+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Clinical efficacy of kanamycin for Mycobacterium avium complex disease

, : Clinical efficacy of kanamycin for Mycobacterium avium complex disease. Yakugaku Zasshi 128(3): 451-460

No previous reports have compared clarithromycin (CAM), rifampicin (RFP) and ethambutol (EB) containing regimens with and without an aminoglycoside antibiotic kanamycin (KM) for the treatment of pulmonary Mycobacterium avium complex (MAC) disease. We conducted a retrospective study to investigate the clinical efficacy of KM using data from 40 patients who received combined chemotherapy for MAC disease with or without KM in the National Hospital Organization Tokyo Hospital from July, 1999 to December, 2005. All patients were administered CAM, RFP and EB for 6 to 12 months, and 20 of the 40 simultaneously received combined chemotherapy with KM. The difference in the backgrounds of the groups was not statistically significant. The improvement rates of clinical symptoms and radiological findings were significantly higher in the KM-treated group than in the KM-untreated group (75% versus 35% and 80% versus 25%). Moreover, the sputum relapse rate was significantly lower in the KM-treated group (18% versus 75%). However, there were no significant differences in the sputum conversion rate (55% with KM versus 40% without KM). As for adverse reactions, there were no significant differences between the groups. Furthermore, we examined time-kill kinetics of KM and streptomycin (SM) against a clinical isolate of M. avium. Most M. avium was killed by KM and SM at concentrations higher than MIC (8 microg/ml), and concentration- and time-dependent killing by KM and SM were almost identical. These observations indicate that KM is effective for treatment of patients with MAC disease.


PMID: 18311066

Other references

Hassan, N.Duha.; Tajuddin, H.Anuar.; Abdullah, Z.; Ng, S.Weng., 2008: Quinoxalin-2-yl m-tolyl ether. The dihedral angle between the two aromatic ring systems in the title compound, C(15)H(12)N(2)O, is 79.4 (1)°. The angle at the O atom is widened to 116.93 (9)°.

Neef H., 1971: Supervision of blood coagulation of heart surgery. Medizinische Klinik 66(1): 16-21

Sidibé, E.Hassane., 2007: Reflections on mental retardation and congenital hypothyroidism: effects of trace mineral deficiencies. While deficiencies of trace minerals and vitamins are rare in humans eating a variety of food, they can occur in premature infants and those with disturbances in dietary behavior for physical or psychological reasons and during parenteral or enter...

Freund, H.; Yoshimura, N.; Fischer, J.E., 1980: Does intravenous fat spare nitrogen in the injured rat?. The role of glucose versus fat as a source of energy in parenteral nutrition is controversial, particularly when administered after trauma, injury or in sepsis. In the present series of experiments, rats undergoing laparotomy and jugular vein cann...

Abken, H.J.erg; Tietze, M.; Brodersen, J.; Bauemer, S.; Beifuss, U.; Deppenmeier, U., 1998: Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1. A hydrophobic, redox-active component with a molecular mass of 538 Da was isolated from lyophilized membranes of Methanosarcina mazei Go1 by extraction with isooctane. After purification on a high-performance liquid chromatography column, the chem...

Abdul Rahim, R.; Leong, L.C.; Chan, K.S.; Rahiman, M.H.; Pang, J.F., 2007: Real time mass flow rate measurement using multiple fan beam optical tomography. This paper presents the implementing multiple fan beam projection technique using optical fibre sensors for a tomography system. From the dynamic experiment of solid/gas flow using plastic beads in a gravity flow rig, the designed optical fibre se...

Saxena A.K.; Rewari R.B., 1990: Influence of zinc on nodulation and ion uptake by chickpea under saline conditions. Journal of the Indian Society of Soil Science 38(2): 363-364

Yingsukwattana, K.; Puttipipatkhachorn, S.; Ruktanonchai, U.; Sarisuta, N., 2015: Enhanced permeability across Caco-2 cell monolayers by specific mannosylating ligand of buserelin acetate proliposomes. Oral delivery of peptide and protein drugs still remains the area of challenges due to their low stability and permeability across GI tract. Among numerous attempts, the receptor-mediated drug targeting is a promising approach to enhance GI permea...

Kutuzova, G.I.; Polozov, R.I., 1995: An algorithm of specific site search in DNA primary structure. A simple method of revealing peculiarities in the nucleic acid primary structure. Efficiency comparison between the method suggested and that one based on the use of Kohonen neural network has also carried out.

Kayhan, N.; Bodem, J.P.; Vahl, C.F.; Hagl, S., 2002: The positive staircase and the Frank-Starling mechanism are altered in atrial myocardium of patients in end-stage heart failure transplanted for dilative cardiomyopathy. Transplantation Proceedings 34(6): 2185-2191, September