+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Burkitt Lymphoma: beyond discoveries

, : Burkitt Lymphoma: beyond discoveries. Infectious Agents and Cancer 8(1): 35-35

First described in 1958 in Uganda, Burkitt lymphoma (BL) attracted interest worldwide following reports of its uneven geographic distribution and rapidly fatal clinical course. Both suggested infectious etiology and curability. Seminal discoveries followed in quick succession. Viral etiology - due to Epstein-Barr virus (EBV) - was confirmed. Chromosomal translocations, involving cellular MYC, a protooncogene, were discovered, shown to be a hallmark of BL, and central to the genetic basis of cancer. Cure of BL using combination chemotherapy was demonstrated. Unfortunately, civil disturbance in Africa disrupted BL research and blunted its impact on education and oncology care in Africa. Important questions went unanswered. The risk of BL due to malaria or EBV was not quantified. Efforts to answer whether BL could be prevented - by preventing malaria or early EBV infection - were abandoned. The mechanism of malaria in BL is unknown. In Africa, BL remains mostly fatal and diagnosis is still made clinically. Unprecedented advances in molecular, genomics and proteomic technologies, promising to unlock mysteries of cancers, have re-awakened interest in BL. With return of stability to Africa, the unanswered questions about BL are re-attracting global interest. This interest now includes exploiting the knowledge gained about genetics, proteomics, and bioinformatics to enable the development of targeted less toxic treatment for BL; and simpler methods to diagnose BL with high accuracy and sensitivity. The articles in the Burkitt Lymphoma (BL): Beyond Discoveries in Infectious Agents and Cancer highlight BL as priority. Authors explore etiology, pathology, pathogenesis of BL, and whether knowledge gained in the studies of BL can catalyze sustainable cancer services in one of the world's poorest served regions.


PMID: 24079372

DOI: 10.1186/1750-9378-8-35

Other references

Longley, L., 2007: Safe hibernation of tortoises. Veterinary Times 37(39): 16-17

Anonymous, 2013: Does behavioral isolation prevent interspecific mating within a parallel ecotypic wolf spider radiation from the Galapagos?. Behavioral isolation may play an important role in speciation. However, the roles of divergence time and ecological specialization on the evolution of intrinsic barriers to gene flow are poorly understood. On the Gal pagos, ecotypic differentiatio...

Boileau, C.; Martel-Pelletier, J.; Fahmi, H.; Mineau, Fçois.; Boily, M.; Pelletier, J-Pierre., 2007: The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways. Emerging evidence indicates that peroxisome proliferator-activated receptor gamma (PPARgamma) may have protective effects in osteoarthritis (OA). The aim of this study was to evaluate the in vivo effect of a PPARgamma agonist, pioglitazone, on the...

Michalak-Stoma, A.; Tabarkiewicz, J.; Olender, A.; Juszkiewicz-Borowiec, M.; Stoma, F.; Pietrzak, A.; Pozarowski, P.; Bartkowiak-Emeryk, Młgorzata., 2009: The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells. Propionibacterium acnes (P. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder. It has a proinflammatory activity and takes part in immune reactions modulating the Th1/Th2 cellular response....

Manee, Abram Herbert., 1909: Some observations in Southern Pines, N. Carolina. Entomological News Philadelphia, 20 252-254

Hofer, F., 1977: Involvement of plasmids in lactose metabolism in Lactobacillus casei suggested by genetic experiments. A lactose positive (lac+) culture of L. casei 1185, maintained and propogated in MRS broth with lactose, contained approx. 1% lactose negative (lac-) cells at all times. After 40 transfers in MRS broth with glucose, 98% lac- cells were present. Tr...

Wang, S.; Han, X.; Wang, J.; Yao, J.; Shi, Y., 2015: Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenografts. Chromosome Region Maintenance 1 (CRM1) is a nuclear exporter and its inhibitor has anti-tumor activity in various cancers. This study assessed the therapeutic efficiency of the novel CRM1 inhibitor KPT-185 on non-small cell lung cancer (NSCLC). NS...

Fernicola, A.R., 1954: Idiopathic hemorrhagic infarction of the testicle in the newborn. Journal of Urology 72(2): 230-235

Thomas, L.V.; Davies, E.A.; Delves-Broughton, J.; Wimpenny, J.W., 1999: Synergist effect of sucrose fatty acid esters on nisin inhibition of gram-positive bacteria. Nisin in combination with the sucrose fatty acid esters, sucrose palmitate (P-1570 and P-1670) or sucrose stearate (S-1570 and S-1670) was tested against a range of Gram-negative and Gram-positive bacteria. Initial liquid culture investigation sho...

Palmer, T.A.; Montagna, P.A.; Kalke, R.D., 2013: The effects of opening an artificial tidal inlet on hydrography and estuarine macrofauna in Corpus Christi, Texas. Packery Channel is part of a complex of storm washover channels which, before 1912, have opened intermittently, linking the Laguna Madre and Corpus Christi Bay, Texas with the Gulf of Mexico. On 21 July 2005, with the assistance of Hurricane Emily...