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B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis


, : B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis. Journal of Immunology 181(1): 785-794

B lymphocyte autoimmunity plays a crucial role in the pathogenesis of rheumatoid arthritis. The local production of autoantibodies and the presence of ectopic lymphoid neogenesis in the rheumatoid synovium suggest that these dedicated microenvironments resembling canonical lymphoid follicles may regulate the initiation and maturation of B cell autoimmunity. In this study, we assessed experimentally the relevance of ectopic lymphoid neogenesis for B cell autoimmunity by a detailed structural, molecular, and serological analysis of seropositive and seronegative human synovitis. We demonstrate that synovial lymphoid neogenesis is a reversible process associated with inflammation which is neither restricted to nor preferentially associated with autoantibody positive rheumatic conditions. Despite the abundant expression of key chemokines and cytokines required for full differentiation toward germinal center reactions, synovial lymphoid neogenesis in rheumatoid arthritis only occasionally progresses toward fully differentiated follicles. In agreement with that observation, we could not detect Ag-driven clonal expansion and affinity maturation of B lymphocytes. Furthermore, ectopic lymphoid neogenesis is not directly associated with local production of anti-citrullinated protein Abs and rheumatoid factor in the rheumatoid joint. Therefore, we conclude that synovial lymphoid neogenesis is not a major determinant of these rheumatoid arthritis-specific autoantibody responses.

US$29.90

PMID: 18566445


Other references

Ayers, Lj, 1986: Low-cost weed control that works. New farm 8(3): 28-33

Patt, H.M.; Clark, J.W.; Vogel, H.H., 1953: Comparative protective effect of cysteine against fast neutron and gamma irradiation in mice. Cysteine pretreatment was shown to confer significant protection against the acute lethal effects of gamma (Co60) and fast neutron (fission) irradiation in mice. The protection observed with fast neutrons is, however, about half of that found with...

Pappelis, A.J.; Katsanos, R.A., 1969: Ear removal and cell death rate in Corn stalk tissue. Observations of cell death patterns in maize inbreds C103, B2, 38-11, and Os 420 showed that ear removal delayed cell death in internodes and nodes of some inbreds and led to the conclusion that reported differences in the spread of the stalk rot...

Gordon, R.L.; Shivers, C.M.; Wieland, E.A.; Kotz, S.A.; Yoder, P.J.; Devin McAuley, J., 2016: Musical rhythm discrimination explains individual differences in grammar skills in children. This study considered a relation between rhythm perception skills and individual differences in phonological awareness and grammar abilities, which are two language skills crucial for academic achievement. Twenty-five typically developing 6-year-o...

Trevan, J.W.; Boock, E.; Burn, J.H.; Gaddum, J.H., 1929: The pharmacological assay of digitalis by different methods. A weak and a strong sample of digitalis leaf were compared with the international standard powdered leaf by 3 independent groups of workers using the 3-hr., the 12-hr., and the intravenous frog methods, the cat and the guinea pig methods and the m...

Tanaka, H., 1953: Studies in the seven species of cheyletid mites of Japan. Japanese Journal of Sanitary Zoology, 4: 72-79

Kavinski, L.; Neto, J.; Bove, S., 1979: Incidence of clinic and surgery cases in veterinary hospital of University Federal of Parana--Brazil. Revista do Sector de Ciencias Agrarias 1(1): 55-62

Kvetnanský, R.; Tigranian, R.A.; Jíndra, A.; Viting, T.A., 1982: Renin-angiotensin-aldosterone system and electrolyte metabolism in the blood of rats after a flight on the Kosmos-1129 biosatellite. Kosmicheskaia Biologiia i Aviakosmicheskaia Meditsina 16(4): 85-87

Decottignies, A.; Owsianik, G.; Ghislain, M., 1999: Casein kinase I-dependent phosphorylation and stability of the yeast multidrug transporter Pdr5p. The pleiotropic drug resistance protein, Pdr5p, is an ATP-binding cassette transporter of the plasma membrane of Saccharomyces cerevisiae. Overexpression of Pdr5p results in increased cell resistance to a variety of cytotoxic compounds, a phenotyp...

Drzewiecki, Tadeusz M., 2001: Methods and apparatus for real time fluid analysis. A gas analyzer (10) integrated into the main passageway (11) of a breathing circuit includes pressure-drop flow element (12) that measures a pressure drop across an orifice, an acoustic flowmeter (14) measures the speed of sound in the gas mixture...