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Challenges in oral antiplatelet therapy: ST-segment elevation myocardial infarction

, : Challenges in oral antiplatelet therapy: ST-segment elevation myocardial infarction. American Journal of Cardiology 104(5 Suppl): 39c-43c

ST-segment elevation myocardial infarction (STEMI) poses unique challenges to cardiologists because short- and long-term therapeutic plans occur rapidly and often with limited information. Dual oral antiplatelet therapy is a mainstay of treatment, although limitations exist for all agents. Simple algorithms will improve prompt use of these medications in emergency room settings, although simplicity may not be possible for high-risk patient populations, especially those with an increased risk of bleeding. Caution is therefore warranted against the usual process of generalization of clinical trial results to the entire spectrum of patients with STEMI. This concern is especially important for those at highest risk for bleeding, where high-dose clopidogrel or short- or long-term prasugrel may carry significant risks. Maximizing the efficacy and safety of long-term oral antiplatelet therapy requires individualization of therapy, heightened clinical judgement, and caution.


PMID: 19695360

DOI: 10.1016/j.amjcard.2009.06.014

Other references

Yang W.H.; Sussman G.L.; Kanigsberg H.D.; Karsh J.; Zimmerman B., 1989: Melkersson rosenthal syndrome mrs responsive to clofazimine. Clinical & Investigative Medicine 12(SUPPL 4): B5

Williams, R.C.; Fraser, D., 1956: Structural and functional differentiation in T2 bacteriophage. Particles of T2 bacteriophage and T2 ghosts were disjoined into several component parts by treating them to cycles of alternate freezing and thawing. The distinguishable components are: intact heads, intact tails, head membranes, cross sections of...

Koyama, K.; Takahashi, J.; Ochiai, R.; Takeda, J.; Nagano, M., 1990: Evaluation of esophageal temperature measured by gastric tube with thermistor. Canadian Journal of Anaesthesia 37(4 Pt 2): S111-S111

Esteras-Chopo, A.; Morra, G.; Moroni, E.; Serrano, L.; Lopez de la Paz, M.; Colombo, G., 2008: A molecular dynamics study of the interaction of D-peptide amyloid inhibitors with their target sequence reveals a potential inhibitory pharmacophore conformation. The self-assembly of soluble proteins and peptides into beta-sheet-rich oligomeric structures and insoluble fibrils is a hallmark of a large number of human diseases known as amyloid diseases. Drugs that are able to interfere with these processes...

Curi, R.; Hell, N.S.; Timo Iaria, C., 1987: Reversibility of the metabolic adaptations to meal-feeding in rats. Experimental results indicated that in rats, adaptations in stomach weight (g/100 g body weight), glycaemia (mg/100 ml), hepatic glycogen (mg/100 mg), free fatty acids ( mu mol/litre) and plasma insulin ( mu units/ml) are defined for a particular...

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Albertsen, K.; Roth, H.P.; Abbott, W.E., 1962: Effect of aldosterone antagonist-induced sodium depletion. Abstract The study suggests that Na restriction and the administration of a natriuretic agent to a patient with cirrhosis and ascites led to hypo-natremia, hypotension, uremia and death.

Wianny, F.; Perreau, C.; Hochereau de Reviers, M.T., 1997: Proliferation and differentiation of porcine inner cell mass and epiblast in vitro. The proliferation rate and differentiation state were investigated in porcine inner cell masses (ICMs) and epiblasts in vitro. ICMs isolated from early blastocysts (Day 7 of pregnancy) and epiblasts isolated from preelongated blastocysts (Day 11 o...

Brown, G.A.; Berger, H.M.; Brueton, M.J.; Scott, P.H.; Wharton, B.A., 1989: Nonlipid formula components and fat absorption in the low-birth-weight newborn. The relationship between nonlipid formula components and fat absorption in newborns is largely uninvestigated. Two formulas of identical fat blend but different protein quality and acid-base properties were fed to two groups of babies from birth a...

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