+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Bilateral areolar hyperpigmentation following transdermal application of compounded hormone replacement therapy

, : Bilateral areolar hyperpigmentation following transdermal application of compounded hormone replacement therapy. International Journal of Pharmaceutical Compounding 16(2): 110-114

A 61 year-old post-menopausal Caucasian woman presented to the pharmacy to re-initiate hormone therapy after having discontinued treatment for three years. She had discontinued previous hormone therapy due to severe hyperpigmentation of both nipples and areola. She stated that her nipples and areola had turned black, as if they had been burned. This reaction seemed unique, and we felt that it warranted further investigation.


PMID: 23050322

Other references

Jayanth, S.T.; Gaikwad, P.; Promila, M.; Muthusami, J.C., 2013: The Sinus That Breeds Fungus: Subcutaneous Zygomycosis Caused by Basidiobolus ranarum at the Injection Site. Subcutaneous zygomycosis is caused by Basidiobolus ranarum which is endemic in India. We report a case of a housewife who presented with a persistent discharging sinus from the right gluteal region subsequent to an intramuscular injection which wa...

Correa,S.F.; Souza,; Pereira,T.; Alves,G.V.deL.; Oliveira,; Silva,M.G.da; Vargas,H., 2008: Determination of thermal diffusivity in papaya pulp as a function of maturation stage. In order to determine the penetration of the thermal wave in pawpaw (<i>Carica papaya</i>) cv. Golden fruit pulp, thermal diffusivity of the pulp was obtained by measuring temperature at four different depths. The measurements were con...

Ogawa, T.W.tanabe, Y.M.shi, T.O.ada, Y., 1991: Trans complementation of virus-encoded replicase components of tobacco mosaic virus. We examined whether the 130K and 180K proteins of tobacco mosaic virus (TMV), the putative virus-encoded replicase components, produced by a replication-competent TMV mutant could complement a replication-defective mutant in a single cell. The rep...

Reise, K.; Gollasch, S.; Wolff, W.J., 2002: Introduced marine species of the North Sea coasts. About 80 non-indigenous species are assumed to have been introduced into the North Sea by transoceanic shipping and aquaculture. The number is certainly underestimated as most small organisms received insufficient attention at the species level. A...

Merritt, J.E.; Taylor, C.W.; Rubin, R.P.; Putney, J.W., 1986: Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas. The initial response of many cells to 'Ca2+-mobilizing' agonists is phospholipase C-mediated hydrolysis of phosphatidylinositol bisphosphate to inositol trisphosphate (IP3) and diacylglycerol. It has been suggested, by analogy with recep...

Oliphant, M.; Berne, A.S., 1988: Aggressive neuroblastoma simulating Wilms tumor. Radiology 167(3): 878-878

Clayton, R.M.; Campbell, J.C.; Truman, D.E., 1968: A re-examination of the organ specificity of lens antigens. Experimental Eye Research 7(1): 11-29

Saidapur S.K.; Nadkarni V.B., 1972: Delta 5 3 beta hydroxy steroid dehydrogenase and glucose 6 phosphate dehydrogenase in testis of toad bufo melanostictus. Indian Journal of Experimental Biology 10(6): 425-427

Fahmy, N.M., 1979: Indications and contraindications for deliberate hypotension with a review of its cardiovascular effects. International Anesthesiology Clinics 17(1): 175-187

Alakeson, V.; Pande, N.; Ludwig, M., 2013: A plan to reduce emergency room 'boarding' of psychiatric patients. Overcrowded U.S. emergency rooms have become a place of last resort for psychiatric patients. Psychiatric boarding, defined as psychiatric patients' waiting in hallways or other emergency room areas for inpatient beds, is a serious problem na...