly the fine fraction (PM-2.5) smaller than 2.5 mum are responsible for adverse...

Thunert A., 1975: Drinking water supply under specific pathogen free animal care conditions part 1 methods of improving drinking water hygiene part 2 the suitability of various filter systems for water purification personal studies and observations. Zeitschrift fuer Versuchstierkunde 17(1): 41-49

Michelucci, R.; Gardella, E.; de Haan, G-Jan.; Bisulli, F.; Zaniboni, A.; Cantalupo, G.; Alberto Tassinari, C.; Tinuper, P.; Nobile, C.; Nichelli, P.; Kasteleijn-Nolst Trenité, Dée.G.A., 2004: Telephone-induced seizures: a new type of reflex epilepsy. To report a new form of reflex epilepsy in which the seizures are repeatedly and exclusively triggered by answering the telephone. Three patients with a history of telephone-induced seizures were studied in detail by means of clinical, EEG, and ne...

Kaderávek, F.; Mikolásek, A., 1967: Effect of fanning on the course of thermoregulatory processes in the hot environment of a sauna bath. Fysiatricky A Reumatologicky Vestnik 45(3): 158-164

Navarro, M.Eugênia.Lopes.; Santos, K.Carolo.Dos.; Nascimento, Aé.Ferreira.do.; Francisqueti, F.Valentini.; Minatel, I.Otávio.; Pierine, D.Tortolero.; Luvizotto, R.Azevedo.de.Melo.; Ferreira, A.Lúcia.A.; Campos, D.Henrique.Salomé.de.; Corrêa, C.Renata., 2016: Renal inflammatory and oxidative and metabolic changes after 6 weeks of cafeteria diet in rats. Obesity is a disease in which inflammation is directly involved and can lead to impaired renal function. To evaluate the influence of short term exposure to cafeteria diet on kidney tissue inflammation and advanced glycation end products (AGEs) in...

Forschner, E.W.lf, H., 1981: Environmental contaminants in meat and meat products--a discontinued inspection estimate as a measure for consumer risk and the environmental situation. Archiv fur Lebensmittel Hygiene 32(4): 97-103

Chopra, S.; Dora, T.; Engineer, R.; Mechanery, S.; Agarwal, P.; Kannan, S.; Ghadi, Y.; Swamidas, J.; Mahantshetty, U.; Shrivastava, S.Kishore., 2016: Late rectal toxicity after image-based high-dose-rate interstitial brachytherapy for postoperative recurrent and/or residual cervical cancers: EQD2 predictors for Grade ≥II toxicity. To investigate the correlation of rectal dose volume metrics with late rectal toxicity after high-dose-rate pelvic interstitial brachytherapy. From October 2009 to November 2012, 50 patients with residual or recurrent cervical cancer were included...

ANASASHVILI.A.Ts., 1957: Surgical treatment of pulmonary tuberculosis in a tuberculosis dispensary. Problemy Tuberkuleza 35(6): 30-32

Grachan, M.L.; Tudge, M.T.; Jacobsen, E.N., 2008: Enantioselective catalytic carbonyl-ene cyclization reactions. Angewandte Chemie 47(8): 1469-1472

Singh, J., 1979: Freezing of protoplasts isolated from cold-hardened and non-hardened winter rye. Freezing tolerances of isolated protoplasts and intact tissues were similar. Sucrose enhanced freezing resistance, whereas mannitol reduced it.