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Avoidance or exposure to foods in prevention and treatment of food allergy?

, : Avoidance or exposure to foods in prevention and treatment of food allergy?. Current Opinion in Allergy and Clinical Immunology 10(3): 258-266

To caution against premature proposals advocating change before epidemiological and clinical evidence warrants such a paradigm shift. Until 2007, all allergy societies advocated allergen avoidance for prevention and therapy in food allergy. Since then, new evidence has prompted careful re-evaluation of the literature. In primary prevention, delayed introduction of allergenic foods to prevent food allergy was removed from most recommendations. However, there is currently no evidence that allergenic foods ought to be introduced earlier than is recommended for complementary foods, at 4-6 months of age. Here we uphold the view against an emerging school of thought that early and deliberate exposure to allergenic foods may prevent or delay the onset food allergy. While notions of promoting early oral tolerance may have some merit in theory, in practice research remains inconclusive. Of recent development are treatment advances as regards established food allergy, using food allergens to induce tolerance in highly selected populations of allergic children. However, the investigators themselves strongly warn of significant risks and stress the need to optimize safety and understand longer-term implications before these trials can be applied to routine clinical practice. In this paper we endorse the current recommendation that children with confirmed food allergy should avoid foods implicated in immediate reactions. It is currently inappropriate and potentially dangerous to advocate deliberate exposure to foods involved in serious reactions against current recommendations and particularly so among food allergic children until more basic and clinical research become available.


PMID: 20431373

DOI: 10.1097/ACI.0b013e328339ab25

Other references

Groenewald, J.H.; Weber, H.W.; Van der Walt, J.J.; Greeff, M.J.; van Zyl, J.J., 1971: Successful 24-hour experimental kidney preservation. Transplantation Proceedings 3(1): 634-636

Gaskill, B.N.; Pritchett-Corning, K.R.; Gordon, C.J.; Pajor, E.A.; Lucas, J.R.; Davis, J.K.; Garner, J.P., 2014: Energy reallocation to breeding performance through improved nest building in laboratory mice. Mice are housed at temperatures (20-26 °C) that increase their basal metabolic rates and impose high energy demands to maintain core temperatures. Therefore, energy must be reallocated from other biological processes to increase heat production t...

Iglseder, B.; Moroder, T.; Staffen, W.; Ladurner, G., 2007: High prevalence and undertreatment of hypercholesterolaemia in participants in a public stroke prevention programme in austria. There is remarkable consistency in large cohort studies regarding the relationship between serum cholesterol and the incidence of coronary heart disease (CHD), and increasing interest in the relationship between serum cholesterol and stroke. The a...

Hussain, I.; Kline, J.N., 2002: CpG oligodeoxynucleotides in asthma. Asthma is a major health problem, of which the prevalence and severity are increasing, particularly in industrialized nations. One hypothesis for this is that diminished exposure to childhood infections in modern society has led to decreased Th1-t...

Zimmer, K., 1955: The treatment of soap poisoning in criminal abortion with large blood transfusions (exchange transfusions). Die Medizinische: 1179-1181

Lukas, J.; Okali, I., 1998: Bees Hymenoptera, Apoidea of the National Nature Reserve Devinska Kobyla and Sandberg southwestern Slovakia Vcely Hymenoptera, Apoidea narodnej prirodnej rezervacie Devinska Kobyla a Sandberg juhozapadne Slovensko. Zbornik Slovenskeho Narodneho Muzea Prirodne Vedy, 44: 8-34

Blanken, P.D.; Rouse, W.R., 1996: Evidence of water conservation mechanisms in several subarctic wetland species. 1. We tested the hypothesis that subarctic hygrophilous plant species show poorly developed mechanisms for water conservation by measuring the stomatal conductance, transpiration rate and xylem pressure potential of the ubiquitous subarctic wetlan...

Tálas, M.; Butel, J.S., 1974: Infectious DNA-protein complex from cells productively infected with simian adenovirus SA7. Intervirology 3(1-2): 54-62

Costa, G.; Filiti, N., 1973: The use of Alar and ethephon on Stark Delicious apples. Alar [aminozide] at 1000 or 2000 p.p.m. was applied 24 or 72 days after full bloom; and ethephon at 200 p.p.m. was applied 1 month before harvest alone or combined with each of the 1000 p.p.m. Alar treatments. Premature fruit drop was reduced by A...

Grison, C., 1961: The multiplication of viruses in their hypersensitive hosts: the case of TMV in N. glutinosa. Study of the process of formation of local lesions in N. glutinosa inoculated with TMV. The information in the 1st paper has been noticed . The 2nd paper describes experiments at the Sta. Centrale de Pathologie Vegetale, I.N.R.A., which indicated that a thermolabile toxin is present in N. glutinosa leaves infected by TMV. The work is...