geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Chronic valproate or levetiracetam treatment does not influence cytokine levels in humans


, : Chronic valproate or levetiracetam treatment does not influence cytokine levels in humans. Seizure 23(8): 666-669

There is growing evidence that complex interactions between seizures and the immune system shape the course of epilepsy. However, systematic analyses of the effects of antiepileptic drugs (AED) on the immune system in humans are rare. We performed a prospective study on the influence of the widely used AED valproate and levetiracetam on interictal immunological parameters. 36 patients were prospectively included. 15 were started on valproate (5 female (33%), age 54±27 years, 12 (80%) on monotherapy), 21 on levetiracetam (10 female (48%), age 45±19 years, 17 (81%) on monotherapy). Before treatment and after 3 months, we performed a differential blood count and analyzed the distribution of CD3(+)CD4(+)-, CD3(+)CD8(+)- and CD4(+)CD25(+)-leukocyte subsets using flow cytometry. In addition, we determined the concentrations of IL-1β, IL-6, TNF-α and MCP-1 in the peripheral blood using ELISAs. Valproate intake resulted in a significant decrease of the total white blood count (6.96±1.23/nl vs. 6.13±1.57/nl, p=0.026) and of absolute count and percentage of neutrophils (4.60±1.05/nl vs. 3.69±1.30/nl, p=0.01; 65.4±7.9% vs. 59.5±11.5%, p=0.01, respectively). The percentage of CD3(+)CD4(+)-lymphocytes dropped significantly (50.4±10.9% vs. 45.3±12.3%, p=0.002). Levetiracetam treatment resulted in a decrease of the percentage of CD4(+)CD25(+)-lymphocytes (26.1±8.0% vs. 21.5±9.2%, p=0.01) but did not significantly alter absolute counts. Neither valproate nor levetiracetam were associated with significant changes in cytokines. Valproate intake results in profound changes of white blood cell count and subset distribution. Cytokine levels were not influenced by valproate or levetiracetam.

US$19.90

PMID: 24880639

DOI: 10.1016/j.seizure.2014.04.011


Other references

Relini, G.; Fabi, G.; Neves dos Santos, M.; Moreno, I.; Charbonnel, E., 2008: Fisheries and their management using artificial reefs in the northwestern Mediterranean Sea and southern Portugal. American Fisheries Society Symposium 49. 1

Dupont, W.D.; Rogers, L.W.; Vander Zwaag, R.; Page, D.L., 1980: The epidemiologic study of anatomic markers for increased risk of mammary cancer. On the assumption that both the lobular and intraductal atypical lesions of the breast are precancerous in nature, a group of 572 such patients have been closely followed during the past 12 years. Thirty-four patients eventually developed cancer d...

Hunt, K., 1985: The elderly. Uncle Sam is tightening the screws on them--and you. Medical Economics 62(9): 62-4, 67-8, 72

Bisping, G.; Lügering, N.; Lütke-Brintrup, S.; Pauels, H.G.; Schürmann, G.; Domschke, W.; Kucharzik, T., 2001: Patients with inflammatory bowel disease (IBD) reveal increased induction capacity of intracellular interferon-gamma (IFN-gamma) in peripheral CD8+ lymphocytes co-cultured with intestinal epithelial cells. Intestinal epithelial cells seem to play a key role during IBD. The network of cellular interactions between epithelial cells and lamina propria mononuclear cells is still incompletely understood. In the following co-culture model we investigated...

Bandyukova, V.; Khalmatov, K.; Alimov, K., 1969: Flavonoids of Centaurea depressa. Chemistry of Natural Compounds 5(4): 274-275

Oluoha, U.; Ugochukwu, E.N., 1991: Isolation and kinetic properties of phosphorylase from yellow yam tuber (Dioscorea cayenensis). Two forms of alpha -glucan phosphorylase were isolated from D. cayenensis by ammonium sulphate gradient solubilization and further purified using starch adsorption and ion exchange chromatography on DEAE-Sephadex A-25 column. Fraction DC1 was puri...

Job C.K., 1979: Pathological and immunological basis of medical intervention in leprous neuritis. International Journal of Leprosy & Other Mycobacterial Diseases 47(2 SUPPL): 426

Jorgensen, O.; Hvingel, C.; Moller, P.; Treble, M., 2005: Identification and mapping of bottom fish assemblages in Davis Strait and southern Baffin Bay. The bathymetry of Baffin Bay, with shallow sills both to the north and south, creates a relatively isolated body of deep polar water, unique among the Arctic Seas. During 263 trawl hauls completed during October 1999 and September to November 2001...

Mueller W.F.; Mueller G., 1984: Geometry of coherent mixing in clinopyroxenes as a function of elementary cell measurements. Fortschritte der Mineralogie, Beiheft 62(1): 167-168

Bauman, A.E.; Nelson, D.E.; Pratt, M.; Matsudo, V.; Schoeppe, S., 2006: Dissemination of physical activity evidence, programs, policies, and surveillance in the international public health arena. The concepts of dissemination can be applied to the international challenges of promoting physical activity. With the 2004 release of the World Health Organization Global Strategy for Diet and Physical Activity, risk factor reduction and noncommu...