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Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis


, : Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis. Arthritis Research & Therapy 10(6): R135-R135

Type II collagen is a DR4/DR1 restricted target of self-reactive T cells that sustain rheumatoid arthritis. The aim of the present study was to analyze the T-cell receptor repertoire at the onset of and at different phases in rheumatoid arthritis. We used the CDR3 BV-BJ spectratyping to study the response to human collagen peptide 261-273 in 12 patients with DR4+ rheumatoid arthritis (six at the onset of disease and six during the course of disease) and in five healthy DR4+ relatives. The collagen-specific T-cell repertoire is quite restricted at the onset of disease, involving approximately 10 rearrangements. Within the studied collagen-specific rearrangements, nearly 75% is shared among patients. Although the size of the repertoire used by control individuals is comparable to that of patients, it is characterized by different T-cell receptors. Part of the antigen-specific T-cell repertoire is spontaneously enriched in synovial fluid. The specific T-cell repertoire in the periphery was modulated by therapy and decreased with the remission of the disease. Failure of immunoscopy to detect this repertoire was not due to suppression of collagen-driven proliferation in vitro by CD4+ CD25+ T cells. Clinical relapse of the disease was associated with the appearance of the original collagen-specific T cells. The collagen-specific T-cell receptor repertoire in peripheral blood and synovial fluid is restricted to a limited number of rearrangements in rheumatoid arthritis. The majority of the repertoire is shared between patients with early rheumatoid arthritis and it is modulated by therapy.

US$19.90

PMID: 19014626

DOI: 10.1186/ar2553


Other references

Bao, X.; Sun, H.; Wong, N-Bew.; Gu, J., 2006: Microsolvation effect, hydrogen-bonding pattern, and electron affinity of the uracil-water complexes U-(H2O)n (n = 1, 2, 3). To achieve a systematic understanding of the influence of microsolvation on the electron accepting behaviors of nucleobases, the reliable theoretical method (B3LYP/DZP++) has been applied to a comprehensive conformational investigation on the urac...

Yu, P-Jiu.; Li, J-Rong.; Zhu, Z-Guang.; Kong, H-Yu.; Jin, H.; Zhang, J-Yan.; Tian, Y-Xin.; Li, Z-Huang.; Wu, X-Yun.; Zhang, J-Jie.; Wu, S-Guang., 2014: Praeruptorin D and E attenuate lipopolysaccharide/hydrochloric acid induced acute lung injury in mice. Acute lung injury is a life-threatening syndrome characterized by overwhelming lung inflammation and increased microvascular permeability, which causes a high mortality rate worldwide. The dry root of <italic>Peucedanum praeruptorum Dunn<...

Sudoh, M.; Sekiguchi, C.; Kurihara, S., 2001: Changes in body fluid distribution during 7 days 6 degrees head-down bed rest. It is well known that, in a state of weightlessness, body fluids shift toward the head site, but the actual rates of the migration of fluids has never been measured. In order to identify the causes of reduced orthostatic tolerance and the reductio...

Sugarbaker, P.H.; Leighton, S.B., 1986: Hepatic parenchymal suction dissector. A new instrument for hepatic parenchymal dissection has been developed. It is used to suction dissect tissue from around vessels and ducts to minimize blood loss during hepatic operations. The instrument is inexpensive, feels comfortable in the ha...

Anonymous, 1987: Dietary fibre and obesity. Proceedings of a symposium at 5th International Congress on Obesity. 16 September 1986, Jerusalem, Israel. International Journal of Obesity 11 Suppl 1: 1-108

Ingham, K.C.; Brew, S.A.; Migliorini, M., 1994: An unusual heparin-binding peptide from the carboxy-terminal hep-2 region of fibronectin. A synthetic 22 residue peptide, N22W, with sequence NVSPPRRARVTDATETTITISW, derived from the amino terminus of type III module 13 in the carboxy-terminal hep-2 domain of fibronectin, was found to exhibit unusual heparin binding properties. Titrati...

Hansen, O.; Seger, B.; Vesborg, P.C.K.; Chorkendorff, I., 2015: SOLAR FUELS. A quick look at how photoelectrodes work. Science 350(6264): 1030-1031

Horsman, M.R.; Overgaard, J.; Chaplin, D.J., 1988: The interaction between RSU-1069, hydralazine and hyperthermia in a C3H mammary carcinoma as assessed by tumour growth delay. Acta Oncologica 27(6b): 861-862

Burch, R.J.; Funk, E.C., 1959: Treatment of oroantral fistula: report of case. Journal of Oral Surgery, Anesthesia, and Hospital Dental Service 17: 58-60

Yang, Y.; Zhao, H.; Heath, A.C.; Madden, P.A.F.; Martin, N.G.; Nyholt, D.R., 2016: Shared Genetic Factors Underlie Migraine and Depression. Migraine frequently co-occurs with depression. Using a large sample of Australian twin pairs, we aimed to characterize the extent to which shared genetic factors underlie these two disorders. Migraine was classified using three diagnostic measures...