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Chromatin dynamics during repair of chromosomal DNA double-strand breaks

, : Chromatin dynamics during repair of chromosomal DNA double-strand breaks. Epigenomics 1(2): 371-385

The integrity of a eukaryotic genome is often challenged by DNA double-strand breaks (DSBs). Even a single, unrepaired DSB can be a lethal event, or such unrepaired damage can result in chromosomal instability and loss of genetic information. Furthermore, defects in the pathways that respond to and repair DSBs can lead to the onset of several human pathologic disorders with pleiotropic clinical features, including age-related diseases and cancer. For decades, studies have focused on elucidating the enzymatic mechanisms involved in recognizing, signaling and repairing DSBs within eukaryotic cells. The majority of biochemical and genetic studies have used simple, DNA substrates, whereas only recently efforts have been geared towards understanding how the repair machinery deals with DSBs within chromatin fibers, the nucleoprotein complex that packages DNA within the eukaryotic nucleus. The aim of this review is to discuss our recent understanding of the relationship between chromatin structure and the repair of DSBs by homologous recombination. In particular, we discuss recent studies implicating specialized roles for several, distinct ATP-dependent chromatin remodeling enzymes in facilitating multiple steps within the homologous recombination process.


PMID: 20495614

DOI: 10.2217/epi.09.22

Other references

Moutou, Francois, 2000: Une vigilance operationnelle: Le cas de la fievre aphteuse. Foot-and-mouth disease (FMD) is an animal disease from viral origin concerning mostly domestic ruminants and swine. Its historical and economical importance in our countries is well known. During 30 years, like in France, the use of a trivalent va...

Schneider, J.R., 1987: Is caffeinated coffee consumption a risk factor for coronary heart disease?. Focus on Critical Care 14(5): 26-33

Joshi, S.S.; Bhoop Singh; Anantwar, L.G.; Awaz, K.B.; Rajguru, D.N.; Ali, M.S., 1993: Clinico-pathology and biochemical alterations in Trypanosoma evansi infection (surra) in buffaloes. The characteristic signs of T. evansi infection were a sudden drop in milk yield, anorexia, lacrimation and nasal discharge. There were anaemic changes and a significant decrease in blood glucose (43.28 +or-0.12 mg/dl), total serum protein (7.26 +...

Bernhardt, P.W.; Wang, H.Judy.; Zhang, D., 2013: Flexible Modeling of Survival Data with Covariates Subject to Detection Limits via Multiple Imputation. Models for survival data generally assume that covariates are fully observed. However, in medical studies it is not uncommon for biomarkers to be censored at known detection limits. A computationally-efficient multiple imputation procedure for mod...

Derave, W.; Straumann, N.; Olek, R.A.; Hespel, P., 2006: Electrolysis stimulates creatine transport and transporter cell surface expression in incubated mouse skeletal muscle: potential role of ROS. Electrolysis stimulates creatine transport and transporter cell surface expression in incubated mouse skeletal muscle: potential role of ROS. Am J Physiol Endocrinol Metab 291: E1250-E1257, 2006. First published July 18, 2006; doi:10.1152/ajpendo...

Shimakage, M.; Sakamoto, H.; Harada, S.; Sasagawa, T.; Kodama, K., 2007: Expression of the Epstein-Barr virus in lymphoproliferative diseases of the lung. There have been few studies regarding the etiology of lymphoproliferative disorders of the lung. To examine the possible involvement of the Epstein-Barr virus (EBV) in these diseases, EBV mRNAs, proteins and DNA, were detected. Two non-Hodgkin&ap...

Miyazaki, C.; Redfield, M.M.; Powell, B.D.; Lin, G.M.; Herges, R.M.; Hodge, D.O.; Olson, L.J.; Hayes, D.L.; Espinosa, R.E.; Rea, R.F.; Bruce, C.J.; Nelson, S.M.; Miller, F.A.; Oh, J.K., 2010: Dyssynchrony indices to predict response to cardiac resynchronization therapy: a comprehensive prospective single-center study. Circulation. Heart Failure 3(5): 565-573

Les, M.; Gauca, C.; Popirlan, G.; Morarescu, R.; Vasiliu, C., 1977: Effect of fertilizer on yield and quality of fibre flax. In field trials at Raucesti in 1971-5, fibre flax was given 48 kg P2O5 + 60 kg K2O + 0, 30, 90 or 120 kg N/ha with or without 7.5 t CaCO3/ha. Straw yields increased from 4.18 t/ha without N to 5.46 t with 120 kg N/ha and were increased by applicat...

Baker, F.C., 1918: Further notes on the Mollusca of Oneida Lake, New York; the Mollusks of Lower South Bay. Nautilus Boston Mass, 31 81-93

Alexandrova, E.A.; Spasov, A.A.; Anisimova, V.A., 1998: Effects of imidazo- benzimidazo-lines on the membrane calcium transport. Journal of Molecular & Cellular Cardiology 30(6): A133, June