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Changes of Foxp3(+); regulatory T cells in patients with acute coronary syndrome


, : Changes of Foxp3(+); regulatory T cells in patients with acute coronary syndrome. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27(8): 893-895

To investigate the changes of Foxp3(+); (including CD4(+);Foxp3(+); and CD4(+);CD25(+);Foxp3(+);) regulatory T cells (Tregs) in patients with acute coronary syndrome (ACS). Forty-four ACS patients, twenty patients with stable angina (SA) and twenty-four control patients were enrolled. The percentages of the peripheral Tregs, Foxp3 mRNA and plasma level of TGF-β1 were measured by flow cytometry, real-time quantitative PCR and ELISA. The percentages of CD4(+);CD25(+);Foxp3(+); Tregs and CD4(+);Foxp3(+); Tregs, Foxp3 mRNA and plasma level of TGF-β1 significantly decreased in the ACS group as compared with those in the SA group and the controls (P<0.05), while there was no significant difference in the percentage of CD4(+);CD25(+); Tregs among all three groups. There are less Foxp3(+);Tregs, perhaps with impaired function, in ACS patients, which might contribute to plaque destabilization.

US$29.90

PMID: 21806889


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