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Crosstalk between the circadian clock circuitry and the immune system

, : Crosstalk between the circadian clock circuitry and the immune system. Chronobiology International 30(7): 870-888

Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle. Moreover, different immune cell types, such as macrophages, natural killer cells, and lymphocytes, contain a circadian molecular clockwork. The biological clocks intrinsic to immune cells and lymphoid organs, together with inputs from the central pacemaker of the suprachiasmatic nuclei via humoral and neural pathways, regulate the function of cells of the immune system, including their response to signals and their effector functions. Consequences of this include, for example, the daily variation in the response to an immune challenge (e.g., bacterial endotoxin injection) and the circadian control of allergic reactions. The circadian-immune connection is bidirectional, because in addition to this circadian control of immune functions, immune challenges and immune mediators (e.g., cytokines) were shown to have strong effects on circadian rhythms at the molecular, cellular, and behavioral levels. This tight crosstalk between the circadian and immune systems has wide-ranging implications for disease, as shown by the higher incidence of cancer and the exacerbation of autoimmune symptoms upon circadian disruption.


PMID: 23697902

DOI: 10.3109/07420528.2013.782315

Other references

Caballero, Y.C.E.; Caballero, R.G., 1969: Trematodos de las tortugas de Mexico, 11, Acanthostomum nuevoleonensis n. sp. Parasito de Trionyx spinifer emoryi (Agassiz, 1857). Anales de la Escuela Nacional de Ciencias Biologicas Mexico, 131964: 83-90

Razvi, S.; Weaver, J.U.; Vanderpump, M.P.; Pearce, S.H.S., 2010: The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort. The Whickham Survey evaluated vascular events over 20 yr in community-dwelling subjects stratified by thyroid function and thyroid autoantibody status. No association between ischemic heart disease (IHD) and a composite autoimmune thyroid disease...

Van Harten A., 1979: Sitobion hillerislambersi new species a remarkable new aphid from angola homoptera aphidoidea. S. hillerislambersi sp. nov., living on the undersides of leaves of Cyperus esculentus L., is described from central Angola. Differences between the new species and the nearest relatives [S. pauliani, S. anselliae and S. ochnearum] are discussed.

Yoda, S.; Yoda, A., 1986: ADP- and K+-sensitive phosphorylated intermediate of Na, K-ATPase. In the phosphoenzyme (EP) of the electric eel Na,K-ATPase, the sum of the ADP-sensitive EP and the K+-sensitive EP exceeds 150% of EP in the presence of 100 mM Na+. This unusual phenomenon can be explained by the formation of three phosphoenzymes:...

Hladik, J., 1937: Determination of crude fibre in oil-containing seeds and in pressed cake obtained from them. The fat is extracted from 1 g. of the material with CCl4. The dried residue is transferred to a flask and boiled for 1/2 hour under a reflux with 3-4 ml. HNO3 and 30 ml. glacial acetic acid. The contents of the flask are then transferred to a 500...

Blumenthal, A.; Cerny, M.; Helbling, J., 1978: Determination of the fat free dry mass of cocoa in foods containing malt. The application of high pressure liquid chromatography for the determination of fat free dry matter of cacao in malt containing products is described. The method is based on the determination of the alkaloid content. The water soluble fractions of...

Mack, R.N.; Rutter, N.W.; Valastro, S.; Bryant, V.M.J., 1978: Late quaternary vegetation history at waits lake colville river valley washington usa. A 10.6 m section of mostly calcareous sediments at Waits Lake, Washington [USA] reveals a multizoned history of vegetation change since recession of Pinedale (P-2) glacial ice from the Colville River Valley. The oldest unit with high percentages o...

Vezzoli, G.C.; Dachille, F.; Roy, R., 1969: Sulfur Melting and Polymorphism under Pressure: Outlines of Fields for 12 Crystalline Phases. The polymorphism of sulfur has been investigated by static and dynamic methods up to 500 degrees C at 35 kilobars and up to 350 degrees C at 100 kilobars. The melting curve of sulfur to 31 kilobars and phase boundaries of the so-called "4.04-...

Remane, A., 1958: Okologie des Brackwassers. Binnengewasser, 22: 1-216

Alonzo, S.; Heyde, M.; Laloi, P.; Portalier, R., 1999: Analysis of the effect exerted by extracellular pH on the maltose regulon in Escherichia coli K-12. The Escherichia coli maltose regulon consists of five operons under the control of the MalT transcriptional activator. lac operon fusions were constructed in vitro with the MalT-dependent promoter and with the malT promoter itself. beta-Galactosid...