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Assessment of atherosclerosis in oncologic patients using ¹⁸F-fluoride PET/CT

, : Assessment of atherosclerosis in oncologic patients using ¹⁸F-fluoride PET/CT. Annals of Nuclear Medicine 27(5): 481-486

The purpose of this study was to evaluate the prevalence, distribution, and relationship of 18F-fluoride uptake and arterial calcification in oncologic patients using 18F-fluoride PET/CT.Image data obtained from 29 oncologic patients undergoing whole-body 18F-fluoride PET/CT were evaluated retrospectively. Arterial wall 18F-fluoride uptake and calcification were analyzed both quantitatively and semiquantitatively in 8 patients with arterial 18F-fluoride uptake.Arterial 18F-fluoride uptake was observed at 35 lesions in 8 (28 %) of the 29 patients, and calcification was observed at 345 lesions in the same patients. Five of the 8 patients had prostate cancer, and the remaining patients had hepatocellular carcinoma or malignant melanoma. In these 8 patients, the prevalence of both 18F-fluoride uptake and calcification was highest in the abdominal aorta, followed by the descending thoracic aorta and the aortic arch. Colocalization of radiotracer accumulation and calcification could be observed in the 32 lesions (91 %) with arterial 18F-fluoride uptake, and only the 3 lesions (9 %) with arterial 18F-fluoride uptake were not colocalized with arterial calcification. The presence of both arterial radiotracer uptake and calcification was significantly associated with advancing age (P < 0.01).Our results suggest that 18F-fluoride PET/CT might be a useful modality for detecting active mineral deposition sites of atherosclerosis in oncologic patients.


PMID: 23443956

DOI: 10.1007/s12149-013-0706-8

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