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Automatic global and regional phase analysis from gated myocardial perfusion SPECT imaging: application to the characterization of ventricular contraction in patients with left bundle branch block


, : Automatic global and regional phase analysis from gated myocardial perfusion SPECT imaging: application to the characterization of ventricular contraction in patients with left bundle branch block. Journal of Nuclear Medicine 49(11): 1790-1797

Although many patients with heart failure benefit from cardiac resynchronization therapy (CRT), predicting which patients will respond to CRT remains challenging. Recent evidence suggests that the analysis of mechanical dyssynchrony using gated myocardial perfusion SPECT (MPS) may be an effective tool. The aim of this study was to evaluate global and regional gated MPS dyssynchrony measurements by comparing parameters obtained from patients with a low likelihood (LLk) of conduction abnormalities and coronary artery disease and patients with left bundle branch block (LBBB). A total of 86 consecutive patients with LLk and 72 consecutive patients with LBBB, all without prior myocardial infarction or sternotomy, were studied using gated MPS. Global (histogram SD [sigma], bandwidth [beta], and entropy [epsilon]) and regional (wall- and segment-based differences of means [Deltamicro(W) and Deltamicro(S), respectively] or modes [DeltaM(W) and DeltaM(S), respectively]) dyssynchrony measures were calculated by Fourier harmonic phase-angle analysis of local myocardial count variations over the cardiac cycle for each patient, and then unpaired t tests were used to determine which parameters were sex-specific and how well they discriminated between the LLk and LBBB populations. Receiver-operating-characteristic analysis was also performed to calculate the area under the curve (AUC), sensitivity (Ss), specificity (Sp), and optimal threshold (Th). Global parameters were found to be sex-specific, whereas regional differences were sex-independent. All parameters studied showed statistically significant differences between the groups (all global, P < 0.05; all regional, P < 0.0001). Receiver-operating-characteristic analysis yielded higher AUC, Ss, and Sp for epsilon and regional parameters (epsilon: AUC = 0.95/0.96, Ss = 94%/88%, Sp = 89%/91%, and Th = 53.9%/60.6% for women/men; Deltamicro(W): AUC = 0.93, Ss = 88%, Sp = 86%, and Th = 10.5 degrees ; Deltamicro(S): AUC = 0.94, Ss = 90%, Sp = 94%, and Th = 9.2 degrees ; DeltaM(W): AUC = 0.95, Ss = 90%, Sp = 94%, and Th = 15 degrees ; and DeltaM(S): AUC = 0.95, Ss = 88%, Sp = 90%, and Th = 10.5 degrees ) than for global parameters (sigma: AUC = 0.75/0.67, Ss = 81%/66%, Sp = 63%/64%, and Th = 16.5 degrees /22.2 degrees for women/men; beta: AUC = 0.80/0.72, Ss = 71%/71%, Sp = 79%/64%, and Th = 69 degrees /81 degrees for women/men). The computed parameters all discriminate effectively between LLk and LBBB populations. Measurements that are less dependent on the shape of the phase-angle distribution histogram provided higher sensitivity and specificity for this purpose. Further study is needed to evaluate these parameters for the purpose of predicting response to CRT.

US$19.90

PMID: 18927331

DOI: 10.2967/jnumed.108.055160


Other references

Abbas, S.; Ahmed, I.; Akhtar, P., 2004: Effect of different levels of poultry droppings on growth performance of major carps. This experiment was conducted to assess the response of fertilizing fish ponds with different levels of poultry droppings on growth performance of major carps. The treated ponds were manured with poultry droppings at the rate of 0.15 (T1) and 0.20...

Li, X.; Pereira, L.; Zhang, H.; Sanguineti, C.; Ramirez, F.; Bonadio, J.; Francke, U., 1993: Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18. Fibrillin proteins are major structural components of the 10-nm microfibrils found in elastic and nonelastic connective tissues. Previous studies have mapped the human genes for two fibrillins to chromosome bands 15q21 (FBN1) and 5q23-q31 (FBN2) a...

Beukes Nicolas J.; Klein Cornelis, 1992: Models for iron-formation deposition. Pages 147-151:

He, W.; Myers, M.R.; Spada, A.P.; Hanney, B.A.; Setzer, N.; Maguire, M.; Mailliet, P.; Gontier, S.; Guegen, J.C.ristophe; Cans, P.; Orton, E.; Cheve, M.; Kubiak, G.G.; Shah, H.C.; O'brien, M.K., 2000: Synthesis of PDGF receptor tyrosine kinase inhibitors. Abstracts of Papers American Chemical Society 219(1-2): ORGN 225

Matsi, P., 1995: Percutaneous transluminal angioplasty in critical limb ischaemia. To determine the utility of percutaneous transluminal angioplasty (PTA) in the treatment of chronic critical lower-limb ischaemia, a prospective study of 103 consecutive patients (117 limbs) was performed. A total of 209 lesions were treated in th...

Inoue, M.; Matsuo, T.; Ogata, N., 1985: Possible involvement of K+-conductance in the action of gamma-aminobutyric acid in the guinea-pig hippocampus. The mechanism underlying the action of gamma-aminobutyric acid (GABA) in the hippocampus was investigated using guinea-pig brain slices. GABA either superfused or applied directly by microiontophoresis produced a biphasic response in pyramidal cel...

Sheppard, T., 1923: List of Papers bearing on Zoology of British Isles issued during 1922. British Ass Report Corresp Soc, 515-578

Jiang, S-Wen.; Xu, S.; Chen, H.; Liu, J.; Duan, P., 2017: Oncogenic Role of SET/I2PP2A for Gynecologic Cancers. SET (SE translocation, SET) is an evolutionarily conserved gene broadly expressed in various human tissues, especially in the gonadal and neural system. As a multitasking protein, SET is involved in essential cell processes such as histone modific...

Anonymous, 1977: 1977 Caddo Research Station report. 9 brief papers were presented to report recent research conducted at the Caddo Research Station, concerning groundnuts, as part of the Peanut Health Program, and soyabean cv. trials; the following are noted.

Root David H.; Drew Lawrence J., 1979: The patterns of petroleum discovery rates. Why does the amount of petroleum discovered per unit of exploratory drilling drop off so sharply after the initial phases of exploration?.