+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Comparison of therapeutic results from radiofrequency ablation and stereotactic body radiotherapy in solitary lung tumors measuring 5 cm or smaller

, : Comparison of therapeutic results from radiofrequency ablation and stereotactic body radiotherapy in solitary lung tumors measuring 5 cm or smaller. International Journal of Clinical Oncology 20(3): 499-507

This retrospective study was conducted to compare the clinical outcomes of radiofrequency ablation (RFA) with those of stereotactic body radiotherapy (SBRT) in patients with lung tumors. Local tumor progression, adverse events, and overall survival were compared in patients who underwent either RFA or SBRT for a single lung tumor measuring 5 cm or smaller. This study was approved by the institutional review boards of two institutions. Informed consent was waived. During September 2009 to June 2012, 48 patients [30 males and 18 females, with a mean age ± standard deviation (SD) of 75.0 ± 7.5 years] underwent RFA at one institution and 47 patients (21 males and 26 females, with a mean age ± SD of 77.0 ± 7.5 years) underwent SBRT in another. The mean maximum tumor diameter ± SD was 2.0 ± 0.8 cm (range 0.6-3.9 cm) in the RFA group, and 2.1 ± 0.9 cm (range 0.8-4.7 cm, p = 0.539) in the SBRT group. The RFA and SBRT groups showed similar 3-year local tumor progression [9.6%, 95% confidence interval (CI) 3.6-23.9% vs. 7.0%, 95% CI 0.2-20.2%, p = 0.746] and overall survival rates (86.4%, 95% CI 69.2-94.3% vs. 79.6%, 95% CI 60.6-90.1%, p = 0.738). No factor significantly affected local tumor progression. A maximum tumor size of 2 cm was identified as a prognostic factor in both univariate and multivariate analyses. No death was related to treatment procedures. Major complication rates (Grade 3 adverse events) of the RFA (10.4%, 5/48) and SBRT (8.5%, 4/47, p > 0.999) groups were similar. For lung tumor patients, lung RFA provided local tumor control and survival that were similar to those achieved using SBRT, with equal safety.


PMID: 25130494

DOI: 10.1007/s10147-014-0741-z

Other references

Kreuzer H.; Pozaryska K., 1982: NDS 247; Palaeocene, K-Ar/ glaucony, NW European basins. Pages 933 1982

Eaves, C.A., 1953: Storage quality of Cortland apples as influenced by tree nutrition. Results show that acid loss in Cortland apples was associated with the application of P and N, and that K served to offset this effect. - Kentville Exp.

Saravanan, V.; Kelly, C.A., 2003: Reducing the risk of methotrexate pneumonitis in rheumatoid arthritis. beta-globin mRNA bearing a nonsense codon is degraded in the cytoplasm of erythroid cells by endonuclease cleavage, preferentially at UG dinucleotides. An endonuclease activity in polysomes of MEL cells cleaved beta-globin and albumin mRNA in vitr...

Milkowitz, K.; Hesse, L.; Kroll, P., 1996: Intravitreally injected tissue plasminogen activator does not induce intraocular hemorrhage in diabetics with proliferative diabetic vitreoretinopathy. Investigative Ophthalmology & Visual Science 37(3): S977

Loose-Wagenbach, I.; Schmitt-Bylandt, T., 1987: Experience evaluating the uniformity of roentgen equipment. Rontgenpraxis; Zeitschrift für Radiologische Technik 40(2): 51-56

DeSelm, H.R.; Wofford, B.E.; Kral, R.; Chester, E.W., 1994: An annotated list of grasses (Poaceae, Gramineae) of Tennessee. A list of 339 native and introduced Tennessee grass taxa is given. The list was compiled from herbaria records and appropriate literature. Extraneous and intraneous floristic elements are identified and their distribution patterns are discussed an...

Ohe, K.; Yoshida, M.; Nakano-Kobayashi, A.; Hosokawa, M.; Sako, Y.; Sakuma, M.; Okuno, Y.; Usui, T.; Ninomiya, K.; Nojima, T.; Kataoka, N.; Hagiwara, M., 2017: RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the iIKBKAP gene of familial dysautonomia. The 5' splice site mutation (IVS20+6T>C) of the <i>inhibitor of κ light polypeptide gene enhancer in B cells, kinase complex-associated protein</i> (<i>IKBKAP</i>) gene in familial dysautonomia (FD) is at the sixth...

Ishiyama, N.; Oga, Y.; Hisataka, J.; Nagamine, C.; Mori, Y., 1979: Nursing plans aimed at problem solving--practice in the past 5 years since the introduction of POS. Kango Tenbo. Japanese Journal of Nursing Science 4(8): 685-693

Funk, D.T., 1970: Genetics of Black Walnut. A review discussing the taxonomy, evolution and natural distribution of Juglans spp., and describing flowering and fruiting, seed treatment and nursery practice, vegetative propagation, and genetics and breeding in J. nigra. Improvement programmes...

Adelson C.E., 1969: Lake manyas turkey a turkish park for birds sanctuary. National Parks Magazine 43(259): 25-27