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Antisnake Venom Activity of Hibiscus aethiopicus L. against Echis ocellatus and Naja n. nigricollis


, : Antisnake Venom Activity of Hibiscus aethiopicus L. against Echis ocellatus and Naja n. nigricollis. Journal of Toxicology 2010: 837864-837864

The objective of the study is to investigate whether the Hibiscus aethiopicus L. plant has neutralization activity against venoms of two clinically important snakes. The H. aethiopicus was dried and extracted with water. Different assays were performed to evaluate the plant's acute toxicity and its anti-snake venom activities. The results showed that H. aethiopicus extract alone had no effect on the viability of C(2)C(12) muscle cells, but significantly (P < .05) protected muscle cells against the toxic effects of E. ocellatus venom at 55, 150, and 300 mug/mL. The maximum protective effect of the extract was exhibited at 75 mug/mL. The extract significantly (P < .001) inhibited the cytotoxic effects of E. ocellatus venom at 300 mug/mL. All rabbits (n = 10) and guinea pigs (n = 10) were alive after the two weeks of given the lethal dosage 16 g/Kg of the H. aethiopicus extract herbal solution. No abnormal behaviour was observed of both groups of animals. All guinea pigs (n = 3) treated with venoms alone (5 mg/kg) died. However, all guinea pigs (n = 21) treated with venom (5 mg/kg) and the extract (400 to 1000 mg/kg) survived. Guinea pigs (n = 3) treated with Naja n. nigricollis venom alone (2.5 mg/kg) and guinea pigs (n = 21) venom with the extract (400 to 1000 mg/kg) died. The H. aethiopicus completely (100%) blocked the haemorrhagic activity of E. ocellatus in the egg embryo at 3.3 mg/mL of extract. These findings suggest that H. aethiopicus may contain an endogenous inhibitor of venom-induced haemorrhage.

US$19.90

PMID: 20628507

DOI: 10.1155/2010/837864


Other references

Griffith K.D.; Read E.J.; Carrasquillo J.A.; Carter C.S.; Yang J.C.; Fisher B.; Aebersold P.; Packard B.S.; Y.M.Y.; Rosenberg S.A., 1989: In vivo distribution of adoptively transferred indium 111 labeled tumor infiltrating lymphocytes and peripheral blood lymphocytes in patients with metastatic melanoma. Patients with metastatic melanoma undergoing therapy with cyclophosphamide (CPM), tumor-infiltrating lymphocytes (TIL), and interleukin-2 (IL-2) were studied for the ability of their 111In-labeled TIL or peripheral blood lymphocytes (PBL) to local...

Rodríguez-Morales, E.L.; Correa-Rivas, Mía.S.; Colón-Castillo, L.E., 2002: Monocephalus diprosopus, a rare form of conjoined twins, and associated congenital anomalies. Craniofacial duplication (diprosopus) is a rare form of conjoined twins. A case of monocephalus diprosopus with anencephaly, cervicothoracolumbar rachischisis, and duplication of the respiratory tract and upper gastrointestinal tract is reported....

Kunz, W., 1977: Effect of Solanum malacoxylon (Sendtner) on serum calcium, phosphorus and magnesium in cattle after parenteral and oral administration. Aqueous extracts prepared from 10 to 50 g dried ground leaves of the shrub, responsible for calcinosis in South American cattle, were given to 4 nonpregnant cows fed on hay and concentrate twice daily, by vein in 6 trials and by mouth in 2, as a s...

Hallek M.; Druker B.; Lepisto E.M.; Ernst T.J.; Okuda K.; Griffin J.D., 1992: Steel factor c kit ligand and gm csf use both unique and common signal transduction pathways. Journal of Cellular Biochemistry Supplement (16 PART B): 195

Desideri I.M., 1988: Abdominal complications from biliary surgery. The results and experience gained in 25 years in the management of abdominal complications from surgical procedures due to biliary tract disorders are described. Considerations are made on etiology, pathophysiology, clinical features and treatment...

Nooteboom H.P., 1985: Notes on magnoliaceae with a revision of pachylarnax and elmerrillia and the malesian species of manglietia and michelia. After the general chapters, mainly based on literature and dealing with wood anatomy, characters of the leaf epidermis and foliar sclereids, embryology and chromosome numbers, phytochemistry, and characters of the fruit, the generic delimitation o...

Susaki, J.; Hara, K.; Kajiwara, K.; Honda, Y., 2004: Robust estimation of BRDF model parameters. The effect of the Bidirectional Reflectance Distribution Function (BRDF) is one of the most important factors in correcting the reflectance obtained from remotely sensed data. Estimation of BRDF model parameters can be deteriorated by various fact...

Behn Mark D.; Linn Jian; Zuber Maria T., 2004: Effects of hydrothermal cooling and magma injection on mid-ocean ridge temperature structure, deformation, and axial morphology. Geophysical Monograph: Pages 151-165. 2004.

Wakao, S.; Andre, C.; Benning, C., 2007: Functional analyses of cytosolic glucose-6-phosphate dehydrogenases and their contribution to seed oil accumulation in Arabidopsis. Glucose-6-phosphate dehydrogenase (G6PDH) has been implicated in the supply of reduced nicotine amide cofactors for biochemical reactions and in modulating the redox state of cells. In plants, identification of its role is complicated due to the p...

Anonymous, 1973: Lean diets and atherosclerosis. West Virginia Medical Journal 69(7): 183-183