+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cardiac hormones inhibit proliferation of pancreatic cancer but not normal cells

, : Cardiac hormones inhibit proliferation of pancreatic cancer but not normal cells. European Journal of Clinical Investigation 40(8): 706-712

Four cardiac hormones, i.e. atrial natriuretic peptide (ANP), vessel dilator, long-acting natriuretic peptide (LANP) and kaliuretic peptide (KP), have anticancer effects both in vitro and in vivo. The sustained decrease in number of human pancreatic adenocarcinoma cells for 3 days secondary to the four hormones noted previously suggests a decrease in proliferation of pancreatic cancer cells not eliminated after initial treatment. Four cardiac hormones were evaluated for their ability to directly decrease proliferation of human pancreatic cancer cells with comparison of their effects on proliferation on normal human lung, kidney, prostate and endothelial cells. ANP, LANP, vessel dilator and KP decreased the proliferation of viable human pancreatic adenocarcinoma cells by 39%, 73%, 26% and 32% respectively at their 0.01 microM concentrations compared with the proliferation of untreated pancreatic cancer cells. Maximal inhibition of proliferation (81%) occurred with LANP at its 0.1 microM concentration in dose-response studies. At these same concentrations, there was no decrease in proliferation of human kidney, lung, prostate or endothelial cells compared with untreated kidney, lung, prostate or endothelial cells. Four cardiac hormones have strong anti-proliferative effects on human pancreatic adenocarcinoma cells while sparing human kidney, lung, prostate and endothelial cells from a similar strong anti-proliferative effect. This anti-proliferative effect on pancreatic cancer cells helps to explain why human pancreatic cancers in vivo treated with the cardiac hormones decrease to less than 10% of the volume of untreated pancreatic cancers as they proliferate less.


PMID: 20546014

DOI: 10.1111/j.1365-2362.2010.02309.x

Other references

Kitagawa R.; Nishido H., 1995: Transition of hydrothermal activities in the Chugoku Province. Shigen Chishitsu = Journal of the Society of Resource Geology 45(4(252)): 269-270

Ernst V., 1978: Glucose 6 phosphate in the regulation of protein synthesis initiation in reticulocyte lysates. Federation Proceedings 37(6): 1792

Kar, K.; Sur, R.N.; Pradhan, S.N., 1969: Depressor response to noradrenaline in hypothermic cats. Japanese Journal of Pharmacology 19(1): 68-73

Janischewsky, M., 1903: Die Fauna des Carbonkalkes im Gebiete des Flusses Schartymka am ostlichen Abfalle des Urals. Trudui Kazan: 398 pp.

Fu, H.; Chen, H.; Zhang, X.; Qu, Y.; Marko, J.F.; Yan, J., 2011: Transition dynamics and selection of the distinct S-DNA and strand unpeeling modes of double helix overstretching. Recent studies have revealed two distinct pathways for the DNA overstretching transition near 65 pN: ‘unpeeling’ of one strand from the other, and a transition from B-DNA to an elongated double-stranded ‘S-DNA’ form. Howeve...

Ringel, F.; Ingerl, D.; Ott, S.; Meyer, B., 2009: VarioGuide: a new frameless image-guided stereotactic system--accuracy study and clinical assessment. VarioGuide (BrainLAB AG, Feldkirchen, Germany) is a new system for frameless image-guided stereotaxy. In the present study, we aimed to assess target point accuracy in a laboratory setting and the clinical feasibility of the system. Using the phan...

Bilsker, D.; Goldner, E.M.; Jones, W., 2007: Health service patterns indicate potential benefit of supported self-management for depression in primary care. To examine health service delivery in a Canadian province (British Columbia) to consider how Canadian health care services might be developed to best address the large number of individuals with mildly to moderately severe depressive illnesses. We...

Yano, T.; Matsui, T.; Tamura, A.; Uji, M.; Tsukita, S., 2014: The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK. Epithelial cells characteristically have noncentrosomal microtubules that are arranged in the apicobasal direction. In this paper, we examined cell sheets formed by an epithelial (Eph4) cell line by structure illumination microscopy and found a pr...

Olteanu, M.; Pop, M.; Horge, I.; Mitrea, C.; Dumitru, D., 1980: Different indications and results of operations for artificial crystalline lens implantation. Revista de Chirurgie, Oncologie, Radiologie, O. R. L., Oftalmologie, Stomatologie. Seria: Oftalmologie 24(3): 211-214

Gusenleitner, J., 1995: Die Antepipona-Arten Nordafrikas (Hymenoptera, Vespoidea, Eumenidae). Keys to all known species of the genus Antepipona SAUSSURE which occur in North Africa are presented, completed with dates of descriptions, distributions and other remarks. A new established synonym is Antepipona deflenda (S. S. SAUNDERS 1853) = A...