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CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes

, : CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes. Colloids and Surfaces. B, Biointerfaces 105: 31-36

This research is aimed to develop a nano-sized supramolecular micelle delivery system of cis-dichlorodiammine platinum (II) (CDDP) in order to achieve the passive tumor targeting. Firstly, star-shaped poly (γ-benzyl-L-glutamate) was synthesized by the ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride initiated with per-6-amino-β-cyclodextrin. After removal of benzyl groups, β-cyclodextrin based seven-armed poly (L-glutamic acid) (β-CD-7PLGA) was obtained. β-CD-7PLGA/CDDP complexes were prepared by the complex reaction between the carboxylic groups of β-CD-7PLGA and CDDP. Further inclusion of β-CD-7PLGA/CDDP complexes with adamantine terminated mPEG (mPEG-Ad) gave CDDP supramolecular micelles (mPEG-Ad@β-CD-7PLGA/CDDP). The formation of mPEG-Ad@β-CD-7PLGA/CDDP supramolecular micelles was confirmed by fluorescence spectrophotoscopy and particle size measurements. All the micelles showed spherical shape, and their sizes increased from 100 to 135 nm with the increase of PLGA arm molecular weight. mPEG-Ad@CD-7PLGA/CDDP micelles showed sustained drug release profiles over 50h in PBS. Compared with CDDP, mPEG-Ad@β-CD-7PLGA/CDDP supramolecular micelles showed essential decreased cytotoxicity to KB cells, suggesting their great potential as the delivery carriers of CDDP.


PMID: 23352945

DOI: 10.1016/j.colsurfb.2012.12.046

Other references

Frank, H., 1954: Nitrogen loss in maturing plants. The loss of total N in the latter part of the vegetative growth period was determined, using Arabidopsis thaliana and 2 varieties of Oenothera suaveolens. In Arabidopsis the maximum N- content was reached on the 85th day of an 110-day culture and...

T.Dahm, 1996: Relative moment tensor inversion based on ray theory; theory and synthetic tests. Geophysical Journal International 124(1): 245-257

Ardin, P.; Peng, F.; Mangan, M.; Lagogiannis, K.; Webb, B., 2016: Using an Insect Mushroom Body Circuit to Encode Route Memory in Complex Natural Environments. Ants, like many other animals, use visual memory to follow extended routes through complex environments, but it is unknown how their small brains implement this capability. The mushroom body neuropils have been identified as a crucial memory circu...

Rampino, T.; Maggio, M.; Soccio, G.; Gregorini, M.; Guidetti, C.; Marasa, M.; Ranghino, A.; Dal Canton, A., 2002: Activation of PPARgamma downregulates MET protooncogene expression and inhibits growth in renal cancer cells. Journal of the American Society of Nephrology 13(Program and Abstracts Issue): 505A, September

Yerevanian, B.I.; Koek, R.J.; Mintz, J., 2003: Lithium, anticonvulsants and suicidal behavior in bipolar disorder. Background: Lithium has been found to be effective in reducing suicide rates during long term treatment of patients with bipolar disorders. Data on the efficacy of anticonvulsant mood stabilizers in reducing suicide risk are sparse. Method: Charts...

Rato, Márcia.G.; Nerlich, A.; Bergmann, Ré.; Bexiga, R.; Nunes, S.F.; Vilela, C.L.; Santos-Sanches, I.; Chhatwal, G.S., 2011: Virulence gene pool detected in bovine group C Streptococcus dysgalactiae subsp. dysgalactiae isolates by use of a group A S. pyogenes virulence microarray. A custom-designed microarray containing 220 virulence genes of Streptococcus pyogenes (group A Streptococcus [GAS]) was used to test group C Streptococcus dysgalactiae subsp. dysgalactiae (GCS) field strains causing bovine mastitis and group C or...

Brugère, J.; Schleinger, M.; Gérard-Marchant, R.; Tubiana, M.; Pouillart, P.; Cachin, Y., 1974: Lymphosarcomas and reticulosarcomas of the upper aerodigestive tract. Natural history and results of radiotherapy. Bulletin du Cancer 61(1): 79-92

Wilcock, B., 1989: The pathology of treatment failure. Proceedings of the annual convention American Association of Bovine Practitioners: (21st) 146-147

Bartram, Edwin B., 1942: Mosses collected by Hawaiian Bog Survey of 1938. Lists 72 spp. and 2 vars. with annotations by Dr. Carl Skottsberg. Campylopus (Eucam-pylopus) tubulosus* (p.324); Grimmia torquata and Ortho-dontium pellucens are added to Hawaiian moss flora.

Altree Williams, S.; Howden, M.E.H.; Keegan, J.T.; Malcolm, H.D.R.; Wyllie, S.G., 1975: Acidic growth inhibitors from peach buds. Plant growth inhibitors in acidic extracts of flower buds from mature peach trees were p-coumaric acid, ferulic acid, an isomeric hydroxymethoxycinnamic acid, a dihydroxycinnamic acid having the properties of 3,5-dihydroxycinnamic acid, and benzoi...