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Cognitive impairment and parkinsonism due to use of sodium valproate

, : Cognitive impairment and parkinsonism due to use of sodium valproate. Tijdschrift Voor Gerontologie en Geriatrie 40(1): 29-33

Two patients presented with progressive cognitive impairment and parkinsonism related symptoms while being treated with sodium valproate. Both patients suffered from progressive cognitive decline and mobility disorders with an insidious onset over a period of months to years. After discontinuation of sodium valproate both debilitating symptoms resolved nearly completely. There is a growing prevalence and incidence of epilepsy above the age of 60 and a great number of these patients are on sodium valproate treatment. All clinicians treating elderly patients should be aware of the fact that this treatment can cause reversible cognitive decline and parkinsonism probably due to impairment of mitochondrial complex I function. Discontinuation of sodium valproate is strongly recommended in all patients with development of cognitive impairment or parkinsonism or both during sodium valproate treatment.


PMID: 19326700

Other references

Joesten Raymond; Hill James; Van Horn Stephen R., 1994: Limestone assimilation and clinopyroxenite production along the contacts of a 9 metre alkali olivine basalt dike, Killala Bay, Ireland. Abstracts with Programs - Geological Society of America 26(7): 476

Sukhova, G.S.; Ignat'ev, D.A.; Akhremenko, A.K.; Levashova, V.G.; Mikhaleva, I.I.; Sviriaev, V.I.; Anufriev, A.I.; Ziganshin, R.Kh.; Kramarova, L.I.; Gnutov, D.Iu., 1990: The cardiotropic, hypometabolic and hypothermic activity of peptide fractions from the tissues of hibernating cold-adapted animals. From tissues of hibernating and active long-tailed ground squirrels and from the brain of cold-adapted Yakut horses, low molecular peptide fractions were obtained which, after injection to albino mice, decreased oxygen consumption and rectal tempe...

Borghgraef, C.; Repciuc, E., 1970: Ameloblastoma of gingival origin complicated by a secondary infection. Acta Stomatologica Belgica 67(4): 511-523

Mishra, Kc, 1982: Prevention and control of mycotoxicoses Animal feeds, human food, India. Indian farming 31(12): 11-13

Birch, L.; Elbrønd, O., 1985: Daily impedance audiometric screening of children in a day-care institution. Changes through one month. Fifty-seven children in a fairly new day-care institution were examined daily by impedance audiometry through 4 weeks. A Madsen Electronics ZS 330 tympanoscope was used. The tympanometric curves were divided into types A, C1, C2, and B, indicating...

Tanasijevic, D.; Sandic, M.; Pavicevic, N., 1951: Soil types in the region of Belgrade and Obrenovatz.. A soil map of the region on a 1: 150, 000 scale is appended. The soils include chernozem, degraded chernozem, brown earth (normal and podzolic), black aquatic soil, deluvial and skeletal soils.

Lim, T.K.; Chen, G.H.; McDonald, R.A.; Toews, G.B., 1996: Granulocyte-macrophage colony-stimulating factor overrides the immunosuppressive function of corticosteroids on rat pulmonary dendritic cells. Pulmonary dendritic cells (DC) are present in extremely small numbers, but they are the most potent antigen-presenting cells in the lungs. Pure populations of DC can be isolated from the lung following collagen digestion, Percoll gradient centrifu...

Takihara, Y.; Tkachuk, D.; Michalopoulos, E.; Champagne, E.; Reimann, J.; Minden, M.; Mak, T.W., 1988: Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus. In this paper we describe the genomic organization and sequence of the human T-cell receptor delta-chain diversity, joining, and constant genes. There is one delta-chain constant region gene (C delta) located approximately equal to 85 kilobases (k...

Young E.D.; Rice J.J.; Spirou G.A., 1990: Auditory nerve rate representation of sound localization information present in spectra generated by direction dependent pinna filtering. Society for Neuroscience Abstracts 16(1): 875

Gurney, J.H., 1879: Notes on a Catalogue of the Accipitres in the British Museum, by R. Bowdler Sharpe (1874). The discussion of the group Milvinae and the genera of Milvine affinities is continued. For the more important, see Rostrhamus, Machaer or hamphus, Henicopernis Falconidae .