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Burrowing and nest building behavior as indicators of well-being in mice


, : Burrowing and nest building behavior as indicators of well-being in mice. Journal of Neuroscience Methods 234: 139-146

The assessment of pain, distress and suffering, as well as evaluation of the efficacy of stress-reduction strategies, is crucial in animal experimentation but can be challenging in laboratory mice. Nest building and burrowing performance, observed in the home cage, have proved to be valuable and easy-to-use tools to assess brain damage or malfunction as well as neurodegenerative diseases. Both behaviors are used as parameters in models of psychiatric disorders or to monitor sickness behavior following infection. Their use has been proposed in more realistic and clinically relevant preclinical models of disease, and reduction of these behaviors seems to be especially useful as an early sign of dysfunction and to monitor disease progression. Finally, both behaviors are reduced by pain and stress. Therefore, in combination with specific disease markers, changes in nest building and burrowing performance may help provide a global picture of a mouse's state, and thus aid monitoring to ensure well-being in animal experimentation.

US$19.90

PMID: 24525328

DOI: 10.1016/j.jneumeth.2014.02.001


Other references

Throckmorton, T.W.; Hilibrand, A.S.; Mencio, G.A.; Hodge, A.; Spengler, D.M., 2003: The impact of adjacent level disc degeneration on health status outcomes following lumbar fusion. Study Design: A retrospective review of patient outcomes after lumbar spinal fusion. Objective: To determine whether patients with a fusion ending adjacent to a "degenerated disc" (DDD group) had worse clinical outcomes than patients wit...

Usman, N.; Karpeisky, A.; Beigelman, L.; Modak, A., 1997: 2-Deoxy-2-alkynucleotide containing nucleic acid. Official Gazette of the United States Patent & Trademark Office Patents 1199(3): 1899, June 17

Nudleman K.L.; Golden M.; Weller S.; Debernardi D.; Charles A., 1981: Evaluation of nerve conduction velocities in insulin dependent diabetic patients after short term glucose controlled insulin infusion. Electroencephalography & Clinical Neurophysiology 52(5): 106P

Rodriguez B.J.; Peinado L.E.; Gomez C.A.G.; Zamora L.M., 1977: Nutritive value of various shrubs. Data are presented on the chemical composition, in vivo and in vitro digestibility and ME content of the browse and fruits of several trees and shrubs, including Erica arborea, Quercus ilex, Arbutus unedo, Pistacia lentiscus, Myrtus communis and P...

Winiarska-Majczyno, M.; Morkowska, E., 1985: Maxillary orthopedic and logopedic treatment of children with cleft palate. Czasopismo Stomatologiczne 38(3): 236-243

Ohrbach R.; Gale E.N., 1989: Pressure pain thresholds and differential diagnosis of masticatory muscle disorders. Journal of Dental Research 68(SPEC ISSUE): 329

Li, T.; Peng, T., 2013: Traditional Chinese herbal medicine as a source of molecules with antiviral activity. Traditional Chinese herbal medicine (TCHM) is widely used in the prevention and treatment of viral infectious diseases. However, the operative mechanisms of TCHM remain largely obscure, mainly because of its complicated nature and the fragmented n...

Sanford I.Strausberg, 1982: Hydrogeologic control of localized iron-enriched ground water, Lima, Ohio. Entrenchment and subsequent filling of a glacial valley have led to localization of iron-enriched groundwater in the Silurian carbonate aquifer at the Vistron plant, Lima, Ohio. All production wells are open exclusively to the carbonate aquifer. W...

Ozawa, H., 2001: Fifty years history of new drugs in Japan: the developments and trends of antihypertensive drugs. The novel antihypertensive drugs which have been discovered and developed in the latter half of the 20th century were investigated. Newly discovered or improved drugs are approved by the Ministry of Health and Welfare in Japan, and after then they...

Young Seo Kim, Min Young Noh, J.Young Kim, Hyun-Jeung Yu…, 2013: Direct GSK-3? Inhibition Enhances Mesenchymal Stromal Cell Migration by Increasing Expression of Beta-PIX and CXCR4. Mesenchymal stromal cells (MSCs) are emerging as candidate cells for the treatment of neurological diseases because of their neural replacement, neuroprotective, and neurotrophic effects. However, the majority of MSCs transplanted by various route...