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Considerations for clinical trial design and data analyses of thorough QT studies using drug-drug interaction

, : Considerations for clinical trial design and data analyses of thorough QT studies using drug-drug interaction. Journal of Clinical Pharmacology 50(10): 1106-1111


PMID: 20457587

DOI: 10.1177/0091270009358710

Other references

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Griffith, M.J.; Kingdon, H.S.; Lundblad, R.L., 1979: Inhibition of the heparin-antithrombin III/thrombin reaction by active site blocked-thrombin. Biochemical and Biophysical Research Communications 87(3): 686-692

Guillet, M.; Boiteux, S., 2002: Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae. In Saccharomyces cerevisiae, mutations in APN1, APN2 and either RAD1 or RAD10 genes are synthetic lethal. In fact, apn1 apn2 rad1 triple mutants can form microcolonies of approximately 300 cells. Expression of Nfo, the bacterial homologue of Apn1,...

Ooyama, N., 1958: The effects of leaf sprays of urea on rooting of Cryptomeria japonica cuttings. Studies on races difficult to root in the Kitayama district of Kyoto.. Summarizes experiments with cuttings from trees of various races and ages, using different rooting techniques and soils. Planting cuttings with their ends covered by a ball of red earth was beneficial in soils where rotting or drying out were grea...

Taherzade, D.; Soleimannejad, J., 2016: Application of ultrasound to the synthesis of a new nanostructured Mn(II) supramolecular compound: A precursor for γ-Mn2O3 nanoparticles. A new nanostructured Mn(II) supramolecular compound [Mn(hpydcH2)2(H2O)4] (1) (hpydcH3=4-hydroxy-2,6-pyridinedicarboxylic acid) has been synthesized using a sonochemical process. The structure of compound 1 was determined by single crystal X-ray di...

Makadia, J.; Bhanot, N.; Mancini, S.A.; Min, Z., 2014: Clinical evolution, management, and resolution of type II necrotizing fasciitis. Internal and Emergency Medicine 10(3): 389-391

Abu Samra, M.T., 1999: The efficacy of sebacil E.C.50%, Gamatox and Ivomec in the treatment of sarcoptic mange in camel (Camelus dromedarius). Sixty male camels with well established sarcoptic mange were divided into 6 groups of 10. Each group was respectively treated with Sebacil E.C.50% (diethyl phosphorothioate) with or without pretreatment with salicylic acid, Gamatox (gamma isomer o...

Chang, C.C.; Lin, B.Y.; Hu, S.P., 1975: Observations on some simple peptides and two unknown Pauly-positive components in normal plants, crown-gall tumors and tomato nematode gall. Using a combination procedure of SP-Sephadex column chromatography and paper chromatography on 5 different plants, peptide fractions in normal stems, crown-gall (Agrobacterium tumefaciens) tumours and galls of Meloidogyne incognita were compared....

Liu Bin; Jin DaDi; Q.D.ngBin et al., 2007: Role and change of IL-1 beta , IL-6 and TNF- alpha during rabbit lumbar cartilage endplate degeneration. A study was conducted to study the role of nitric oxide on the degeneration of the cartilage end-plate (CEP). 24 New Zealand rabbits were divided into experimental and control groups. In the experiment group, the model of lumbar CEP degeneration w...

Yamanaka, S.N.mai,, T.S.saki, N.T.kahashi, N., 1980: Antifungal activities of momila. Nihon Shokubutsu Byori Gakkaiho = Annals of the Phytopathological Society of Japan 46(4): 494-498