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Assessment of ADVIA Centaur analyzer for the measurement of 25-OH vitamin D


, : Assessment of ADVIA Centaur analyzer for the measurement of 25-OH vitamin D. Clinical Laboratory 58(9-10): 987-995

The aim of the present study was to evaluate some analytical performances of the ADVIA Centaur analyzer for the quantitative measurement of 25-OH Vitamin D [25(OH)D] in serum. Serum concentrations of 25(OH)D were determined by a new automated chemiluminescence immunoassay method introduced by Siemens and adapted to an ADVIA Centaur analyzer, and compared with HPLC and a commercial chemiluminescence immunoassay (Liaison DiaSorin). The assay displayed a low intra-day (CV < 7.0%) and a low inter-day imprecision (CV < 9.0%). The ADVIA Centaur demonstrated a stronger Spearman's correlation (r = 0.921), better agreement (bias = -0.3 ng/mL), and better concordance correlation coefficient of Lin (P(c) = 0.88) and better kappa index (k = 0.92) with HPLC, than the Liaison DiaSorin assay (r = 0.907, bias = 5.9 ng/mL, p(c) = 0.84, k = 0.60) with HPLC. On the other hand, a significant inverse relationship was observed between parathyroid hormone (PTH) and 25(OH)D concentrations. The ADVIA Centaur method is reliable for routine 25(OH)D determination in clinical laboratories

US$29.90

PMID: 23163115


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