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Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A


, : Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A. Journal of Cell Biology 202(4): 605-621

Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation at the central spindle. KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1. In the presence of phosphorylated KIF4A, microtubules grew more slowly and showed long pauses in growth, resulting in the generation of shorter PRC1-stabilized microtubule overlaps in vitro. Cells expressing only mutant forms of KIF4A lacking the Aurora B phosphorylation site overextended the anaphase central spindle, demonstrating that this regulation is crucial for microtubule length control in vivo. Aurora B therefore ensures that suppression of microtubule dynamic instability by KIF4A is restricted to a specific subset of microtubules and thereby contributes to central spindle size control in anaphase.

US$19.90

PMID: 23940115

DOI: 10.1083/jcb.201301094


Other references

Mitchell, C., 2003: A GP's duty. Australian Family Physician 32(4): 201; Author Reply 201-201; Author Reply 201

Sunshine, P., 1972: What pediatricians should know about malabsorption, but are afraid to ask. Current Problems in Pediatrics 2(8): 3-46

Danilenko I.A.; Turkevich E.P.; Berus M.V.; Malevana L.I., 1973: Metabolism of nitrogen in the rumen and blood of cattle fed full ration feed mixes. Doklady Vsesoyuznoi Ordena Lenina i Ordena Trudovogo Krasnogo Znameni Akademii Sel'skokhozyaistvennykh Nauk Imeni V I Lenina (9): 19-21

Perry, G., 1999: Construction of high technology healthcare buildings NHS--UK. Health Estate 52(10): 26-7, 29-31

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Soliman K.F.A.; Walker C.A., 1977: Dexamethasone suppression of ovulation in pregnant mares serum treated immature rats. Experientia (Basel) 33(3): 400-401

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