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CTCF: the protein, the binding partners, the binding sites and their chromatin loops


, : CTCF: the protein, the binding partners, the binding sites and their chromatin loops. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 368(1620): 20120369-20120369

CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some tissue-specific, others ultra-conserved. It can act as a transcriptional activator, repressor and insulator, and it can pause transcription. CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies. It can attract many other transcription factors to chromatin, including tissue-specific transcriptional activators, repressors, cohesin and RNA polymerase II, and it forms chromatin loops. Yet, or perhaps therefore, CTCF's exact function at a given genomic site is unpredictable. It appears to be determined by the associated transcription factors, by the location of the binding site relative to the transcriptional start site of a gene, and by the site's engagement in chromatin loops with other CTCF-binding sites, enhancers or gene promoters. Here, we will discuss genome-wide features of CTCF binding events, as well as locus-specific functions of this remarkable transcription factor.

US$19.90

PMID: 23650640

DOI: 10.1098/rstb.2012.0369


Other references

Mallion, J.M.; Asmar, R.; Poggi, L.; Safar, M.; André, J.L.; Balansard, P.; Barrala, A.; Battaglia, C.; Boutarin, J.B.; Chaignon, M., 1989: Arterial pressure--self measurement. Recommendations. French Society for Arterial Hypertension--the Measurement Group. Self-measurement of blood pressure has become widespread in recent years. It may be defined as the measurement of arterial pressure by a conscious and free-willed subject. Self-measurement must remain a medical procedure, which means that doctors...

Rubio-Cabetas, M.; Minot, J.; Voisin, R.E.menjaud, D.S.lesses, G.B.nnet, A., 1999: Resistance response of the Ma genes from a Myrobalan plum to Meloidogyne hapla and M mayaguensis. In 'Myrobalan' plum (Prunus cerasifera Ehr.), Ma1 and Ma2 are single major dominant genes that control the resistance to the predominant root-knot nematode (RKN) species Meloidogyne arenaria (Neal) Chitwood, M. incognita (Kofoid & White)...

Simpson, G.L., 1955: Someone must pay for their care. Journal of the Kentucky State Medical Association 53(7): 601-603

Ramamoorthy, K.; Natarajan, N., 1998: Effect of soaking in methanol on seed germination and vigour in cowpea Savi. Soaking cowpea seeds in methanol for varying durations resulted in loss of germination and vigour and the pattern of decline was comparable with that of accelerated ageing test. It is suggested to use methanol soaking as a stress test for evaluati...

Huang, Kj, 1980: Comprehensive studies on veget. Tai wan yin hang chi kan 31(4): 165-195

Zakharov, V.M., 1961: On changes in conditioned reflex activity of white rats during the action of small doses of internal radiation. Zhurnal Vysshei Nervnoi Deiatelnosti Imeni i P Pavlova 11: 361-369

Higuchi, H., 1997: Population ecology of the stink bug, Piezodorus hybneri (Heteroptera: Pentatomidae), in soyabean fields and its effective egg parasitoid, Telenomus triptus (Hymenoptera: Scelionidae). A study was carried out in Kyushu, Japan, on the life cycle and population dynamics of Piezodorus hybneri (a major pest of soyabeans). The activities of the egg parasitoid, Telenomus triptus, (the major natural enemy of P. hybneri) were studied wi...

D.C.Atel.A.; Bozoky.E., 1961: The origin and prevention of pain in rheumatic diseases. Munchener Medizinische Wochenschrift 103: 1510-1514

Mito, K., 1996: A needle type therapeutic system incorporating laser light and lumin for immunotherapy of cancer growing in deep organs. Lumin is a potent cell-activating agent and a photosensitizer characterized by absorption peaks at 670 nm and 770 nm. It has already been demonstrated that macrophase activity is enhanced greatly by lumin administration with laser light irradiatio...

Watts, R.A.; Paice, E.W.; White, A.G., 1987: Spontaneous fracture of the sternum and sternal tuberculosis. Thorax 42(12): 984-985