+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Combination of aripiprazole and other psychopharmacological treatments in resistant and multi-resistant patients

, : Combination of aripiprazole and other psychopharmacological treatments in resistant and multi-resistant patients. Current Drug Safety 3(3): 210-215

Aripiprazole is a new antipsychotic agent that has proven safe and efficacious in controlled clinical trials. However, few published data on its effectiveness and safety when used in augmentation and combination are available. Our study aimed to determine the functional effectiveness and safety of different combinations of aripiprazole with other psychotropics in resistant patients. All acute not selected (15) patients treated with aripiprazole and other psychotropics between February 2005 and May 2007 are included. Mean follow-up 20.4 days. Main diagnosis was schizophrenia (40%) and mean dose of aripiprazole was 25 mg/d. Resistant patients received initially multiple psychotropics (mean 3.3) and their functional status was very low. A significant functional improvement was observed after admission in most (12) of them. Only three patients experienced mild to moderate improvement; another three patients showed extrapyramidal symptoms. No dermatological reactions or adverse effects were observed with lamotrigine association. DISCUSIONS: The combination of aripiprazole with other psychotropics was well tolerated. No significant new adverse reactions were observed. In a short term follow-up, our results show a good tolerability of aripiprazole in combination with other psychotropics of different groups.


PMID: 18691004

Other references

Trzepacz, P.T., 1987: Concurrent narcolepsy and bipolar affective disorder. Psychosomatics 28(4): 219-221

Wu, A.H.B., 2003: The ischemia-modified albumin biomarker for myocardial ischemia. Ischemia-modified albumin is the first biomarker for myocardial ischemia to be approved by the FDA. Other markers are being evaluated such as free fatty acids, pregnancy-associated plasma protein-A, glycogen phosphorylase isoenzyme BB, sphingosine...

McEvers, A.E., 1935: Concerning article in February issue. California and Western Medicine 42(3): 227-227

Misgeld, V., 1971: Adiponecrosis subcutanea neonatorum--sclerema neonatorum--Buschke's scleredema. Nosography with reference to the literature since 1950. Archiv für Kinderheilkunde 183(1): 5-22

Fuentes, M.B.; Goel, R.; Lee-Ong, A.C.; Cabrera, E.B.; Lawenko, M.; Lopez-Gutierrez, J.; Lomanto, D., 2013: Single-port endo-laparoscopic surgery (SPES) for totally extraperitoneal inguinal hernia: a critical appraisal of the chopstick repair. Developments in minimal access surgery brought a new concept: single-port endolaparoscopic surgery (SPES). The aim of our study is to verify the safety and feasibility of SPES TEP hernia repair and report our initial clinical outcome. We prospecti...

Paredes Suarez M.; Varea Teran J., 1974: Radio immunoassay of human thyrotropin materno fetal relation at high altitude. Ericson, Anne (Ed ) Radioimmunoassay And Related Procedures in Medicine, Vol 1 Proceedings Of A Symposium Istanbul, Turkey, Sept 10-14, 1973 469p Illus International Atomic Agency: Vienna, Austria (Dist in U S By Unipub, Inc , New York, N Y ) 221-235

Ovnatanyan, K.T., 1959: Perforation of the intestinal tract by Ascaris.. Ovnatanyan considers the different pathological conditions which may lead to intestinal perforation by Ascaris. He describes a case in which Ascaris perforated healthy intestine. G. I. Pozniak.

Yang, Z-xu.; Luan, G-ming.; Yan, L.; Zhang, Y., 2004: Establishment of temporal epilepsy models and its permanent epilepsy sensitivity. To explore a better method to establish an animal model of temporal epilepsy in rat and study the pathological basis of permanent epilepsy sensitivity. Kainic acid (KA) with the dosage calculated according to the body weight was injected into 30 W...

Macintyre, U.; Glatthaar, I.; Elias, J.W.lker, A., 1998: Nutritional risk factors for coronary heart disease in South African medical students. The African population in South Africa is undergoing relatively rapid transition in lifestyle, with increasing proneness to western diseases. At the Medical University of Southern Africa (MEDUNSA), the majority of the African students come from ho...

Xie, P.; Jiang, X-Y.; Bu, Z.; Fu, S-Y.; Zhang, S-Y.; Tang, Q-P., 2016: Free choice feeding of whole grains in meat-type pigeons: 1. effect on performance, carcass traits and organ development. NlmCategory="UNASSIGNED">The effects of 5 different feeding systems on the performance, carcass traits and organ development were studied in pigeon squabs. The 5 treatments were (1) whole grains of maize, pea and wheat plus concentrat...