geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes


, : Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes. Journal of Heart and Lung Transplantation 29(5): 504-508

Balancing immunosuppression to prevent rejection while minimizing infection or drug toxicity risk is a major challenge in heart transplantation. Therapeutic drug monitoring alone is inadequate to measure the immune response. An immune monitoring (IM) assay (ImmuKnow; Cylex, Columbia, MD) performed on peripheral blood measures adenosine triphosphatase (ATP) release from activated lymphocytes and may predict the immune state. Therefore, we sought to determine the utility of IM in heart transplant recipients. Between November 2005 and July 2008, 296 heart transplant recipients had a total of 864 IM assays performed at 2 weeks to 10 years post-transplant and were correlated with infection and rejection events that occurred within 1 month after IM testing. All patients received standard triple-drug immunosuppressive therapy with tacrolimus, mycophenolate mofetil and corticosteroids, without induction therapy. There were 38 infectious episodes and 8 rejection episodes. The average IM score was significantly lower during infection than steady state (187 vs 280 ng ATP/ml, p < 0.001). The average IM score was not significantly different during rejection when compared with steady state (327 vs 280 ng ATP/ml, p = 0.35). Interestingly, 3 of 8 rejection episodes were antibody-mediated rejections and had hemodynamic compromise and, for these, the mean IM score was significantly higher than for steady-state patients (491 vs 280 ng ATP/ml, p < 0.001). The non-invasive IM test appears to predict infectious risk in heart transplant patients. The association between high IM scores and rejection risk is inconclusive due to the small number of rejection episodes. Further studies with larger sample sizes for rejection episodes are required.

US$19.90

PMID: 20133166

DOI: 10.1016/j.healun.2009.12.015


Other references

Gaballa, A.; Cao, M.; Helmann, J.D., 2003: Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon. Copper ions induce expression of the Bacillus subtilis copZA operon encoding a metallochaperone, CopZ, and a CPx-type ATPase efflux protein, CopA. The copZA promoter region contains an inverted repeat sequence similar to that recognized by the mer...

O'connor, R.J., 1953: Glycogen in the dividing of the liver of the chicken embryo. Nature 172(4380): 678-679

Yen, C-Po.; Beckman, J.M.; Vivas, A.C.; Bach, K.; Uribe, J.S., 2016: Effects of intradiscal vacuum phenomenon on surgical outcome of lateral interbody fusion for degenerative lumbar disease. OBJECTIVE The authors investigated whether the presence of intradiscal vacuum phenomenon (IVP) results in greater correction of disc height and restoration of segmental lordosis (SL). METHODS A retrospective chart review was performed on every pat...

Liu YuHuan; Yin XueYang; Lin YiDing, 1998: Factors affecting flowering efficiency of jasmine by chemical control. Results are presented of trials on the use of an unspecified fertilizer (Moliwang) for increasing jasmine flower production. In field trials, Moliwang application increased flower yield to 5877 kg/ha, which was 58.3% and 28.6% higher than the yiel...

Maslauskas, K.; Rimdeika, R.; Rapoliene, J.; Saladzinskas, Z.; Samsanavicius, D.; Kaikaris, V., 2009: The comparison of two methods of treatment evaluating complications and deficiency of functions of hands after deep partial skin thickness hand burns. Hands actively participate in daily activities of a human; therefore, hands are the most vulnerable parts of the human body. People injure hands so often because namely hands are in the closest position to the dangerous equipment. According to the...

Bénitah, J.P.; Vassort, G., 1999: Aldosterone upregulates Ca(2+) current in adult rat cardiomyocytes. Aldosterone is associated with the pathogenesis and progression of left ventricular hypertrophy and heart failure, independent of its relation with arterial blood pressure. However, little information exists about the possible influence of this mi...

Kaumann, A.; Bartel, S.; Molenaar, P.; Sanders, L.; Burrell, K.; Vetter, D.; Hempel, P.; Karczewski, P.; Krause, E.G., 1999: Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure. Background - Catecholamines hasten cardiac relaxation through beta-adrenergic receptors, presumably by phosphorylation of several proteins, but it is unknown which receptor subtypes are involved in human ventricle. We assessed the role of beta1- a...

Chouikhi, S.M.; Wilde, P.J., 1987: Use of an open-ended coaxial probe for moisture measurement. Dielectric measurements, using an RF impedance analyser, were carried out on potato powder samples with different moisture content (5-45% wet basis). Both moisture and density influenced dielectric properties (illustrated). It was concluded that t...

Arehole S.; Salvi R.J.; Saunders S.S.; Hamernik R.P., 1987: Evoked response forward masking functions in chinchillas. Evoked potentials were obtained from the inferior colliculus of awake chinchillas using a 'forward masking' stimulus paradigm. The response was elicited using a brief probe tone presente d10 dB above threshold. Forward masking functions...

Samsam, M.; Covenas, R.; Ahangari, R.; Yajeya, J.; Narvaez, J.A.; Tramu, G., 2000: Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion. The central terminals of the primary sensory trigeminal ganglion (TG) neurons projecting into the caudal trigeminal nucleus (CTN) of the rat exhibit neurokinin A (NKA)-, substance P (SP)-, and calcitonin gene-related peptide (CGRP)-immunoreactivit...