+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cell penetrating elastin-like polypeptides for therapeutic peptide delivery

, : Cell penetrating elastin-like polypeptides for therapeutic peptide delivery. Advanced Drug Delivery Reviews 62(15): 1486-1496

Current treatment of solid tumors is limited by side effects that result from the non-specific delivery of drugs to the tumor site. Alternative targeted therapeutic approaches for localized tumors would significantly reduce systemic toxicity. Peptide therapeutics are a promising new strategy for targeted cancer therapy because of the ease of peptide design and the specificity of peptides for their intracellular molecular targets. However, the utility of peptides is limited by their poor pharmacokinetic parameters and poor tissue and cellular membrane permeability in vivo. This review article summarizes the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutic peptides (TP), and the use of cell penetrating peptides (CPP) to enhance the intracellular delivery of the ELP-fused TPs. CPP-fused ELPs have been used to deliver a peptide inhibitor of c-Myc function and a peptide mimetic of p21 in several cancer models in vitro, and both polypeptides are currently yielding promising results in in vivo models of breast and brain cancer.


PMID: 20478348

DOI: 10.1016/j.addr.2010.05.003

Other references

Blaustein M.P., 1982: Sodium calcium exchange in barnacle muscle and squid axons the role of atp. Journal of General Physiology 80(6): 3A, E.; Stanley, H.Eugene.; Sciortino, F., 2002: Configuration space connectivity across the fragile-to-strong transition in silica. We present a numerical analysis for SiO (2) of the fraction of diffusive direction f(diff) for temperatures T on both sides of the fragile-to-strong crossover. The T dependence of f(diff) clearly reveals this change in dynamical behavior. We find...

Klapetek, I., 1965: Psychomotor, or temporal epilepsy. Klinicheskaia Meditsina 43(9): 71-78

Freund, J.; Thomson, K.J., 1945: A Simple, Rapid Technic Of Preparing Water-In-Oil Emulsions Of Penicillin, Drugs And Biologics. Describe a technic which can be carried out readily at clinic or bedside.

Evenden, James C., 1926: The pine butterfly, Neophasia menapia Felder. The different stages, seasonal biology and habits, natural enemies, distribution, and economic importance are briefly described. A record of the successful reduction of an epidemic of this insect by natural enemies is given.

Anonymous, 1927: Scholarships And Grants In Aid Of Scientific Research. British Medical Journal 1(3453): 477-477

Fraser, D., 2010: Are you an advocate for your patient?. Neonatal Network 28(5): 279-279

Greenberg R.; Cassel J.; Satinsky V.P., 1973: Histological studies of various implanted anode and cathode electrodes. Medical Instrumentation 7(1): 57-58

Maitland, P.S.; Lyle, A.A.; Barnett, I.K.O., 1990: Status of the schelly coregonus lavaretus l. in red tarn cumbria england uk. The fish population of Red Tarn was studied and the continued presence there of the schelly confirmed. This is an important site for fish in the British Isles and, though apparently under no special threat, warrants careful conservation in the fut...

Hendry, P.I., 1974: The use of patients' data for laboratory and interlaboratory standardization. Rinsho Byori. Japanese Journal of Clinical Pathology 22(4): 269-283