+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Bright light therapy in Parkinson's disease: a pilot study

, : Bright light therapy in Parkinson's disease: a pilot study. Movement Disorders 22(10): 1495-1498

Several observations suggest a beneficial effect of melatonin antagonism for Parkinson's disease (PD). Although bright light therapy (BLT) suppresses melatonin release and is an established treatment for depression and sleep disturbances, it has not been evaluated in PD. We examined effects of BLT on motor symptoms, depression, and sleep in PD in a randomized placebo-controlled double-blind study in 36 PD patients, using Parkinson's Disease Rating Scale (UPDRS) I-IV, Beck's Depression Inventory, and Epworth Sleepiness Scale. All patients received BLT for 15 days in the morning, 30 min daily. Illuminance was 7.500 lux in the active treatment group and 950 lux in the placebo group. Although group differences were small, BLT led to significant improvement of tremor, UPDRS I, II, and IV, and depression in the active treatment group but not in the placebo group. It was very well tolerated. Follow up studies in more advanced patient populations employing longer treatment durations are warranted.


PMID: 17516492

DOI: 10.1002/mds.21542

Other references

Mott, K.E., 1988: To wash or not. Nytrel filters and urinary schistosomiasis. The re-use of Nytrel filters for the diagnosis of urinary schistosomiasis is discussed. Current recommended washing procedures are outlined, and some field observations of their re-use are recorded.

Galatola, G.; Fracchia, M.; Jazrawi, R.P., 1995: Effect of colectomy with ileo-anal anastomosis on the biliary lipids. Total colectomy with ileo-anal anastomosis is an effective treatment for ulcerative colitis and familial adenomatous polyposis. The absence of the colon and the coexistence of bile acid malabsorption may increase bile lithogenicity, but data on bi...

Hung, K.K.C.; Cheung, C.S.K.; Rainer, T.H.; Graham, C.A., 2009: EMS systems in China. The prehospital emergency service is the initial part of the Emergency Medical Service System (EMSS) in China, and is the de facto overall emergency medical service for China. As the EMSS in China continues to undergo rapid development, it faces t...

Missale, C.; Memo, M.; Liberini, P.; Carruba, M.O.; Spano, P., 1985: Evidence for the presence of D1 and D2 dopamine receptors in the rat adrenal cortex. European Journal of Pharmacology 109(2): 315-316

Snider, D.P.; Underdown, B.J.; Mcdermott, M.R., 1997: Intranasal antigen targeting to MHC class II molecules primes local IgA and serum IgG antibody responses in mice. Covalent conjugates of hen egg lysozyme (HEL) and anti-major histocompatibility complex (MHC) class II monoclonal antibodies (mAb) were used to immunize mice intranasally. Three weeks after intranasal (IN) priming, mice responded rapidly to IN cha...

Yip, S.; Rottmann, J.; Berbeco, R., 2015: The impact of cine EPID image acquisition frame rate on markerless soft-tissue tracking. Although reduction of the cine electronic portal imaging device (EPID) acquisition frame rate through multiple frame averaging may reduce hardware memory burden and decrease image noise, it can hinder the continuity of soft-tissue motion leading t...

Quinlivan, M.; Cullinane, A.; Nelly, M.; Van Maanen, K.; Heldens, J.; Arkins, S., 2004: Comparison of sensitivities of virus isolation, antigen detection, and nucleic acid amplification for detection of equine influenza virus. Four seronegative foals aged 6 to 7 months were exposed to an aerosol of influenza strain A/Equi/2/Kildare/89 at 106 50% egg infective doses (EID<sub>50</sub>)/ml. Nasopharyngeal swabs were collected for 10 consecutive days after chall...

Tubino, P., 1966: The "prophylactic antibiotic" in pediatric surgery. Hospital 70(6): 1653-1657

Van Graas Ger; D.L.euw J.W.; Schenck P.A., 1980: Type and maturity of sedimentary organic matter as reflected by pyrolytic methods. Abstracts - International Palynological Conference 5: 401

Seymour, R.C.; Campbell, J.B.; Wright, R.J., 1994: Control of Western corn rootworm larvae in West Central Nebraska, 1992. Burditt, A K , Jr [Editor] Arthropod Management Tests 209