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Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala


, : Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala. Influenza and Other Respiratory Viruses 8(4): 414-421

Human metapneumovirus (HMPV) is an important cause of acute respiratory infections (ARI), but little is known about how it compares with respiratory syncytial virus (RSV) in Central America. In this study, we describe hospitalized cases of HMPV- and RSV-ARI in Guatemala. We conducted surveillance at three hospitals (November 2007-December 2012) and tested nasopharyngeal and oropharyngeal swab specimens for HMPV and RSV using real-time reverse transcription-polymerase chain reaction. We calculated incidence rates, and compared the epidemiology and outcomes of HMPV-positive versus RSV-positive and RSV-HMPV-negative cases. We enrolled and tested specimens from 6288 ARI cases; 596 (9%) were HMPV-positive and 1485 (24%) were RSV-positive. We observed a seasonal pattern of RSV but not HMPV. The proportion HMPV-positive was low (3%) and RSV-positive high (41%) for age <1 month, whereas these proportions were similar (~20%) by age 2 years. The annual incidence of hospitalized HMPV-ARI was 102/100 000 children aged <5 years [95% confidence interval (CI): 75-178], 2.6/100 000 persons aged 5-17 years (95%CI: 1.2-5.0), and 2.6/100 000 persons aged ≥ 18 years (95%CI: 1.5-4.9). Among children aged <5 years, HMPV-positive cases were less severe than HMPV-RSV-negative cases after adjustment for confounders [odds ratio (OR) for intensive care = 0.63, 95% CI 0.47-0.84]; OR for death = 0.46, 95% CI 0.23-0.92). Human metapneumovirus is a substantial contributor to ARI hospitalization in Guatemala, but HMPV hospitalizations are less frequent than RSV and, in young children, less severe than other etiologies. Preventive interventions should take into account the wide variation in incidence by age and unpredictable timing of incidence peaks.

US$19.90

PMID: 24761765

DOI: 10.1111/irv.12251


Other references

Pigula F.A.; Leavitt B.J.; Bell S.P.; Slinker B.K.; Mulieri L.A.; Leavitt M., 1992: 23 3 butanedione monoxime bdm provides effective biochemical and mechanical preservation in the ischemic dog heart. Journal of Molecular & Cellular Cardiology 24(SUPPL 3): S9

Szepesi D.J., 1978: Transmission of sulfur di oxide on local regional and continental scale. Atmospheric Environment 12(1-3): 529-535

Khavkina, N.N.; Kopeĭkin, G.A., 1967: Electromyographic characteristics of the phenomenon of increased work capacity in fatigue during the application of various strengths of proprioceptive stimulation. Nervnaia Sistema 8: 123-127

Suskovic, S.; Pohl, W.; Turel, M.; Kohn, H.; Kummer, F.; Kosnik, M.; Sorli, J., 1994: Circadian rhythms of eosinophil cationic protein in asthmatics treated betamimetics, methylprednisolone or cyclosporine. European Respiratory Journal 7(SUPPL 18): 262S

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Adams, E.Kathleen.; Nishimura, B.; Merritt, R.K.; Melvin, C., 2003: Costs of poor birth outcomes among privately insured. Despite expansions in the public insurance coverage of pregnant women, concerns over poor birth outcomes remain. Poor birth outcomes occur among publicly and privately insured women, however, thereby imposing excess costs on employers and their in...

Royal College O.Physicians, 1999: Maintaining good medical practice: Clinical governance and self regulation for physicians. A high standard of medical practice is a prerequisite of good medical care and clinical governance is the means for ensuring that a high standard is maintained. In February of this year the College issued the following report to its Fellows and Me...

Costa, M.A.L. da; Ortega Flores, C.I.; Penteado, M. de V.C., 2001: Interaction between the 9-cis, 13-cis and all-trans beta -carotene isomers on their bioconversion into vitamin A. With the objective of verifying the importance of the interaction between the 9-cis, 13-cis and all-trans beta -carotene isomers on their bioconversion into vitamin A, an assay based on the hepatic depletion of vitamin A reserves model in rats was...