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Association of serum bilirubin with contrast-induced nephropathy and future cardiovascular events in patients undergoing coronary intervention

, : Association of serum bilirubin with contrast-induced nephropathy and future cardiovascular events in patients undergoing coronary intervention. Plos One 7(8): E42594-E42594

Enhanced reactive oxygen species formation within the kidney following the administration of contrast media may play a key role in the development of contrast-induced nephropathy (CIN). Bilirubin has emerged as an important endogenous antioxidant molecule. This study was undertaken to determine whether bilirubin is associated with CIN and future cardiovascular events in patients undergoing coronary intervention. Totally, 544 consecutive patients received coronary intervention were enrolled. All patients were followed up for at least 3 years or until the occurrence of a major event. The primary endpoint was CIN, defined as a rise in serum creatinine (SCr) of 0.5 mg/dl or a 25% increase from the baseline value within 48 hours after the procedure. The secondary endpoint was the combined occurrence of major adverse cardiovascular events (MACE), including death, nonfatal myocardial infarction, and ischemic stroke. Overall, CIN occurred in 85 (15.6%) patients. All patients were stratified into 3 groups (low/normal/high) according to the serum bilirubin levels. In a multivariate logistic analysis, the odds ratio for CIN with low-bilirubin levels relative to high-bilirubin levels was 11.82 (95% CI, 3.25-43.03). By Cox regression analysis, serum bilirubin levels was an independent predictor of MACE in patients undergoing coronary intervention (low vs. high hazard ratio 2.26; 95% CI, 1.05-4.90). CIN is a serious complication of coronary intervention. Higher serum bilirubin concentrations were associated with lower risk of CIN and fewer cardiovascular events. The development of interventions that promote bilirubin levels may be a potential target to reduce CIN and future MACE in patients undergoing coronary intervention.


PMID: 22880046

DOI: 10.1371/journal.pone.0042594

Other references

Zhu, H.; Yao, W-zhen.; Shen, N.; Zhang, L-qiang.; Wang, X-hong.; Liang, Y-jing.; Zhou, Q-tao., 2007: Epidemiological survey of asthma in a rural area of Yanqing County in Beijing. To evaluate the epidemiology and risk factors of asthma of people aged more than 40 years living in the rural area of Beijing. The data of 1,638 people aged more than 40 years living in 5 villages of Yanqing County in Beijing were collected. Respi...

Irvin, J.L.; Irvin, E.M., 2012: Acid-base reactions of quinoline and acridine derivatives. Federation Proceedings 5(1 Pt 2): 139-139

Petravic, M.; Peter, R.; Kavre, I.; Li, L.Hua.; Chen, Y.; Fan, L-Jen.; Yang, Y-Wen., 2010: Decoration of nitrogen vacancies by oxygen atoms in boron nitride nanotubes. Decoration of nitrogen vacancies by oxygen atoms has been studied by near-edge X-ray absorption fine structure (NEXAFS) around B K-edge in several boron nitride (BN) structures, including bamboo-like and multi-walled BN nanotubes. Breaking of B-N...

Galarowski Tadeusz, 1976: New observations of the present-day suffosion (piping) processes in the Bereznica catchment basin in the Bieszczady Mts. Studia Geomorphologica Carpatho Balcanica: ages 115-124. 1976.

Anonymous, 2013: A closer look at the species behind abundancea occupancy relationships. Guedo & Lamb, in this issue of the Journal of Vegetation Science, used a 35-yr data series from two prairie communities to show that abundance occupancy relationships change over time. Scrutinizing the details behind this finding, they show that s...

Basili, S.; Ferroni, P.; Martini, F.; Paoletti, V.; D.M.tteis, A.; D.F.anco, M.; Paradiso, M.; Gazzaniga, P.P.; Musca, A.; Mammarella, A., 2000: Soluble P-selectin levels in myotonic dystrophy. Haemostasis 30(Suppl 1): 195, May

Harskuti, L.; Gelei, I.; Horn, P.; Kovach, G., 1988: Magnitude of effects and interactions influencing the slaughter value of pigs. Data on the carcass composition of 1728 crossbred barrows and gilts of Hampshire, Swedish Landrace, Belgian Landrace and synthetic origin were analysed. Overall, pigs with Hampshire inheritance had the best performance, and gilts performed better...

Andres, K.L.; Renn, T.A.; Gray, D.A.; Englund, J.M.; Olsen, G.W.; Letourneau, B.K., 2014: Evaluation of a cardiovascular Risk Reduction Program at a workplace medical clinic. The Cardiovascular Risk Reduction Program (CVRRP) was implemented in the 3M Medical Clinic in December 2009. The goal of the CVRRP was to evaluate 3M employees at risk for developing cardiovascular disease (CVD) and address any related modifiable...

Pribbenow, S.; East, M.L.; Ganswindt, A.; Tordiffe, A.S.W.; Hofer, H.; Dehnhard, M., 2016: Correction: Measuring Faecal Epi-Androsterone as an Indicator of Gonadal Activity in Spotted Hyenas (Crocuta crocuta). NlmCategory="UNASSIGNED">[This corrects the article DOI: 10.1371/journal.pone.0128706.].

Adolf, B.; Habermeyer, J.; Zinkernagel, V., 1996: Epidemiology of wheat fusarioses during the vegetation period. Laux, W [Editor] [Communications from the Federal Biological Institute for Agriculture and Forestry Berlin-Dahlem] Mitteilungen aus der Biologischen Bundesanstalt fuer Land- und Forstwirtschaft Berlin-Dahlem : 201