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Comparative efficacy of extracts from Lycium barbarum bark and fruit on estrogen receptor positive human mammary carcinoma MCF-7 cells


, : Comparative efficacy of extracts from Lycium barbarum bark and fruit on estrogen receptor positive human mammary carcinoma MCF-7 cells. Nutrition and Cancer 66(2): 278-284

Chemo-endocrine therapy for estrogen receptor positive (ER(+)) breast cancer exhibits acquired tumor resistance. Herbal medicines provide integrative support for breast cancer patients. Present study compared the efficacy of aqueous extracts from Lycium barbarum bark (LBB) and Lycium barbarum fruit (LBF) on ER(+) MCF-7 cells. Cellular growth and 17ß-estradiol (E2) metabolism quantified the efficacy. MCF-7 cells maintained in serum depleted medium+ E2 exhibited increased anchorage-dependent and anchorage-independent growth. LBB exhibited greater potency than LBF (95% reduction in IC50). LBB produced a 6.8-fold increase, 40% decrease, and a 3.7-fold increase in 2-hydroxyestrone (2-OHE1), 16α-hydroxyestrone (16α-OHE1), and estriol (E3) formation. The corresponding values for LBF were 3.9, 33, and 10.5. LBB produced a16.3-fold and a twofold increase in 2-OHE1:16α-OHE1 and E3:16α-OHE1 ratios, whereas LBF produced a sixfold and a 2.9-fold increase. The efficacy of LBB is due to increased 2-OHE1 formation, whereas that of LBF is due to accelerated conversion of 16α-OHE1 to E3. Specific growth inhibitory profiles of LBB and LBF may be due to their distinct chemical composition and their complementary actions on E2 metabolism. This study validates a mechanistic approach to identify efficacious herbal extracts for clinical ER(+) breast cancer.

US$19.90

PMID: 24377707

DOI: 10.1080/01635581.2014.864776


Other references

Kramer, A.I., 1957: Winter wheat varieties valuable for the Stavropol' territory.. Odessa 3 and Odessa 16, both from the Institute of Breeding and Genetics, outyielded Voro-silovskaja in the steppe districts, Odessa 16, in addition, possessing better baking and milling properties and showing improved resistance to Puccinia. Bezo...

Afanas yev L.M.; Braun K.N., 1976: Petrochemical characteristics of Mesozoic granitoids of the southern part of western Transbaikalia. Pages 123-137:

Tahir, M.; Vasilopoulos, P., 2015: Electrically tunable magnetoplasmons in a monolayer of silicene or germanene. We theoretically study electrically tunable magnetoplasmons in a monolayer of silicene or germanene. We derive the dynamical response function and take into account the effects of strong spin-orbit coupling (SOC) and of an external electric filed...

Gaydess, A.; Duysen, E.; Li, Y.; Gilman, V.; Kabanov, A.; Lockridge, O.; Bronich, T., 2010: Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system. Butyrylcholinesterase (BChE) is an efficient bioscavenger of highly toxic organophosphorus poisons and nerve agents. However, BChE administered into the periphery does not provide significant protection of the central nervous system (CNS) due to r...

Zorreguieta, A.; Ugalde, R.A., 1986: Formation in Rhizobium and Agrobacterium spp. of a 235-kilodalton protein intermediate in beta-D(1-2) glucan synthesis. beta-D(1-2) Glucan was synthesized by Agrobacterium and Rhizobium spp. in vitro with enzymes from the internal membranes upon the addition of UDF glucose and Mg2+ or Mn2+. An intermediate containing protein and beta-D(1-2) glucan was formed during...

Montes de Oca, N.V.; Cabrera Alonso, C.; Martínez, R.; Cantelar de Francisco, N.; Pérez Insueta, O., 1989: Serologic study of the diagnosis of Chagas disease in Nicaraguan students in the Juventud island. The results obtained during the serologic study for the diagnosis of Chagas' disease in 868 Nicaraguan students in the Isle of Youth are reported. Qualitative hemagglutination and indirect immunofluorescence were used. It was found that 8.5%...

Erdman, G., 1971: Beobachtungen am nest der Ringeltaube. Falke: 165-167

Wasowicz, K.; Majewski, M.; Lakomy, M., 1998: Distribution of neurons innervating the uterus of the pig. The distribution of neurons innervating the uterus of the pig was studied with the use of fluorescent retrograde tracer Fast Blue. Tracer injections were made into the uterine cervix, pericervical, middle and perioviductal part of the right uterin...

Van-Walraven, H.S.; Marvin, H.J.P.; Koppenaal, E.; Kraayenhof, R., 1984: Proton movements and electric potential generation in reconstituted atpase ec 3.6.1.3 proteoliposomes from the thermophilic cyanobacterium synechococcus 6716. ATP hydrolysis-induced proton translocation and electric potential generation were studied in ATPase proteoliposomes by means of various optical probes. The proteoliposomes consisted of reconstituted ATPase complex and native lipid mixture isolate...

Kennedy, A., 2000: Parafoveal processing in word recognition. Two experiments investigated the degree to which properties of a word presented in the parafovea influenced the time to process a word undergoing concurrent foveal inspection. In Experiment 1, subjects viewed a set of five-letter words at a fixed...