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Comprehensive population-averaged arterial input function for dynamic contrast-enhanced vmagnetic resonance imaging of head and neck cancer


, : Comprehensive population-averaged arterial input function for dynamic contrast-enhanced vmagnetic resonance imaging of head and neck cancer. International Journal of Radiation Oncology, Biology, Physics 89(3): 658-665

To generate a population-averaged arterial input function (PA-AIF) for quantitative analysis of dynamic contrast-enhanced MRI data in head and neck cancer patients. Twenty patients underwent dynamic contrast-enhanced MRI during concurrent chemoradiation therapy. Imaging consisted of 2 baseline scans 1 week apart (B1/B2) and 1 scan after 1 week of chemoradiation therapy (Wk1). Regions of interest (ROIs) in the right and left carotid arteries were drawn on coronal images. Plasma concentration curves of all ROIs were averaged and fit to a biexponential decay function to obtain the final PA-AIF (AvgAll). Right-sided and left-sided ROI plasma concentration curves were averaged separately to obtain side-specific AIFs (AvgRight/AvgLeft). Regions of interest were divided by time point to obtain time-point-specific AIFs (AvgB1/AvgB2/AvgWk1). The vascular transfer constant (Ktrans) and the fractional extravascular, extracellular space volume (Ve) for primaries and nodes were calculated using the AvgAll AIF, the appropriate side-specific AIF, and the appropriate time-point-specific AIF. Median Ktrans and Ve values derived from AvgAll were compared with those obtained from the side-specific and time-point-specific AIFs. The effect of using individual AIFs was also investigated. The plasma parameters for AvgAll were a1,2 = 27.11/17.65 kg/L, m1,2 = 11.75/0.21 min(-1). The coefficients of repeatability (CRs) for AvgAll versus AvgLeft were 0.04 min(-1) for Ktrans and 0.02 for Ve. For AvgAll versus AvgRight, the CRs were 0.08 min(-1) for Ktrans and 0.02 for Ve. When AvgAll was compared with AvgB1/AvgB2/AvgWk1, the CRs were slightly higher: 0.32/0.19/0.78 min(-1), respectively, for Ktrans; and 0.07/0.08/0.09 for Ve. Use of a PA-AIF was not significantly different from use of individual AIFs. A PA-AIF for head and neck cancer was generated that accounts for differences in right carotid artery versus left carotid artery, day-to-day fluctuations, and early treatment-induced changes. The small CRs obtained for Ktrans and Ve indicate that side-specific AIFs are not necessary. However, a time-point-specific AIF may improve pharmacokinetic accuracy.

US$19.90

PMID: 24929169

DOI: 10.1016/j.ijrobp.2014.03.006


Other references

Hasanzadeh Mofrad, M.; Shafiei, R.; Bolandi, S.; Najjari, M.; Hatam, G.R., 2012: Leech bite: a rare cause of postmenopausal vaginal bleeding. Iranian Red Crescent Medical Journal 14(6): 384-385

Hirschowitz B.; Gibson R., 1976: Effect of cimetidine a new histamine 2 antagonist on canine gastric secretion. Federation Proceedings 35(3): 539

Anonymous, 1997: Is herbicide tolerance the way forward?. The prospects for herbicide-tolerant crops in Europe are assessed. Aspects of concern to the public are discussed, including safety and environmental issues, and a perceived increased reliance on agrochemical usage. In contrast, the agrochemical i...

Ilyin, V.N., 2007: Current strategy of neonatal cardiology. The state of the art of cardiosurgical care to neonatal infants with heart diseases is analyzed. The efficiency of first aid to the newborn with critical congenital heart diseases, the basic approaches to surgically correcting the most common seve...

Bounds, C.E.; Kwilas, S.A.; Kuehne, A.I.; Brannan, J.M.; Bakken, R.R.; Dye, J.M.; Hooper, J.W.; Dupuy, L.C.; Ellefsen, B.; Hannaman, D.; Wu, H.; Jiao, J-an.; Sullivan, E.J.; Schmaljohn, C.S., 2016: Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses. DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and Sudan virus (SUDV) produce fully human polyclonal antibodies (pAbs) that recognize both viru...

Jessup, D.A., 2007: Wildlife oil spill response for veterinarians. Small animal and exotics Proceedings of the North American Veterinary Conference, Volume 21, Orlando, Florida, USA, 2007: 1690-1692

Borelli, T.; Kassman, A., 1996: Meeting standards. Science 274(5295): 1995-1995

Anonymous, 2002: Some sections of the Public Health Act concern nurses. Lawmakers have taken some of the OIIQ's recommendations into account. L'infirmiere du Quebec 9(5 Suppl): 5-5

Li, D.; Yang, B.; Mehta, J.L., 1998: Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas. Oxidized low-density lipoprotein (ox-LDL) plays a critical role in the development of atherosclerosis. Recent studies show that ox-LDL may induce apoptosis of cultured rabbit smooth muscle cells and human macrophages. This study was designed to de...

Ozek, M., 1958: Use of sociometry in clinical psychotherapy. Zeitschrift für Psychotherapie und Medizinische Psychologie 8(5): 180-184