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Benhamycin, novel alkaloid from terrestrial Streptomyces sp

, : Benhamycin, novel alkaloid from terrestrial Streptomyces sp. Natural Product Research 21(13): 1205-1211

During our screening for bioactive natural compounds from microorganisms, a novel alkaloid has been isolated from a terrestrial Streptomyces sp. isolate NR12, and named as benhamycin (1). This was along with the known metabolites, uracil, thymine, p-hydroxybenzoic acid, 2'-deoxyuridin, tryptophol, indolyl-3-carboxylic acid, and indolyl-3-carbaldehyde. Chemical structure of the novel compound was determined by detailed analysis of its spectroscopic data (extensive NMR experiments, 1 & 2D, MS spectroscopy, and MS high resolution). Structurally, Benhamycin (1) is a pentacyclic aromatic compound bearing an acridine moiety lactamized with benzene. Biological studies showed that the strain extract was moderately active against Gram-positive, Gram-negative bacteria and fungi.


PMID: 17987502

DOI: 10.1080/14786410701526024

Other references

Trobisch, Dietmar., 1995: Observations on the keeping of Algyroides fitzingeri Wiegmann, 1834 Eine Beobachtungen bei der Haltung von Algyroides fitzingeri Wiegmann, 1834. Eidechse. 15 April; 614: 28-29

Anonymous, 1981: Gold contract to be traded in sterling. Six recommendations for transactions in the gold futures market which will be held in the London Metal Exchange and the prices will be quoted in pounds sterling.

Kolmer, J.A.; Liu, J.Q., 2001: Simple inheritance of partial resistance to leaf rust in two wheat cultivars. The wheat cultivars Westphal 12A and BH1146 were characterized in previous studies as having partial resistance to the leaf rust pathogen Puccinia triticina [P. recondita]. In the present study, genetic analysis showed that Westphal 12A has three...

Glassman S.F., 1971: Reevaluation of syagrus leofgreni m and syagrus rachidii m. Fieldiana Botany 34(2): 11-25

Anonymous, 2013: Stability of Alfv n eigenmodes in the vicinity of auroral arc. The purpose of this study is to give a theoretical suggestion to the essential question why east-west elongated auroral arc can keep its anisotropic structure for a long time. It could be related to the stability of east-westward traveling modes i...

Wasi, P.; Pravatmuang, P., 1973: Immunologic diagnosis of alpha-thalassemia. Journal of the Medical Association of Thailand 56(11): 654-657

Lasco, R.D.; Malinao, E.C., 1993: Height growth and herbage production of seven MPTS used as hedgerows in an alley cropping system: an on-farm experiment. Data were collected from 7 multipurpose trees (MPTS: Acacia mangium, A. auriculiformis, A. vellosa [A. villosa], Leucaena leucocephala, L. diversifolia, Flemingia congesta [F. macrophylla], and Gliricidia sepium) in an alley cropping trial in a fa...

Durfee, M.J.; Gellert, G.A.; Tilton-Durfee, D., 1992: Origins and clinical relevance of child death review teams. Interagency child death review teams have emerged in response to the increasing awareness of severe violence against children in the United States. Since 1978, when the first team originated in Los Angeles, Calif, child death review teams have bee...

Rouen, A.; Carlier, Léa.; Heide, S.; Egloff, M.; Marzin, P.; Ader, F.; Schwartz, M.; Rogers, E.; Joyé, N.; Balet, R.; Lédée, N.; Prat-Ellenberg, L.; Cassuto, N.Guy.; Siffroi, J-Pierre., 2017: Potential selection of genetically balanced spermatozoa based on the hypo-osmotic swelling test in chromosomal rearrangement carriers. Chromosomal translocations and other balanced rearrangements, although usually associated with a normal phenotype, can lead to the transmission of an abnormal unbalanced genome to the offspring. Balanced and unbalanced spermatozoa, being indisting...

Zola H.; Mantzioris B.X.; Webster J.; Kette F.E., 1989: Circulating human t and b lymphocytes express the p55 interleukin 2 receptor molecule tac cd25. Using a highly sensitive immunoflurescence procedure 15-45% of blood lymphocytes from normal human donors can be shown to react with anti-TAC (CD25) monoclonal antibodies. The standard procedure for indirect immunofluorescence doses not allow the...