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Cognitive symptoms are common in immune thrombocytopenia and associate with autonomic symptom burden

, : Cognitive symptoms are common in immune thrombocytopenia and associate with autonomic symptom burden. European Journal of Haematology 88(3): 224-228

People with adult immune thrombocytopenia (ITP) are commonly thought to have an isolated blood disorder, but many also describe memory and concentration problems. Cognitive impairment commonly associates with autonomic dysfunction. Here, we quantified cognitive symptoms in a large cohort of patients with ITP compared with controls and explored the relationship with autonomic symptoms. Patients with ITP were approached in the UK via the national ITP Support Association and invited to complete Composite Autonomic Symptom Scale (COMPASS; measure of autonomic symptoms) and Cognitive Failures Questionnaire (CFQ) together with one from a friend of similar age and sex without ITP. Three hundred and ninety-eight patients with ITP completed measures with paired data from a representative group of 189 patients and controls (47%). Both autonomic and cognitive symptom burden were higher in ITP compared with controls (COMPASS score (48 ± 14 vs. 38 ± 12; P > 0.0001); CFQ (43 ± 17 vs. 36 ± 13; P < 0.0001). A positive relationship was seen between increasing cognitive symptoms and higher COMPASS score (P < 0.0001; r(2) = 0.1). Increasing cognitive symptoms did not associate with platelet count (P = 0.08, r(2) = 0.008). Multivariate analysis confirmed age and COMPASS independently associated with higher CFQ but not platelet count. Immune thrombocytopenia is more than a bleeding disorder; cognitive symptoms are common and independently associate with autonomic symptoms but not disease severity.


PMID: 22044734

DOI: 10.1111/j.1600-0609.2011.01730.x

Other references

Wu, Y.X.; Yao, C.M.; Zheng, K.W., 1987: The relationship between grain development and light at varying plant densities. In field trials in 1982-83, rice cv. Shanyou No. 3 was grown at spacings of 16.7 cm in the rows and 20, 26.6 or 33 cm between rows to provide differing light conditions in the canopy. Tiller and ear numbers/unit area decreased as spacing increased...

Muthu, M.; Majumder, S.K.; Parpia, H.A.B., 1973: Detector for phosphine at permissible levels in air. A paper-strip detector has been developed for detecting maximum acceptable concentrations (0.05-0.3 p.p.m.) of phosphine in air. The strips are prepared by dipping them in a 1% solution of mercuric chloride in methyl yellow, and phosphine turns th...

Wu, D.; Wang, G., 1984: A new subspecies of Typhlomys cinereus Milne-Edwards from Yunnan, China. This paper deals with a new subspecies of T. cinereus collected from Yunnan during May-June, 1981. The type specimens are deposited at the Ecological Department of Kunming Branch, Academia Sinica Kunming. This species has 2 other subspecies T. c....

Walker, E.; Voisey, P., 1972: Comparison of sample preparation and mechanical measurement techniques for determination of the filling value of cut tobacco. Tobacco science: 6 78-81

Abushouk, A.Ibrahim.; Negida, A.; Ahmed, H., 2016: An updated review of Zika virus. NlmCategory="UNASSIGNED">The current outbreak of Zika virus (ZIKV) in South America is one of the most serious public health emergencies since the Ebola outbreak of West Africa [2014]. ZIKV belongs to the flaviviridae family and has t...

Singh R.N.; Saksena H.K., 1968: Bacterial blight disease of paddy m symptomatology xanthomonas oryzae. Plant Disease Reporter 52(8): 663-664

Mamutov, Z.; Kornienko, V.; Pivovarov, L., 1977: The role of algae in alkaline formation in rice cultivation. Povyshenie plodorodiia pochv risovykh polei: 93-203

Ou, J.; Glawdel, T.; Ren, C.L.; Pawliszyn, J., 2009: Fabrication of a hybrid PDMS/SU-8/quartz microfluidic chip for enhancing UV absorption whole-channel imaging detection sensitivity and application for isoelectric focusing of proteins. A poly(dimethylsiloxane)(PDMS)/SU-8/quartz hybrid chip was developed and applied in the isoelectric focusing (IEF) of proteins with ultraviolet (UV) absorbance-based whole-channel imaging detection (UV-WCID). Each hybrid chip was made of three lay...

Bruining G.J.; D.V.sser J.J., 1982: Home care system in the netherlands. Diabete & Metabolisme 8(2): 159

Misra, S.G.; Mani, D., 1992: Heavy metal contamination in the sewage-sludge of Mumfordganj, Allahabad. Total and DTPA-extractable heavy metal contents of sewage sludge of the Mumfordganj area of Allahabad (India) have been determined by Atomic Absorption Spectrophotometer. The analysis of samples collected from different sites revealed the presence...