geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Childhood obesity in Asian Indians: a burgeoning cause of insulin resistance, diabetes and sub-clinical inflammation


, : Childhood obesity in Asian Indians: a burgeoning cause of insulin resistance, diabetes and sub-clinical inflammation. Asia Pacific Journal of Clinical Nutrition 17 Suppl 1: 172-175

Recent data indicate a rise in obesity both in children and adolescents in developing countries. The overall prevalence of overweight/obesity in urban children in New Delhi has shown an increase from 16% in 2002 to about 24% in 2006-2007. Our recent data show that the prevalence among adolescent children was 29% in private schools and 11.3% in government funded schools. While India already has highest number of patients with type 2 diabetes mellitus (T2DM) globally, rapid rise of obesity in children is the prime reason for increasing insulin resistance, the metabolic syndrome, dyslipidemia, polycystic ovarian syndrome and raised levels of C-reactive protein. Excess body fat, thick truncal subcutaneous fat, and abdominal adiposity are important predisposing factors for development of insulin resistance in Asian Indian children. As compared to other ethnic groups, children with ancestral origin in South Asia manifest adiposity, insulin resistance and metabolic perturbations earlier in life and these derangements are of higher magnitude than white Caucasian children. Since the metabolic syndrome and obesity track into adulthood, these clinical entities need to be recognized early for effective prevention of T2DM and coronary heart disease. Therapeutic lifestyle changes, maintenance of high levels of physical activity and normal weight are most important prevention strategies. Both high-risk surveillance and cost-effective population intervention programs are urgently needed. In this context, we have launched one of the largest program ("MARG", The Path) to curb childhood obesity in India.

US$29.90

PMID: 18296330


Other references

Tamura, S.; Nakamori, S.; Kuroki, T.; Sasaki, Y.; Furukawa, H.; Ishikawa, O.; Imaoka, S.; Nakamaura, Y., 1997: Association of cumulative allelic losses with tumor aggressiveness in hepatocellular carcinoma. Background/Aims: Loss of heterozygosity on various chromosomal arms has been reported in hepatocellular carcinoma and a multistep accumulation of genetic alteration has become accepted as the mechanism underlying progression of the disease. Althou...

Tzanoulinou, S.; García-Mompó, C.; Castillo-Gómez, E.; Veenit, V.; Nacher, J.; Sandi, C., 2015: Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala. Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are oft...

Seres, D.S.; Resurreccion, L.B., 2005: Kwashiorkor: dysmetabolism versus malnutrition. Nutrition in Clinical Practice 18(4): 297-301

Fernandez Lafuente, R.; Hernandez Justiz, O.; Mateo, C.; Terreni, M.; Fernandez Lorente, G.; Moreno, M.A.; Alonso, J.; Garcia Lopez, J.L.; Guisan, J.M., 2001: Biotransformations catalyzed by multimeric enzymes: Stabilization of tetrameric ampicillin acylase permits the optimization of ampicillin synthesis under dissociation conditions. The importance of the stabilization of the quaternary structure of multimeric enzymes has been illustrated using a model reaction with great industrial relevance: the enzymatic synthesis of ampicillin from 6-amino penicillanic acid (6APA) and phen...

Lotem, A.; Fishman, M.A.; Stone, L., 2003: From reciprocity to unconditional altruism through signalling benefits. Cooperation among genetically unrelated individuals is commonly explained by the potential for future reciprocity or by the risk of being punished by group members. However, unconditional altruism is more difficult to explain. We demonstrate that...

Wilson, R.; Derrett, S.; Hansen, P.; Langley, J., 2013: Retrospective evaluation versus population norms for the measurement of baseline health status. Patient recall or the application of population norms are commonly used methods to estimate (unobservable) health status prior to acute-onset illness or injury; however, both measures are potentially subject to bias. This paper reports tests of th...

Castle, P.H.J., 1970: Distribution, larval growth, and metamorphosis of the eel Derichthys serpentinus Gill, 1884 (Pisces: Derichthyidae). Copeia, 444452

Thomas, S., 2007: The Oslo Ministerial Declaration. Lancet 369(9580): 2159-2159

Dartey, C.K.; Higgins, J.D.IIi; Bruce, R.D.; Burruano, B.T., 2002: Stable salad dressings. The present invention provides a stable foodstuffs which contain a cholesterol lowering amount of a sterol or stanol ester, crystal fat inhibitors and emulsifiers. The foodstuffs, including salad dressings are stable even when refrigerated.

Baev, K.V.; Vasilenko, D.A.; Marlinskiĭ, V.V., 1983: Depolarization of primary afferents induced by selective activation of propriospinal tracts. Primary afferent depolarization (PAD) in the lumbosacral enlargement of the spinal cord evoked by selective activation of propriospinal (PS) pathways was studied in anesthetized cats. Activation of PS pathways in the lateral funiculus was more eff...