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Cell-mediated immunity in human brucellosis


, : Cell-mediated immunity in human brucellosis. Microbes and Infection 13(2): 134-142

Brucella can parasitize within human antigen-presenting cells modifying phagocytosis, phagolysosome fusion, antigen presentation, cytokine secretion, and apoptosis. Subversion of innate immune mechanisms by Brucella leads to defective Th1 immune responses and T-cell anergy in chronic brucellosis patients. This review summarizes the cellular immune responses in brucellosis, based on data derived exclusively from human cells or cell lines.

US$19.90

PMID: 21034846

DOI: 10.1016/j.micinf.2010.10.015


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