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Correlation between expression and differentiation of endocan in colorectal cancer


, : Correlation between expression and differentiation of endocan in colorectal cancer. World Journal of Gastroenterology 14(28): 4562-4568

To investigate the expression frequency of endocan in colorectal cancer and analyze the relationship between endocan expression and clinical parameters and to study the role of endocan in colorectal carcinogenesis. Expression of endocan in 72 tumor tissue samples of colorectal cancer as well as in 27 normal mucous membrane tissue samples was analyzed using in situ hybridization, immunohistochemistry on tissue microarray, Western blot and reverse-transcript polymerase chain reaction (RT-PCR). The expression of endocan was higher in normal colon and rectum tissue samples than in cancerous tissue samples (mRNA = 92.6%, protein = 36%), and was lower in colorectal cancer tissue samples (mRNA = 70.4%, protein = 36.1%). No correlation was found between staining intensity and clinical parameters such as sex, age, tumor size and TNM stage. However, the expression of endocan was positively correlated with the tissue differentiation in colorectal cancer. The expression of endocan is down-regulated in colorectal cancer and is positively correlated with the tissue differentiation in colorectal cancer, suggesting that the expression of endocan is associated with development and differentiation of colorectal cancer.

US$29.90

PMID: 18680240


Other references

Stober, R., 1990: Microsurgical flap-plasty. Aktuelle Probleme in Chirurgie und Orthopadie 34: 142-147

Goligher, J.C., 1983: The use of pedicled transplants of sigmoid or other parts of the intestinal tract for vaginal construction. The use of transplants from different parts of the intestinal tract for vaginal construction is surveyed and the special value of sigmoid colon for this purpose is demonstrated by the results obtained in 7 patients treated by the author.

Heiss, E., 1990: A review of the genus Dysodius Lepeletier Serville, 1828, with descriptions of two new species Heteroptera; Aradidae. Anales del Instituto de Biologia Universidad Nacional Autonoma de Mexico Serie Zoologia, 612: 279-295

Venda, L.Lourenço.; Cragg, S.J.; Buchman, V.L.; Wade-Martins, R., 2011: α-Synuclein and dopamine at the crossroads of Parkinson's disease. α-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinal motor symptoms are linked to death of dop...

Saltzmann, R.M.; Lissner, G.S., 2006: Familial absence of lacrimal puncta associated with preauricular sinuses. Previously reported cases of lacrimal outflow dysgenesis have frequently been associated with developmental anomalies or systemic syndromes, raising potential red flags in affected children. We report an unusual case of familial punctal atresia wi...

Criddle, R.S.; Packer, L.; Shieh, P., 1977: Oligomycin dependent ionophoric protein subunit of mitochondrial atpase ec 3.6.1.3. A proteolipid isolated from yeast [Saccharomyces cerevisiae] mitochondrial adenosinetriphosphatase (subunit 9) (ATP phosphohydrolase; EC 3.6.1.3) by chloroform/methanol extraction was shown to discharge photo-induced potentials across a planar pho...

Lopez-Martinez, V.; Romero-Napoles, J.; Gonzalez-Hernandez, A.; Equihua-Martinez, A.; Ramirez-Alarcon, S.; Sanchez-Garcia, J., A., 2003: Descripcion del macho de Triaspis kurtogaster Martin y comentarios en la distribucion de T. azteca Martin y T. eugenii Wharton y Lopez-Martinez (Hymenoptera: Braconidae). The male of T. kurtogaster Martin is recorded for first time and a description of it is given. New distribution records are given for T. azteca Martin and T. eugenii Wharton & Lopez-Martinez in Mexico. A key for the identification of the Mexican s...

Carlhant D.; Bonissent J.F.; Guedes Y.; L.G.rrec J.; Rakotoseheno J.C.; Colin J.; Riche C., 1987: Comparison between penetration of cefotaxime and cefoperazone in the vitreous. Twenty three patients of ophthalmology surgery have received two cephalosporins (cefotaxime and cefoperazone) with the same dosage regimen: a loading dose of 1 g and an infusion of 4 g during 8 hours. The antibiotic concentrations were determined...

Holtzer, M.E.; Holtzer, A., 1992: Alpha-helix to random coil transitions: determination of peptide concentration from the CD at the isodichroic point. A method is presented for determining the concentrations of peptides and proteins having isodichroic points near 203 nm. The existence of an isodichroic point for a given substance indicates a local two-state (alpha-helix, random coil) population....

Zhutaev, I.A., 1969: Method of impregnation of sections glued onto glass. Arkhiv Patologii 31(6): 82-83