+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Comparison of healthcare utilization among patients treated with alcoholism medications

, : Comparison of healthcare utilization among patients treated with alcoholism medications. American Journal of Managed Care 16(12): 879-888

To determine in a large claims database the healthcare utilization and costs associated with treatment of alcohol dependence with medications vs no medication and across 4 US Food and Drug Administration (FDA)-approved medications. Claims database analysis. Eligible adults with alcohol dependence claims (n = 27,135) were identified in a commercial database (MarketScan; Thomson Reuters Inc, Chicago, Illinois). Following propensity score-based matching and inverse probability weighting on demographic, clinical, and healthcare utilization variables, patients who had used an FDA-approved medication for alcohol dependence (n = 2977)were compared with patients who had not (n =2977). Patients treated with oral naltrexone hydrochloride(n = 2064), oral disulfiram (n = 2076), oral acamprosate calcium (n = 5068), or extended-release injectable naltrexone (naltrexone XR) (n = 295) were also compared for 6-month utilization rates of alcoholism medication, inpatient detoxification days, alcoholism-related inpatient days, and outpatient services, as well as inpatient charges. Patients who received alcoholism medications had fewer inpatient detoxification days (706 vs 1163 days per 1000 patients, P <.001), alcoholism-related inpatient days (650 vs 1086 days, P <.001), and alcoholism-related emergency department visits (127 vs 171, P = .005). Among 4 medications, the use of naltrexone XR was associated with fewer inpatient detoxification days (224 days per 1000 patients) than the use of oral naltrexone (552 days, P = .001), disulfiram (403 days, P = .049), or acamprosate (525 days, P <.001). The group receiving naltrexone XR also had fewer alcoholism-related inpatient days than the groups receiving disulfiram or acamprosate. More patients in the naltrexone XR group had an outpatient substance abuse visit compared with patients in the oral alcoholism medication groups. Patients who received an alcoholism medication had lower healthcare utilization than patients who did not. Naltrexone XR showed an advantage over oral medications in healthcare utilization and costs.


PMID: 21348558

Other references

Zoz, N.N.; Kolotenkov, P.V.; Makarova, S.I., 1964: Mutations in the pea, induced by ethylenimine and its derivatives. Ethylenimine, ethyleniminepiperidine, and N-beta-bis (ethyleniminomethyl) amino-ethylethylenimine manifested an approximately identical mutagenic activity when they acted on seeds of the Pobeditel[image] G-33-2, Neistosh-chimyi G-0195, and Supovay...

Gemmell, E.; Grieco, D.A.; Seymour, G.J., 2001: Chemokine expression in Porphyromonas gingivalis-specific T-cell lines. Autologous non-T cells (monocytes and B cells) were added to Porphyromonas gingivalis-specific T cell lines established from 9 healthy adults together with P. gingivalis outer membrane antigens for 4-6, 16-18, 24 and 48 h. Flow cytometry was emplo...

Hendrich, K.S.; Kochanek, P.M.; Melick, J.A.; Schiding, J.K.; Statler, K.D.; Williams, D.S.; Marion, D.W.; Ho, C., 2001: Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI. The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin-labeled MRI in rats anesthetized with either an opiate (fentanyl), a potent inhalation anesthetic agent (isoflurane), o...

Moritoki H.; Shinohara Y.; Yamauchi M.; Ishida Y., 1972: Potentiating effect of choline on the action of phenyl acetate 12th report formation of phenyl acetate and choline by intestinal homogenates. Folia Pharmacol Jap 68(3): 103p

Rademaker, M., 1994: Allergic contact dermatitis from lavender fragrance in Difflam gel. Contact Dermatitis 31(1): 58-59

Giachi, L.M.; Lanfranchi, R., 1967: Surgical technics in the treatment of scoliosis. Minerva Ortopedica 18(3): 169-177

Bhattacharya, A.N.; Marks, B.H., 1969: Reserpine induced and chlorpromazine metab induced changes in hypothalamo hypophyseal adrenal system in rats in the presence and absence of hypo thermia reserpine metab. Journal of Pharmacology and Experimental Therapeutics 165(1): 108-116

Rachkus-Yu, A.; Lebenka, A.Y. ; Kanopkaite, S.I., 1978: Methylation of high molecular weight rna. Incorporation of methyl groups of methionine into high-MW, primarily ribosomal RNA extracted from hepatic cells of healthy rats, tumor-bearing rats and from Zajdela ascites hepatoma cells was studied. Two i.p. doses 4 h apart of L-[methyl-14C]meth...

Tamura, S-ichi.; Hasegawa, H.; Kurata, T., 2010: Estimation of the effective doses of nasal-inactivated influenza vaccine in humans from mouse-model experiments. Mouse models of influenza play an important role in developing effective human influenza vaccines. We have demonstrated that intranasal immunization with inactivated subvirion (SV) vaccines, in conjunction with a cholera toxin B subunit adjuvant (...

Murasecco Suardi P.; Gassmann E.; Braun A.M.; Oliveros E., 1987: Determination of the quantum yield of intersystem crossing of rose bengal. The quantum yield of intersystem crossing ( of a sensitizer is related to the quantum yield of singlet-oxygen production (.vphi.(1O2)) by the efficiency of the energy transfer ( and is an important parameter in the evaluation of...