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Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans

, : Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans. Alzheimer's & Dementia 6(3): 239-246

The Clinical Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has provided clinical, operational, and data management support to ADNI since its inception. This article reviews the activities and accomplishments of the core in support of ADNI aims. These include the enrollment and follow-up of more than 800 subjects in the three original cohorts: healthy controls, amnestic mild cognitive impairment (now referred to as late MCI, or LMCI), and mild Alzheimer's disease (AD) in the first phase of ADNI (ADNI 1), with baseline longitudinal, clinical, and cognitive assessments. These data, when combined with genetic, neuroimaging, and cerebrospinal fluid measures, have provided important insights into the neurobiology of the AD spectrum. Furthermore, these data have facilitated the development of novel clinical trial designs. ADNI has recently been extended with funding from an NIH Grand Opportunities (GO) award, and the new ADNI GO phase has been launched; this includes the enrollment of a new cohort, called early MCI, with milder episodic memory impairment than the LMCI group. An application for a further 5 years of ADNI funding (ADNI 2) was recently submitted. This funding would support ongoing follow-up of the original ADNI 1 and ADNI GO cohorts, as well as additional recruitment into all categories. The resulting data would provide valuable data on the earliest stages of AD, and support the development of interventions in these critically important populations.


PMID: 20451872

DOI: 10.1016/j.jalz.2010.03.006

Other references

Patrick-Heselton, J., 2012: Faecal incontinence in critical illness. Diarrhoea is a common problem in ICUs, occurring in as many as half of patients who are critically ill. There is a lack of specific guidance on the management of faecal incontinence in these patients. A literature review was used to identify best...

Kayar S.R.; Banchero N., 1985: Volume overload hypertrophy elicited by cold and its effects on myocardial capillarity. Capillarity and fiber cross-sectional areas were measured in the hearts of 12 male guinea pigs exposed to cold (5 .+-. C) early during growth for 4-18 wk. Hearts were perfusion fixed via the aorta with a 2.5% glutaraldehyde and 1% formal...

Sykes, E.M., 2014: Interstitial irradiation therapy in carcinoma originating at the limbus; report of two cases treated with radium element seeds. Texas State Journal of Medicine 42: 376-380

Vilibic, I., 2003: An analysis of dense water production on the North Adriatic shelf. The aim of this paper is to investigate the mechanism of dense water formation in the northern shelf region of the Adriatic Sea and its spreading towards the Middle and South Adriatic. The analyses encompass temperature, salinity, sigma-t and diss...

López López, J.R.; González Benavides, J., 1985: Pityriasis versicolor in children. Four cases in children aged 2-5 months are reported. The occurrence of pityriasis versicolor [Malassezia furfur] in this age group is discussed.

Aragão, E.Ingrid.Souza.; Portugal, Fávia.Batista.; Campos, Mônica.Rodrigues.; Lopes,; Fortes, S.Lúcia.Correia.Lima., 2017: Different patterns of social support perceived and their association with physical (hypertension, diabetes) or mental diseases in the context of primary health care. This work discusses the relationship between hypertension, diabetes, anxiety, depression, and social support in primary health care. This research aimed to identify the association between physical disease, mental disease, support network and perc...

Besedovsky, H.O.; del Rey, A., 2001: The cytokine-HPA axis feed-back circuit. Due to their anti-inflammatory effects and their capacity to affect the synthesis of most cytokines and the Th1/Th2 balance, endogenous glucocorticoids contribute to control the basal operation of immune cells. Immune processes result in the produ...

Oliveira, A.Cristina.; Lopes, A.Cristine.Souza.; Paiva, M.Henriqueta.Rocha.Siqueira., 2009: Occupational accidents due to exposure to biological material in the multidisciplinary team of the emergency service. This transversal, survey-based research was carried out with a multiprofessional emergency care team in Belo Horizonte, between June and December 2006. The study aimed at estimating the incidence of occupational accidents by exposure to biological...

Schwartz, A.Jay., 2010: Education: an essential leg for anesthesiology's four-legged stool!. Anesthesiology 112(1): 3-5

Ahn, I.; Le, B.V.n; Gendy, C.V.n, K., 1996: Direct somatic embryogenesis through thin cell layer culture in Panax ginseng. Direct somatic embryos were differentiated on cotyledon transverse Thin Cell Layers (tTCLs) of Panax ginseng after 9 weeks in the Murashige and Skoog basal (MS) medium containing 2,4-D (5 micromolar). When MS medium containing 2,4-D (5 micromolar)...