geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure


, : CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure. Haematologica 94(3): 423-427

Rituximab binds an epitope on the CD20 antigen, encompassed in exon 5 of the MS4A1 gene. We sequenced this region and correlated the presence of mutations with CD20 protein expression and response to R-CHOP in patients with diffuse large B-cell lymphoma: 264 diagnostic biopsies and 15 biopsies taken at the time of relapse were successfully sequenced. CD20 mutations involving the rituximab epitope were detected in only 1/264 (0.4%) and 1/15 (6%) of the biopsies taken at diagnosis and relapse, respectively. No polymorphic sequence variants were detected in this region. Three patients had malignant cells that were CD20 protein-positive at diagnosis but CD20-negative at relapse. Thus, CD20 mutations involving the rituximab epitope are rare in both de novo and relapsed diffuse large B-cell lymphoma, and do not represent a significant cause of R-CHOP resistance. CD20 protein-negative relapses occur after R-CHOP therapy but their clinical relevance is unknown.

US$19.90

PMID: 19211644

DOI: 10.3324/haematol.2008.001024


Other references

Anonymous, 1943: British Parliamentary And Scientific Committee. Science 97(2517): 280-280

Asimacopoulos, P., J.; Ioannou, N., I.; Toumbis-Ioannou, E.; Morris, M., R., 1993: Allen's test in unconscious patients. The authors present a version of the original Allen test for use in unconscious patients. The original Allen test requires the cooperation of the conscious patient. The authors' version is a fast, simple, cost-effective method that produces t...

Spanos A.; Sedgwick S.G., 1984: Plasmid cloning and expression of the escherichia coli pola positive gene in saccharomyces cerevisiae. The E. coli polA+ gene was subcloned from a specialized .lambda. transducing phage onto a low copy number plasmid. Plasmid-encoded DNA polymerase I was synthesized at 2 to 3 times the wild-type E. coli level, and was biochemically indistinguishabl...

Stange, U.; Führling, C.; Gieseler, H., 2014: Formulation, preparation, and evaluation of novel orally disintegrating tablets containing taste-masked naproxen sodium granules and naratriptan hydrochloride. The purpose of this study was to develop and manufacture novel freeze-dried orally disintegrating tablets (ODTs) for migraine therapy containing taste-masked naproxen sodium and naratriptan hydrochloride. The formulation was optimized based on fre...

Barton Mark; Tyler Noel, 1992: Permeability variation in distributary-channel deposits of seaward and landward-stepping deltaic depositional units, Cretaceous Ferron Sandstone, Utah. AAPG Bulletin 76(8): 1271-1272

Schaffner, M., 1990: Writing job descriptions. The skill of writing job descriptions begins with an understanding of the advantages, as well as the basic elements, of a well written description. The end result should be approved and updated as needed. Having a better understanding of this proc...

Langourov, Mario, 2001: Scuttle flies from caves in the Balkan Peninsula (Diptera: Phoridae). Faunistic data of scuttle flies Triphleba antricola, Triphleba aptina, Triphleba hyalinata, Megaselia fusca, Megaselia halterata, Megaselia longicostalis, Megaselia pleuralis, Megaselia rufipes and Megaselia tenebricola from caves on the territory...

Utsel, S.; Bruce, C.; Pettersson, Törn.; Fogelström, L.; Carlmark, A.; Malmström, E.; Wågberg, L., 2012: Physical tuning of cellulose-polymer interactions utilizing cationic block copolymers based on PCL and quaternized PDMAEMA. In this work, the objective was to synthesize and evaluate the properties of a compatibilizer based on poly(ε-caprolactone) aimed at tuning the surface properties of cellulose fibers used in fiber-reinforced biocomposites. The compatibilizer is a...

Popple, E., 1945: Hertfordshire crustacea. Transactions of the Hertfordshire Natural History Society, 223: 91-96

Oeser, R., 1982: Special stoppering techniques and rooting of imported plants. Kakteen und andere Sukkulenten 33(10): 219-220