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Cocaine cues drive opposing context-dependent shifts in reward processing and emotional state


, : Cocaine cues drive opposing context-dependent shifts in reward processing and emotional state. Biological Psychiatry 69(11): 1067-1074

Prominent neurobiological theories of addiction posit a central role for aberrant mesolimbic dopamine release but disagree as to whether repeated drug experience blunts or enhances this system. Although drug withdrawal diminishes dopamine release, drug sensitization augments mesolimbic function, and both processes have been linked to drug seeking. One possibility is that the dopamine system can rapidly switch from dampened to enhanced release depending on the specific drug-predictive environment. To test this, we examined dopamine release when cues signaled delayed cocaine delivery versus imminent cocaine self-administration. Fast-scan cyclic voltammetry was used to examine real-time dopamine release while simultaneously monitoring behavioral indexes of aversion as rats experienced a sweet taste cue that predicted delayed cocaine availability and during self-administration. Furthermore, the impact of cues signaling delayed drug availability on intracranial self-stimulation, a broad measure of reward function, was assessed. We observed decreased mesolimbic dopamine concentrations, decreased reward sensitivity, and negative affect in response to the cocaine-predictive taste cue that signaled delayed cocaine availability. Importantly, dopamine concentration rapidly switched to elevated levels to cues signaling imminent cocaine delivery in the subsequent self-administration session. These findings show rapid, bivalent contextual control over brain reward processing, affect, and motivated behavior and have implications for mechanisms mediating substance abuse.

US$19.90

PMID: 21481843

DOI: 10.1016/j.biopsych.2011.02.014


Other references

Sen, A.; Heymann, J.Bernard.; Cheng, N.; Qiao, J.; Mindich, L.; Steven, A.C., 2008: Initial location of the RNA-dependent RNA polymerase in the bacteriophage Phi6 procapsid determined by cryo-electron microscopy. The RNA-dependent RNA polymerases (RdRPs) of Cystoviridae bacteriophages, like those of eukaryotic viruses of the Reoviridae, function inside the inner capsid shell in both replication and transcription. In bacteriophage Phi6, this inner shell is...

Lee, J.; Lee, U.; Kim, B.; Yoon, J., 2013: A computational method for detecting copy number variations using scale-space filtering. As next-generation sequencing technology made rapid and cost-effective sequencing available, the importance of computational approaches in finding and analyzing copy number variations (CNVs) has been amplified. Furthermore, most genome projects ne...

Stankiewicz, A.; Bakunowicz-Lazarczyk, A.; Grochowski, J.; Sobolewski, P., 1991: Function of the visual system after orbital surgery. Late observations. Forty six persons with an orbital tumor were operated in the period of 1980-1988. A control examination performed in 39 persons did not show in 38 any characteristics of recurrence of the tumor; the motility of the eye ball was normal. In 29 perso...

Kobayashi, H.; Sato, K.; Niioka, T.; Miura, H.; Ito, H.; Miura, M., 2016: Relationship Among Gefitinib Exposure, Polymorphisms of Its Metabolizing Enzymes and Transporters, and Side Effects in Japanese Patients With Non-Small-Cell Lung Cancer. The present study investigated the effects of patients' genetic variations in the pharmacokinetics of gefitinib at steady-state. We analyzed 31 Japanese patients with non-small-cell lung cancer (NSCLC) who had been treated with gefitinib. We...

Stephens, S.G., 1963: Polynesian cottons. The presence of species of Gossypium, which as a whole are widespread throughout the Pacific Islands, is interpreted as the result of at least three independent introductions, widely separated in time. It is suggested that the earliest introductio...

Friedler, R.M.; Koffler, A.; Kurokawa, K., 1977: Hyponatremia and hypernatremia. The concentration of serum sodium is determined by the external balance of water. Hyponatraemia occurs when total body water is in excess of Na; hypernatraemia develops when body water is relatively less in relation to Na. Both disorders may be pr...

O'reilly, M.; Lacey, C.; Lancioni, G., 2001: A preliminary investigation of the assessment and treatment of tantrums with two post-institutionalized Romanian adoptees. A functional analysis of tantrums was carried out with 2 children who were adopted from state-run Romanian orphanages. Tantrums included such behaviours as screaming, property destruction, self-injury and aggression. The functional analysis was co...

Llorens Cortes C.; Zini S.; Gros C.; Schwartz J C., 1991: Dopaminergic regulation of enkephalin release. The effects of dopamine receptor stimulation on enkephalin release in vitro and in vivo by measuring the changes in the levels of [Met5]enkephalin (YGGFM) and Tyr-Gly-Gly (YGG), a characteristic extracellular enkephalin metabolite produced under t...

Zhao, Y.; Lea, T.K.; Schotland, R.M., 1988: Correction function for the lidar equation and some techniques for incoherent CO(2) lidar data reduction. The convolution effect in CO(2) lidar return signals caused by the long laser pulse is analyzed by modifying the original lidar equation and introducing a correction function C(r)(R). The characteristics of C(r)(R) are discussed in detail, leading...

Jackson, S.M.; Whitworth, A.J.; Greene, J.C.; Libby, R.T.; Baccam, S.L.; Pallanck, L.J.; L.S.ada, A.R., 2005: A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage. CAG and CTG repeat expansions are the cause of at least a dozen inherited neurological disorders. In these so-called "dynamic mutation" diseases, the expanded repeats display dramatic genetic instability, changing in size when transmitte...