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Correlation of microsatellite instability at multiple loci with long-term survival in advanced gastric carcinoma


, : Correlation of microsatellite instability at multiple loci with long-term survival in advanced gastric carcinoma. Archives of Surgery 144(8): 722-727

Microsatellite instability (MSI) correlates with clinicopathologic characteristics and long-term prognosis in patients having gastric carcinoma. Analysis of prospectively collected data and biologic material. Tertiary University Hospital, Policlinico "Le Scotte," Siena, Italy. Two hundred fifty patients with gastric carcinoma. Five mononucleotide repeats (BAT-26, BAT-25, NR-24, NR-21, and NR-27) were analyzed in these patients. An MSI phenotype was identified in 63 patients (25.2%) and correlated with specific clinicopathologic characteristics. Favorable prognosis was confirmed for patients with an MSI phenotype in univariate (P < .001) and multivariate (P = .05) analyses. Significant differences in clinicopathologic characteristics and long-term prognoses were observed among patients with microsatellite-stable tumors, tumors having instability at 2 to 4 markers, and tumors having instability at all 5 markers (MSI/5). The MSI/5 phenotype was associated with older age (P < .001), female sex (P = .001), antral tumor location (P = .04), intestinal histotype (P = .003), and less infiltration of the serosa (P = .006); lymph node involvement was rare (P < .001) and was limited to few (median, 3) metastatic lymph nodes (P = .001). Long-term survival of patients with the MSI/5 phenotype is favorable and was confirmed in multivariate analysis (relative risk vs patients with stable tumors, 0.32; 95% confidence interval, 0.16-0.63; P = .002). Compared with stable tumors, MSI tumors have distinct clinicopathologic features and are associated with a better prognosis. Patients with the MSI/5 phenotype have a very good prognosis.

US$19.90

PMID: 19687375

DOI: 10.1001/archsurg.2009.42


Other references

Borello France, D.F.; Whitney, S.L.; Herdman, S.J., 1994: Assessment of vestibular hypofunction. Herdman, S J [Author] Contemporary Perspectives in Rehabilitation; Vestibular rehabilitation 247-286

Llorca, F.Orts., 1964: What are the factors which lead to the fusion of the two heart primordia ? An experimental analysis. 1. In stages 5 and 6 ofHAMBURGER andHAMILTON, the presumptive heart primordia of both sides, placed in contact, Fig. 1, originate two hearts in many cases instead of joining and originating a unique heart, as happens during normogenesis. 2. The tw...

Babel, J.; Psilas, K., 1973: Carotid stenoses and thromboses. Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift für Augenheilkunde 167(4): 273-287

Tomczak M.Jr, 1981: A multi parameter extension of temperature salinity diagram techniques for the analysis of nonisopycnic mixing. The technique of water mass analysis based on temperature-salinity curves is extended to > 3 water masses (or water masses defined by temperature-salinity curves rather than points) by including .gtoreq. 1 additional parameters and solving the...

Naso, O., 1951: Indications and technic of skin grafting in the oral cavity. Nova Acta Stomatologica 3(1): 11-18

Haynes, R.; Harden, P.; Judge, P.; Blackwell, L.; Emberson, J.; Landray, M.J.; Baigent, C.; Friend, P.J.; Friend, P.J.; Haynes, R.; Baigent, C.; Harden, P.; Landray, M.J.; Akyol, M.; Asderakis, A.; Baxter, A.; Bhandari, S.; Chowdhury, P.; Clancy, M.; Gibbs, P.; Hammad, A.; Herrington, W.; Jayne, K.; Jones, G.; Krishnan, N.; Lay, M.; Lewis, D.; Macdougall, I.C.; Nathan, V.Chidambaram.; Neuberger, J.; Newstead, C.; Pararajasingam, R.; Puliatti, C.; Rigg, K.; Rowe, P.; Sharif, A.; Sheerin, N.; Sinh, 2015: Alemtuzumab-based induction treatment versus basiliximab-based induction treatment in kidney transplantation (the 3C Study): a randomised trial. Calcineurin inhibitors (CNIs) reduce short-term kidney transplant failure, but might contribute to transplant failure in the long-term. The role of alemtuzumab (a potent lymphocyte-depleting antibody) as an induction treatment followed by an early...

Miller James D.Jr., 1983: Major element chemistry of anorthosites from the Duluth Complex Snowbank Lake Quadrangle, Minnesota. Proceedings and Abstracts - Institute on Lake Superior Geology, Annual Meeting 29: 28-29

D.M.rchi, S.; Cecchin, E.; Basile, A.; Proto, G.; Donadon, W.; Jengo, A.; Schinella, D.; Jus, A.; Villalta, D.; D.P.oli, P., 1984: Close genetic linkage between HLA and renal glycosuria. Renal glycosuria is an inherited disorder of renal tubule function in which significant amounts of glucose are excreted in the urine in the simultaneous presence of normal blood glucose levels. Renal glucose titration analyses and HLA genotypes we...

Mural, R.J.; Friedman, D.I., 1974: Isolation and characterization of a temperate bacteriophage specific for Rhodopseudomonas spheroides. The isolation of a temperature phage specific for the photosynthetic bacterium Rhodopseudomonas spheroides is reported. This phage, Rphi-1, establishes a state of lysogeny and can be induced from the prophage state by exposure to mitomycin C or UV...

Huang HaoJen; Chen Yu; Kuo JungLieh; Kuo TsongTeh; Tzeng ChaiChong; Huang BauLian; Chen ChungMong; Huang LiChun, 1996: Rejuvenation of Sequoia sempervirens in vitro: changes in isoesterases and isoperoxidases. Rejuvenation, as evidenced by restored rooting competence, of Sequoia sempervirens by a series of repeated grafting of adult shoot tips onto juvenile rootstocks in vitro was confirmed. Complete restoration of rooting competence was achieved after...