geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Calcium-channel blockers do not alter the clinical efficacy of clopidogrel after myocardial infarction: a nationwide cohort study


, : Calcium-channel blockers do not alter the clinical efficacy of clopidogrel after myocardial infarction: a nationwide cohort study. Journal of the American College of Cardiology 57(4): 409-417

The purpose of this study was to determine the risk of adverse cardiovascular events associated with concomitant use of clopidogrel and calcium-channel blockers (CCBs) in patients with myocardial infarction (MI). CCBs inhibit a variety of cytochrome P-450 enzymes, some of which contribute to clopidogrel metabolic activation. This interaction may diminish the efficacy of clopidogrel. All patients surviving 30 days after a first-time MI in the period 2000 to 2006 in Denmark were identified by individual-level linkage of nationwide administrative registers. The cohort was divided into patients treated with and without clopidogrel and followed for 1 year after discharge. The risk of a composite of cardiovascular death, MI, or stroke and the risk of the individual components of the composite end point and all-cause death associated with CCBs were analyzed with multivariable Cox proportional hazard models and in univariate propensity score-matched models. A total of 56,800 patients were included, of whom 24,923 were treated with clopidogrel and 13,380 with CCBs. In the Cox analyses, the risk of the composite end point associated with CCBs was increased in both patients treated and not treated with clopidogrel, with a hazard ratio of 1.15 (95% confidence interval [CI]: 1.07 to 1.24) and 1.05 (95% CI: 1.01 to 1.11), respectively. The increased risk was independent of clopidogrel use; the hazard rate ratio was 1.08 (95% CI: 0.99 to 1.18). Analyses of all additional adverse end points and propensity score-matched models provided similar results. The clinical efficacy of clopidogrel in patients with a recent MI is not modified by concomitant CCB treatment. This potential drug interaction is unlikely to have clinical significance.

US$19.90

PMID: 21251580

DOI: 10.1016/j.jacc.2010.08.640


Other references

de Leeuw, P.W., 1994: Pathophysiology of hypertension in patients on renal replacement therapy. Hypertension is a frequent problem in patients with renal failure, whether or not they are on renal replacement therapy. Little is known, however, about the pathophysiological mechanisms leading to an elevation of blood pressure. Although there is...

Ungar, H., 1951: Transformation of the hepatic vasculature of rats following protracted experimental poisoning with carbon tetrachloride; its possible relation to the formation of urate calculi in the urinary tract. Urate calculi were formed in the urinary bladder of albino rats after the development of coarsely-nodular cirrhosis produced by CCl4 admn. In animals with finely-nodular cirrhosis and with various non-fibrotic lesions developed during the course o...

Woelfing, B.; Traulsen, A.; Milinski, M.; Boehm, T., 2008: Does intra-individual major histocompatibility complex diversity keep a golden mean?. An adaptive immune response is usually initiated only if a major histocompatibility complex (MHC) molecule presents pathogen-derived peptides to T-cells. Every MHC molecule can present only peptides that match its peptide-binding groove. Thus, it...

Buljubasic N.; Marijic J.; Supan D.; Kampine J.P.; Bosnjak Z.J., 1992: Role and regulation of calcium sensitive potassium current in canine coronary smooth muscle. FASEB Journal 6(4): A1544

Golovchenko Xenia; O.C.nnell Suzanne B.; Jarrard Richard D., 1990: Sedimentary response to paleoclimate from downhole logs at Site 693, Antarctic continental margin. Proceedings of the Ocean Drilling Program, Scientific Results 113: 239-251

Campanella L.; Mazzei F.; Sammartino M.P.; Tomassetti M., 1990: New enzyme sensors for urea and creatinine analysis. New selective sensors sensitive to urea or creatinine have been developed and different geometries of the electroenzymatic systems investigated. The sensors were characterised and used to analyse clinical matrices (urines and control sera).

Isaksen, M.L.; Dokland, T.; Lindqvist, B.H., 1993: Characterization of the capsid associating activity of bacteriophage P4's Psu protein. The Psu (Polarity suppression) protein of satellite bacteriophage P4 was first characterized as an anti-terminator of transcription termination in Escherichia coli. Psu is also a structural component of mature P4 capsids, where it is present as a...

Patel, N.; Choudhary, N.; Tompkins, C.; Ammar, K.Afzal.; Tajik, A.Jamil.; Chandrasekaran, K.; Paterick, T.E., 2017: Syncope in Young Women: Broadening the Differential Diagnosis. Syncope is defined as a sudden transient loss of consciousness (TLOC) with concomitant loss of postural tone followed by spontaneous recovery. It is a subset of a broader class of medical conditions, including postural orthostatic tachycardia synd...

Andersen-Ranberg, K.; HØier-Madsen, M.; Wiik, A.; Jeune, B.; Hegedus, L., 2004: High prevalence of autoantibodies among Danish centenarians. The aim of this study was to investigate the prevalence of organ and nonorgan specific autoantibodies in relation to disability and comorbidity in an unselected population of centenarians. A population-based survey of all persons living in Denmark...

Okada, E., 1980: Prediction of pregnancy toxemias - the significance of the roll-over test. Nursing Technique 26(13): 1717-1724