geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level


, : Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology 123(1): 79-89

CD4+ CD25(high) regulatory T cells (Tregs) of patients with relapsing-remitting (RR) multiple sclerosis (MS), in contrast to those of patients with secondary progressive (SP) MS, show a reduced suppressive function. In this study, we analysed forkhead box P3 (FOXP3) at the single-cell level in MS patients and controls (healthy individuals and patients with other neurological diseases) by means of intracellular flow cytometry. Our data revealed a reduced number of peripheral blood CD4+ CD25(high) FOXP3+ T cells and lower FOXP3 protein expression per cell in RR-MS patients than in SP-MS patients and control individuals, which was correlated with the suppressive capacity of Tregs in these patients. Interestingly, interferon (IFN)-beta-treated RR-MS patients showed restored numbers of FOXP3+ Tregs. Furthermore, a higher percentage of CD4+ CD25(high) FOXP3+ Tregs in RR-MS patients, as compared with controls and SP-MS patients, expressed CD103 and CD49d, adhesion molecules involved in T-cell recruitment towards inflamed tissues. This was consistent with a significantly increased number of CD27+ CD25(high) CD4+ T cells in the cerebrospinal fluid (CSF), as compared with peripheral blood, in RR-MS patients. Taken together, these data show aberrant FOXP3 expression at the single-cell level correlated with Treg dysfunction in RR-MS patients. Our results also suggest that Tregs accumulate in the CSF of RR-MS patients, in an attempt to down-regulate local inflammation in the central nervous system.

US$19.90

PMID: 17897326

DOI: 10.1111/j.1365-2567.2007.02690.x


Other references

Donatelli, L.; Benelli, R., 1946: Variations of some organs of growing guinea-pigs treated with folliculine. Guinea-pigs were weaned on the 15th day of life, gonadectomized on the 20th day, and the given 0.25 mg. of estradiol benzoate twice a wk. from the 28th to the 90th day of life. The animals and untreated controls were killed on the 95th day. The fo...

Dorrucci, M.; Iacobelli, S.; Suligoi, B.; Pezzotti, P.; Sinicco, A.; Angarano, G.; Tinari, N.; Rezza, G., 2004: Longitudinal analysis of the 90K glycoprotein in the Italian HIV-seroconversion study: temporal trend and predictability of the maturity of HIV infection. Objectives. To evaluate the level of 90K as a predictor of AIDS; to describe 90K levels over time after HIV serconversion; and to evaluate the 90K level as a marker of the maturity of infection. Design. Prospective incident cohort of HIV-infected...

Fairchild, M., 1994: Focus on Michele Fairchild. Hospital Food & Nutrition Focus 11(2): 7-8

Kim, D-Soo.; Kang, S-Gu.; Yoo, D-Sung.; Huh, P-Woo.; Cho, K-Souk.; Park, C.Kun., 2011: Ruptured right posterior inferior cerebellar artery aneurysm associated with hypoplasia of the right vertebral artery and both internal carotid arteries. The authors report an extremely rare case of a ruptured saccular aneurysm of the right posterior inferior cerebellar artery (PICA) associated with hypoplasia of bilateral internal carotid arteries (ICAs) and the right vertebral artery (VA). The an...

Elias Saion; Wood, A.K.H.; Zainal Abidin Sulaiman; Alzahrany, A.A.; M.S.haimi Elias; Wee BoonSiong, 2007: Determination of heavy metal pollution in depth profile of marine sediment samples from the Strait of Malacca. In this study, four core marine sediment samples from the Strait of Malacca were collected and analysed by using instrumental neutron activation analysis (INAA). This work was carried out to evaluate the level of heavy metal pollution in the water...

Muller, B.; Meley, J.; Bouteille, H.; Meyrieux, A., 1952: Two cases of grave hemorrhagic rectocolitis treated with cortisone and then by total colectomy. Archives des Maladies de L'appareil Digestif et des Maladies de la Nutrition 41(12): 1269-1276

Mandal J., 1986: Palynological study of Sutunga coal seam, Jaintia Hills, Meghalaya, India. The Palaeobotanist 35(2): 196-199

Andrés, R.Carranza.Camilo.; Helena, B.Cruz.Rosa.; Juliana, P.Pinzón.Carmen.; Viviana, A.Marquez.Yeimy.; Margarita, Gómez.Bello.Rosa.; Marisa, Cñadas.Garre., 2017: Diabetes-related neurological implications and pharmacogenomics. Diabetes mellitus (DM) is the most commonly occurring cause of neuropathy around the world and is beginning to grow in countries where there is a risk of obesity. DM Type II, (T2DM) is a common age-related disease and is a major health concern, pa...

Sery, T.W.; Su, Y-Hsiu.; Eagle, R.; Ueda, M.; Yamamoto, N., 2006: A new procedure for experimental autoimmune uveitis with small uveitogenic peptides. Demonstration of experimental autoimmune uveitis (EAU) with extremely small, fragmented peptides (12-30 amino acid residues) of interphotoreceptor retinoid-binding protein (IRPB). Very small fragmented peptides (no. 854, 888, 907, and 1057) were c...

Anonymous, 1994: American Society of Andrology. 19th Annual meeting. Springfield, Illinois, March 3-7, 1994. Abstracts. Journal of Andrology Suppl: 10-57