geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Association between the circulating total osteocalcin level and the development of cardiovascular disease in middle-aged men: a mean 8.7-year longitudinal follow-up study


, : Association between the circulating total osteocalcin level and the development of cardiovascular disease in middle-aged men: a mean 8.7-year longitudinal follow-up study. Journal of Atherosclerosis and Thrombosis 22(2): 136-143

Recent studies have suggested that the serum osteocalcin level is associated with various cardiovascular risk factors. The aim of this study was to determine whether the serum total osteocalcin level is associated with the development of cardiovascular disease (CVD). A total of 1,290 men 40-78 years of age were enrolled. The subjects were followed regularly at the Health Promotion Center on an outpatient basis and during hospitalization for a mean of 8.7 years, and the incidence of CVD (coronary heart disease [CHD] and stroke) was determined. At baseline, the body mass index, body fat percentage, fasting glucose, homeostasis model assessment-insulin resistance, triglyceride and non-high density lipoprotein (HDL) cholesterol levels were inversely and the HDL cholesterol levels were positively associated with the serum osteocalcin levels. In addition, the prevalence of diabetes or metabolic syndrome decreased as the osteocalcin tertile increased. However, no differences were observed in the prevalence of hypertension across the osteocalcin tertiles. Incident CVD occurred in 74 (5.7%) of the study subjects (29 patients with CHD and 47 patients with stroke). According to the Cox proportional hazards models, however, there were no statistical differences in the development of stroke, CHD or CVD across the osteocalcin tertiles after adjusting for other risk factors for CVD, including age, body mass index, current smoking, low-density lipoprotein cholesterol, diabetes, hypertension and the serum creatinine level. In conclusion, the serum total osteocalcin level was not associated with the development of CVD after adjusting for other risk factors for CVD in this cohort.

US$19.90

PMID: 25195811

DOI: 10.5551/jat.25718


Other references

Krohn, T.C.; Hansen, A.K.rnerup, 2002: The application of traditional behavioural and physiological methods for monitoring of the welfare impact of different flooring conditions in rodents. In this study, observations on traditional methods, such as open field test, corticosterone assays and monitoring of barbiturate sleeping time, were performed to validate the impact of housing conditions on the welfare of rats and mice in order to...

Henne, A., 1973: Forest survey as means of management planning and control. Mitteilungen 11

Maxwell, P.H.; Coombes, C.; Kenny, A.E.; Lawler, J.F.; Boeke, J.D.; Curcio, M.Joan., 2004: Ty1 mobilizes subtelomeric Y' elements in telomerase-negative Saccharomyces cerevisiae survivors. When telomerase is inactivated in Saccharomyces cerevisiae, telomeric DNA shortens with every cell division, and cells stop dividing after apprx100 generations. Survivors that form in these senescent populations and resume growing have variably am...

Wilson, P., 1958: Therapeutic applications of hypothermia. Australian and New Zealand Journal of Surgery 27(3): 229-236

Brooks, R., 2002: National Safety Month in focus. The final spotlight in this annual four-week observance shines on workplace safety. Occupational Health & Safety 71(6): 26-26

Cañas, F.; Alptekin, K.; Azorin, J.Michel.; Dubois, V.; Emsley, R.; García, A.G.; Gorwood, P.; Haddad, P.M.; Naber, D.; Olivares, Jé.M.; Papageorgiou, G.; Roca, M., 2013: Improving treatment adherence in your patients with schizophrenia: the STAY initiative. Partial and non-adherence to medication is a common problem in schizophrenia, leading to an increased risk of relapse, increased likelihood of hospitalization and poorer long-term outcomes. In contrast, continuous medication in the treatment of sc...

Eadie, J.M.; Shand, W.J., 1981: The effect of Synperonic NP9 upon ciliate-free and faunated sheep. Nonyl phenol ethoxylate (Synperonic NP9) was administered to 2 ciliate-free sheep, 2 in which only Entodinium spp. were present and 2 in which a mixed Type A or Type B population was established. Many ciliates were killed, but 2 h after treatment...

Fischer, J.; Wegener, M., 2012: Ultrafast polymerization inhibition by stimulated emission depletion for three-dimensional nanolithography. To identify the depletion mechanism in the stimulated-emission-depletion (STED) inspired photoresist composed of a ketocoumarin photoinitiator in pentaerythritol tetraacrylate, we perform lithography with pulsed excitation and tunable delayed depl...

Titova N.N., 1973: Moderate mutants of amoeboaphelidium protococcarum an intra cellular parasite of protococcal algae. Soviet Genetics English Translation Of Genetika: 1975

Gredilla, R.; Lopez Torres, M.; Portero Otin, M.; Pamplona, R.; Barja, G., 2001: Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle. While the biochemical literature on free radical metabolism is extensive, there is little information on the endocrine control of tissue oxidative stress, and in the case of thyroid hormones it is mainly limited to liver tissue and to short-term e...