+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Biological variation of laboratory analytes based on the 1999-2002 National Health and Nutrition Examination Survey

, : Biological variation of laboratory analytes based on the 1999-2002 National Health and Nutrition Examination Survey. National Health Statistics Reports (): 1-7

Biological variation consists of within-person (WP) and between-person (BP) variation. These components of biological variation are used to set analytical goals for imprecision and bias, evaluate serial changes for individual analytes, and assess the clinical utility of population-based reference intervals. Estimates of WP coefficients of variation (CVw) and BP coefficients of variation (CVg) for laboratory analytes were estimated from the 1999-2002 National Health and Nutrition Examination Survey (NHANES). NHANES is a survey of the noninstitutionalized civilian U.S. population that uses a stratified, multistage probability design to collect a nationally representative sample. Between- and within-person variations were estimated for 34 laboratory analytes, including general biochemical, nutritional, and environmental analytes. Between-person variation was estimated taking into account the complex sample design of NHANES by Taylor series linearization. For WP variation, a nonrandom sample was obtained with an average of 18.8 days (range: 3-51 days) between two analyte measurements. Data outliers were excluded using Tukey's method to obtain more stable estimates of variation. The BP and WP variations were estimated on as many as 18,761 and 853 sample persons, respectively. When compared with the BP sample, the WP sample was older (mean age: 39 compared with 30 years) and had more non-Hispanic white (45% compared with 37%) and fewer Mexican-American (19% compared with 30%) persons. There was no statistically significant difference in gender proportions between the BP and WP samples. Serum sodium had the lowest CVg (1.8%) and the lowest CVw (1.0%). The index of individuality (CVw/CVg) ranged from 0.20 for blood lead to 0.76 for serum iron. The CVg exceeded the analytical method coefficient of variation for all analytes. Within-person variation was also compared between males and females, and several analytes revealed significant differences (p < 0.01). Serum ferritin had the greatest difference for CVw (males, 17.9% compared with females, 28.8%).


PMID: 20540274

Other references

Gei, N.N., 1952: Seasoning of wood with the aid of infra-red radiation.. According to results of tests, thin material (for packing, skirting, etc.) can be seasoned by this method in ca. 1/10 of the time required by conventional drying. Belt-conveyor transport during seasoning can be introduced.

Levin, F.I., 1964: Method for the quantitative determination of the organic mass of agricultural crops during the study of the biological cycle of nitrogen and mineral elements. Roots should be washed out of undisturbed right-angled monoliths whose dimensions are the same as or a multiple of the inter-row width. The monolith should be soaked in water for 6-24 hr before the roots are washed out. Washing the roots out of di...

Murakami, T.; Tsujikawa, A.; Ohta, M.; Miyamoto, K.; Kita, M.; Watanabe, D.; Takagi, H.; Yoshimura, N., 2006: Photoreceptor status after resolved macular edema in branch retinal vein occlusion treated with tissue plasminogen activator. PURPOSE: To evaluate the integrity of photoreceptors in macular edema (ME) associated with branch retinal vein occlusion after intravitreal tissue plasminogen activator.DESIGN: Retrospective, interventional case series.METHODS: Nineteen eyes with...

Lin T.H.ien; Hua; Wang Pei Ling; Lee Tung Yi; Chung Sun Lin; Lan Ching Ying, 2003: Preliminary (super 40) Ar- (super 39) Ar thermochronological study of Dien Bien Phu Fault, northern Vietnam. Eos, Transactions, American Geophysical Union 84(46, Suppl

Minson, R.B.; McRitchie, R.J.; Morris, M.J.; Chalmers, J.P., 1990: Effects of neuropeptide Y on cardiac performance and renal blood flow in conscious normotensive and renal hypertensive rabbits. The effects of neuropeptide Y (NPY, 10 micrograms/kg bolus iv) on cardiac output, renal blood flow and myocardial contractility were determined in intact renal hypertensive and normotensive rabbits instrumented with ultrasonic flow transducers or...

Zhou, Y.; Gottesman, S., 1998: Regulation of proteolysis of the stationary-phase sigma factor RpoS. RpoS, the stationary-phase sigma factor of Escherichia coli, is responsible for increased transcription of an array of genes when cells enter stationary phase and under certain stress conditions. RpoS is rapidly degraded during exponential phase a...

Cherns, Lesley, 1998: Chelodes closely related Polyplacophora (Mollusca) from the Silurian of Gotland, Sweden. Silicified assemblages of Silurian chitons (polyplacophorans) from Gotland, Sweden are dominated quantitatively by a new, Wenlock species of the long-ranging genus Chelodes; C. actinis sp. nov. is described herein. Head sclerites, previously unkno...

Soler-Humanes, Río.; Lobato-Bancalero, L.Alonso.; Sanchiz-Cárdenas, E.; Marques-Merelo, E.; Espada-Muñoz, J.Francisco.; Daza-González, J.José.; del-Fresno-Asensio, A.; Fernández-García, F.Javier.; Torres-Moreno, C.; Sánchez-Viguera, T.; Carranque-Chaves, G., 2015: Colorrectal Kaposi's sarcoma. Revista Espanola de Enfermedades Digestivas 106(3): 229-230

Chapman, J.M.; Ormerod, W.E., 1966: The survival of Toxoplasma in infected mosquitoes. An incomplete field study in Lincolnshire, England, suggested that toxoplasmosis might be transmitted from pig to man by mosquitoes. Although the results were inconclusive they suggest this experimental work recorded in this paper. Trophozoites of...

Song BaoHua; L.F.Zeng; H.X.nQiang; N.C.enKai, 2000: The determination of composition and content of amino acids in leaf protein of 30 species and its nutritive value. The composition and content of amino acids in leaf protein (LP) of 30 species with protein contents >50% are tabulated.