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Co-expression of PACAP with VIP, SP and CGRP in the porcine nodose ganglion sensory neurons

, : Co-expression of PACAP with VIP, SP and CGRP in the porcine nodose ganglion sensory neurons. Anatomia, Histologia, Embryologia 44(2): 86-91

Our previous study revealed the expression of substance P (SP) and calcitonin gene-related peptide (CGRP) in sensory distal ganglion of the vagus (nodose ganglion) neurons in the pig. As these neuropeptides may be involved in nociception, the goal of these investigations was to determine possible expression of vasoactive intestinal polypeptide (VIP), SP and CGRP in the pituitary adenylate cyclase-activating polypeptide-immunoreactive (PACAP-IR) porcine nodose perikarya. Co-expression of these substances was examined using a double-labelling immunofluorescence technique. To reveal the ganglionic cell bodies, the pan-neuronal marker protein gene product 9.5 (PGP 9.5) was used. Quantitative analysis of the neurons revealed that 67.25% of the PGP 9.5+ somata in the right-side ganglion and 66.5% in the left side, respectively, co-expressed PACAP-IR. Moreover, 60.6% of the PACAP-IR cells in the right-side ganglion and 62.1% in the left, respectively, co-expressed VIP. SP-IR was observed in 52.2 and 39.9% of the right and left ganglia, respectively. CGRP was found in 27.7 and 34.1% of the right and left distal ganglion of the vagus, respectively. High level of co-expression of PACAP with VIP, SP and CGRP in the distal ganglia of the vagus sensory perikarya directly implicates studied peptides in their functional interaction during nociceptive vagal transduction.


PMID: 24713103

DOI: 10.1111/ahe.12111

Other references

Epstein, J., 1986: Plasma adriamycin levels during remission induction therapy radioimmunoassay vs. high performance liquid chromatography. Plasma concentrations of adriamycin and adriamycinol were measured in patients with acute nonlymphocytic leukemia during remission induction therapy with araC adriamycin and cytosine arabinoside. Blood samples were analyzed at 10 min, 1,3,6 and 24...

Carpenter, R.L.; Newton, G.J.; Rothenberg, S.J.; Denee, P.B., 1980: Respirable aerosols from fluidized bed coal combustion 2. physical characteristics of fly ash. The respirable fraction of the exhaust aerosol produced by an experimental 18 in. atmospheric pressure fluidized bed coal combustor was sampled as part of a program to assess the potential inhalation hazard associated with this emerging technology...

Wu, C.H.; Powrie, W.D., 1995: Preservation of fresh fruit juices and fruit juice blends. Official Gazette of the United States Patent & Trademark Office Patents 1180(3): 1724, Nov 21

Summerfield, R.J.; Muehlbauer, F.J., 1982: Controlled environments as an adjunct to field research on lentils lens culinaris 2. research strategy. The strategy and associated practical details are described of a research program which seeks to make effective use of controlled environment facilities in providing information and screening techniques useful to lentil breeders. Two principal obj...

von Schweinitz, D.; Faundez, A.; Teichmann, B.; Birnbaum, T.; Koch, A.; Hecker, H.; Glüer, S.; Fuchs, J.; Pietsch, T., 2000: Hepatocyte growth-factor-scatter factor can stimulate post-operative tumor-cell proliferation in childhood hepatoblastoma. Rapid growth of residual tumor after partial hepatectomy has been observed during the period of liver regeneration in children with malignant embryonal hepatoblastoma. The aim of this study was to elucidate the role of hepatocyte growth-factor-sca...

Dolitskiy V.A.; Dolitskaya T.V., 1977: Gentle thrust fault in the Prorva area, western Kazakhstan. Transactions (Doklady) of the US

Crockett, M.E.; Deuel, H.J., 1947: A comparison of the coefficient of digestibility and the rate of absorption of several natural and artificial fats as influenced by melting point. The digestibility coefficients obtained were: margarine (m. p. 34[degree]C), 97.0%; Orisco (43[degree]C), 97.3%; prime steam lard (37[degree]C), 96.6%; bland lard (44[degree]C), 94.3%; hydrogenated lard (40 [degree]C), 63.2%; and hydrogenated lard...

Ercilla, M.G.; Arriaga, F.; Gratacós, M.R.; Coll, J.; Lecha, V.; Vives, J.; Castillo, R., 1981: HLA antigens and scleroderma. Archives of Dermatological Research 271(4): 381-385

Roiz, L.; Goren, R.; Shoseyov, O., 1995: Stigmatic RNase in calamondin (Citrus reticulata var. austera x Fortunella sp.). In plants of self-compatible calamondin, ribonuclease (RNase) activity was found in the stigmatic diffusate. Tissue print experiments using calamondin styles demonstrated that most of the RNase was localized in the stigma. Stigmatic RNase activity...

Stuber, Cw, 1992: Biochemical and molecular markers in plant breeding. Plant breeding reviews(9): 37-61