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Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study

, : Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. Plos One 8(11): E79803-E79803

This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years. A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status. We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)). The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'.


PMID: 24236160

DOI: 10.1371/journal.pone.0079803

Other references

Klobucar, A.; Merdić, E.; Benić, N.; Baklaić, Z.; Krcmar, S., 2006: First record of Aedes albopictus in Croatia. The first record of Aedes albopictus in Croatia was made in Zagreb, Croatia, on October 28, 2004. A total of 13 larvae were collected in a discarded ceramic toilet bowl in a forested area in the Southwest suburbs. Because the winter temperatures i...

Guarino, S., 1950: Action of local anesthetics on the effect of potassium on the sartorius muscle of the toad. Rendiconti - Istituto Superiore di Sanita 13(4): 345-348

Anonymous, 2001: Evaluation of certain veterinary drug residues in food. This report presents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs and to recommend maximum levels for such residues. The first part of the report considers an approach...

Thiebelmont Denis; Delor Claude; Cocherie Alain; Lafon Jean Michael; Goujou Jean Christian; Balde Alhassane; Bah Mamadou; Sane Hadi; Fanning C.M.rk, 2000: Un socle granito-gneissique a 3,5 Ma en Guinee, preuve supplementaire d'accretion dans le Craton ouest africain au debut de l'Archeen--A 3.5 Ga granite-gneiss basement in Guinea; further evidence for early Archean accretion within the West African Craton. Principaux Resultats Scientifiques - Bureau de Recherches Geologiques et Minieres 1999/2000: 16-17

Mushegian, A.A.; Walser, J-Claude.; Sullam, K.E.; Ebert, D., 2017: The microbiota of diapause: How host-microbe associations are formed after dormancy in an aquatic crustacean. A critical question in symbiosis research is where and how organisms obtain beneficial microbial symbionts in different ecological contexts. Microbiota of juveniles are often derived directly from their mother or from the immediate environment. Th...

K.W.; Zelano J.A.; Lazzaro R.; Lazenby W.D.; Isom O.W.; Krieger K.H., 1991: Compositional analysis of the university of wisconsin solution uw for heart preservation. Circulation 84(4 SUPPL): II491

Anonymous, 1995: Continuous Renal Replacement Therapies, International Conference. San Diego, California, November 8-10, 1995. Abstracts. Blood Purification 13(6): 385-402

Heintz Natascha, 1968: The pteraspid Lyktaspis n. g. from the Devonian of Vestspitsbergen. Systematic description, Wood Bay formation, guide fossil.

Vyrenkova, T.E., 1988: Current problems of phthisio-ophthalmology. Problemy Tuberkuleza: 11-13

Karol, M.D.; Veng-Pedersen, P.; Brashear, R.E., 1983: Diffusion and flow transfer of theophylline across the blood-brain barrier: pharmacokinetic analysis. Two possible schemes describing the transfer of theophylline across the blood-brain barrier are investigated. The first, the "diffusion only model," assumes that the rate of transfer is proportional to the difference in free drug concent...