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Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte

, : Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte. Endocrine Journal 60(6): 697-708

Experimental transplantation of endocrine tissues has led to significant advances in our understanding of endocrinology and metabolism. Endocrine cell transplantation therapy is expected to be applied to the treatment of metabolic endocriopathies. Restoration of functional pancreatic beta-cell mass or of functional adipose mass are reasonable treatment approaches for patients with diabetes or lipodystrophy, respectively. Human induced pluripotent stem (iPS) cell research is having a great impact on life sciences. Doctors Takahashi and Yamanaka discovered that the forced expression of a set of genes can convert mouse and human somatic cells into a pluripotent state [1, 2]. These iPS cells can differentiate into a variety of cell types. Therefore, iPS cells from patients may be a potential cell source for autologous cell replacement therapy. This review briefly summarizes the current knowledge about transplantation therapy for diabetes mellitus, the development of the endocrine pancreas and adipocytes, and endocrine-metabolic disease-specific iPS cells.


PMID: 23719783

Other references

Chan, Y.C.; Ting, C.W.; Ho, P.; Poon, J.T.; Cheung, G.C.; Cheng, S.W., 2008: Ten-year epidemiological review of in-hospital patients with Marfan syndrome. Marfan syndrome is a connective tissue disorder with a worldwide prevalence of 1 in 5,000, without any racial predilection. Major cardiovascular manifestations of Marfan disease often require surgical intervention. The aim of this study was to exa...

Agnes, F.B.glioni, T.B.nini, P., 1974: Calcium tolerance test according to Klotzs method applied to calving cow. Archivio veterinario italiano: 25 (3 4) 81-95

Leigh Brown, A.J., 1990: Evolutionary relationships of the human immunodeficiency viruses. The rapid accumulation of nucleotide sequence data on viral genes has allowed, for the first time, the development of detailed phylogenies of viruses based on an objective criterion. This has been demonstrated clearly in the recent analysis of the...

Salikhova, S.Kh.; Tumakov, S.A.; Lukova, N.B., 1980: Serum lactate dehydrogenase activity and isoenzymatic spectrum in primary glaucoma. Vestnik Oftalmologii: 8-11

Gaggermeier, Hansjorg, 2000: Rubus sendtneri, an unnoticed species in Eastern Bavaria, Germany. The regional taxon Rubus sendtneri (Rosaceae, genus Rubus, subgenus Corylifolii) was already described by A. Progel. The since neglected taxon is morphologically described and pictured. The recent districution in the region is commented on and map...

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Craven, S.A., 1999: Rugby injuries and the high tackle. South African Medical Journal 89(9): 916-916

Sakamoto, M.; Huang, Y.; Ohnishi, M.; Umeda, M.; Ishikawa, I.; Benno, Y., 2004: Changes in oral microbial profiles after periodontal treatment as determined by molecular analysis of 16S rRNA genes. Terminal RFLP (T-RFLP) analysis was used to investigate changes in the oral microbiota in saliva and subgingival plaque samples from one patient with aggressive periodontitis (subject A) and two patients with chronic periodontitis (subjects B and...

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