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Commentaries on the current treatment of selected neurologic diseases

, : Commentaries on the current treatment of selected neurologic diseases. Clinical Therapeutics 35(10): 1478-1479


PMID: 24139419

DOI: 10.1016/j.clinthera.2013.09.007

Other references

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Jean, P.; Lopez-Garcia, P.; Dansette, P.; Mansuy, D.; Goldstein, J., L., 1996: Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9. Oxidation of tienilic acid by human cytochromes P-450 (CYP) 2C9, 2C18, 2C8 and 2C19 was studied using recombinant enzymes expressed in yeast. CYP 2C9 was the best catalyst for 5-hydroxylation of tienilic acid (K(m) = 5 +/- 1 microM, kcat = 1.7 +/-...